2018
DOI: 10.1080/2162402x.2018.1505174
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Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells

Abstract: In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy. However, the mechanism of this effect has been elusive. Here, using a murine model of lung adenocarcinoma, we demonstrate a key role for TLR7 expressed by malignant (rather than by stromal and immune) cells, in the recruitment of myeloid derived suppressor cells (MDSCs), induced after TLR7 stimulation, resulting in ac… Show more

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Cited by 38 publications
(38 citation statements)
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“…TLR7 stimulation had a prometastatic effect, while MDSC depletion drastically reduced the number of metastases. In line with the involvement of epithelial-mesenchymal transition (EMT) in the metastatic process, lung tumors expressing high levels of TLR7 have high expression of vimentin and low abundance of E-cadherin [96].…”
Section: Mdscs In Murine Models Of Lcmentioning
confidence: 93%
“…TLR7 stimulation had a prometastatic effect, while MDSC depletion drastically reduced the number of metastases. In line with the involvement of epithelial-mesenchymal transition (EMT) in the metastatic process, lung tumors expressing high levels of TLR7 have high expression of vimentin and low abundance of E-cadherin [96].…”
Section: Mdscs In Murine Models Of Lcmentioning
confidence: 93%
“…19 Recently, enhanced expression of TLRs has been described in a variety of solid tumors including colon, pancreatic, and breast cancer. 12,13,[20][21][22] A study analyzing TLR3, TLR4, and TLR9 in breast cancer associated TLR expression with the risk for metastases. 20 In addition, our previous studies showed that TLR7 and TLR8 were co-expressed with CD133, a marker for cancer-initiating cells in CRC.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the expression of TLRs on tumor cells has to be taken into consideration when activation might lead to protumoral effects [4,36,37]. For example, TLR7 stimulation in primary lung carcinoma could promote tumor growth through the recruitment of myeloid-derived suppressor cells [32,38,39].…”
Section: Pattern Recognition Receptor Agonistsmentioning
confidence: 99%