Toll-like receptor 5 gene polymorphism is associated with breast cancer susceptibility

Chen, Shuang; Yuan, Weiguang; Fu, Zhenkun; Huang, Yike; Yang, Jiankun; Jing, Xue; Liu, Xinghan; Li, Yue; Li, Dalin

doi:10.18632/oncotarget.20242

Cited by 22 publications

(15 citation statements)

References 22 publications

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“…cai et al (17) further reported that 80% of 75 cases of breast cancer expressed Tlr5, the majority of which were high-grade ductal carcinomas. Tlr5 was also overexpressed in 256 breast carcinomas specimens, and was correlated with lymph node metastasis and cancer grade (18). Furthermore, Berger et al (19) studied frozen breast specimens from 124 female patients with breast cancer and found that Tlr9 mrna expression was positively correlated with tumor grade, suggesting that Tlr9 may be a molecular marker for poorly differentiated breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Expression profile of Toll‑like receptors in human breast cancer

Shi

Fang

et al. 2019

Mol Med Report

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Toll-like receptors (Tlrs) are the most widely studied pattern recognition receptors. Mounting evidence suggests an important association between Tlrs and the occurrence and development of breast cancer. Thus, targeting these receptors may be a potential strategy for breast cancer treatment. The current study analyzed the data of 1,215 patients with breast cancer obtained from The cancer Genome atlas (TcGa) database. it was observed that, in addition to Tlr6, Tlr7 and Tlr8, the expression of the remaining Tlrs in breast cancer tissues was lower than that in normal tissues. in addition, Tlr3 and TLR9 displayed significantly different expression levels in er-/Pr-negative breast cancer compared with the control tissues, while TLR5 expression was significantly reduced in Her2-enriched breast cancer. Furthermore, Tlr10 exhibited lower expression levels in advanced stages of the disease as compared with that observed in earlier stages. Survival analysis revealed that the expression of Tlr4 and Tlr7 had a significant impact on survival, and higher expression levels suggested worse prognosis. Finally, the expression levels of Tlr1, Tlr2, Tlr4, Tlr5, Tlr6 and Tlr10 were correlated with those of the inflammatory cytokines interleukin-1β and tumor necrosis factor-α, while the expression levels of Tlr3, Tlr7, Tlr8 and Tlr9 were correlated with those of interferon-β and c-X-c motif chemokine ligand 10. Taken together, the current study results suggest that Tlr expression may serve as a biomarker of cancer pathogenesis and progression, and may provide new insights for the treatment of breast cancer through the regulation and targeting of Tlrs.

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Section: Introductionmentioning

confidence: 99%

Expression profile of Toll‑like receptors in human breast cancer

Shi

Fang

et al. 2019

Mol Med Report

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“…They found that rs5744168 T allele encodes a stop at codon 392, affecting TLR5 signaling, and it is associated with sporadic breast cancer occurrence (OR > 1). On the other hand, they found no association between rs2072493 G allele and breast cancer risk [67]. Klimosch et al found that rs2072493 (A > G), nonsynonymous SNP coding for N592S is associated with colorectal cancer-specific and overall survival.…”

Section: • Potential Association Between Tlr4 Polymorphisms and Cancementioning

confidence: 99%

Toll-Like Receptors Gene Polymorphism and Susceptibility to Cancer Development

Semlali¹,

Alnemari²,

Almalki³

et al. 2018

Genetic Diversity and Disease Susceptibility

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Toll-like receptors (TLRs) play an important role in immune-surveillance and responses towards pathogenic and non-pathogenic microorganisms. They act as innate immune sensors against endogenous and exogenous danger signals by recognizing the pattern recognition molecules (DAMPs and PAMPs) and drive an adaptive immune response through their signaling pathways, which leads to NF-κB and IRF3 transactivation and induces different inflammatory cytokine genes. TLRs polymorphisms were investigated in various cancer types studies. However, precious studies have reported that the Polymorphisms on TLR1-TLR10 cluster have been associated with increased risk of prostate cancer. However, it has known that TLRs genetic variation is associated with increased the susceptibility to gastric cancer. A same synthetically meta-analysis also confirmed the association of TLRs with increased the gastrointestinal cancer but with decreased prostate cancer risk. Our previous studies have demonstrated a strong link between TLRs polymorphisms and colon cancer and breast cancer in Saudi Arabia population. Similar studies were analyzed with Korean patients with papillary thyroid cancer and their clinic-pathologic features in age matched controls by using direct sequencing. The general objective of this chapter was to investigate the role of different TLRs (i.e., TLR2, TLR4, and TLR6) polymorphisms and their association with cancer development.

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“… 5 According to a previous study, tumor biomarkers are associated with the tumorigenesis and progression of various cancers, such as breast cancer. 6 Therefore, there is a need to explore additional and convincing treatment drugs or tumor biomarkers to improve the efficacy of therapy in OTSCC patients.…”

Section: Introductionmentioning

confidence: 99%