“…Takifugu rubripes (Oshiumi et al 2003), Danio rerio (Meijer et al 2004;Nie et al 2018), Paralichthys olivaceus (Hirono et al 2004), Ictalurus punctatus (Baoprasertkul et al 2007;Quiniou et al 2013), Oncorhynchus mykiss (Palti et al 2010;Brietzke et al 2016), Epinephelus coioides (Wei et al 2011), Pseudosciaena crocea (Ao et al 2016), Labeo rohita (Samanta et al 2012), Cirrhinus mrigala (Basu et al 2012), Cyprinus carpio (Fink et al 2016), Ctenopharyngodon idella (He et al 2016) and Catla catla (Patel et al 2019). The activation of MyD88dependent TLR-signaling pathways results in the induction of various downstream signaling molecules such as IRAK, TAB1, TAB2 and TRAF6 (Rebl et al 2008;Patel et al 2019;Li et al 2019) to induce the synthesis of pro-inflammatory cytokines and Type-I-interferons. TLR comprises of extracellular N-terminus with leucine-rich repeat (LRR) region, trans-membrane (TM) domain and intracellular C-terminus with Toll/IL-1 receptor domain (TIR).…”