The unidentified virus that causes tomato flu is an infectious disease.Tomato-shaped ulcers that appear all over the body and develop into tomatoes in appearance are the infection's disease virus, hence the name "Tomato flu" or "Tomato fever.It primarily affects young children under five.. A "Hand, Foot, and Mouth disease" is tomato flu. HFMD is caused by viruses that belongs enterovirus genus. Coxsackie virus A16is most frequent cause of HFMD. Although there is a low chance that this illness will produce meningitis. Tomato flu is originally discovered in Kerala. Tamil Nadu, Orissa, and the rest of India have not yet seen the effects of the virus outside of Kerala.The majority of clinical manifestations cases are minor. The infection is self-limiting and will go away on its own in 7–10 days.In areas where there are outbreaks, On the basis of the physical examination and clinical history, the diagnosis is made. It typically breaks out in epidemics throughout the spring, summer, and winter. The etiological agent of this infectious disease, its course of therapy, and vaccine are still unknown, and this is an important topic of research right now. The most efficient and affordable methods of preventing viral infections in the general population.There are currently non-antiviral drugs and vaccinations available for the treatment and prevention of tomato flu.COVID-19 has provided valuable lessons for prepare for outbreaks and manage cases under emergency circumstances by repurposing medications and vaccines, which is another way to say that efforts are now being made to control the condition.