Tongue Metastasis as an Initial Presentation of a Lung Cancer

Terashima, Takeshi; Matsuzaki, Tatsu; Kawada, Ichiro; Nishida, Jiro; Tanaka, Yoïchi; Morishita, Testuo; Takeyasu, Yoshihiro; Yamane, Gen Yuki; Uchiyama, Takeshi

doi:10.2169/internalmedicine.43.727

Cited by 20 publications

(16 citation statements)

References 6 publications

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“…However, lingual metastasis usually was found beneath the normal squamous epithelium of the tongue without dysplasia, thus sparing the tongue mucosa. Additionally, numerous tumorlets were found in the lymphatic vessels, which was further evidence of lymphatic metastasis [10,11,12]. In our case, there was no suspicious sign of lingual metastasis in the base of the tongue specimen.…”

Section: Discussionsupporting

confidence: 50%

Metachronous Adenoid Cystic Carcinoma in the Peripheral Lung and at Base of the Tongue

Kim

Ahn

Kim

et al. 2014

Clin Exp Otorhinolaryngol

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Primary lung adenoid cystic carcinoma (ACC) is extremely rare and accounts for approximately 0.1%-0.2% of all lung cancers. ACC of the head and neck has generally been regarded as a slow-growing, low-grade malignancy which has a tendency for local recurrence and frequent distant metastasis. When ACC of the lung is identified, physicians must determine whether it represents distant metastasis or a primary lung cancer. Thyroid transcription factor-1 staining is one of the most useful methods to differentiate primary from metastatic lesions in lung cancer. Herein we report a case of metachronous, not synchronous, ACC at the peripheral lung followed by ACC presentation at the base of the tongue, and review of relevant literatures.

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Section: Discussionsupporting

confidence: 50%

Metachronous Adenoid Cystic Carcinoma in the Peripheral Lung and at Base of the Tongue

Kim

Ahn

Kim

et al. 2014

Clin Exp Otorhinolaryngol

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“…There are reports of tongue metastasis from squamous, large cell lung carcinoma and adenocarcinoma as in our patient 1 12…”

Section: Discussionmentioning

confidence: 53%

Oral and gastrointestinal symptomatic metastases as initial presentation of lung cancer

Jeba

Backianathan²,

Ishitha

et al. 2016

BMJ Case Reports

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Metastasis to the tongue, duodenum or pancreas from primary lung cancer is uncommon. Primary lung cancer presenting with symptoms related to metastases at these sites, at initial presentation is extremely rare. We report a 45-year-old man with disseminated lung malignancy who presented with dyspepsia, melena, symptoms due to anaemia and swelling in the tongue. Oral examination revealed a hard submucosal anterior tongue lesion. Biopsies from the tongue lesion and the duodenal ulcer seen on upper gastrointestinal endoscopy were suggestive of metastasis from lung primary. CT revealed lung primary with disseminated metastasis to lung, liver, adrenals, kidneys, head and body of pancreas, duodenum and intra-abdominal lymph nodes. The patient was treated with palliative chemotherapy. The unusual presentation and diagnostic details are discussed.

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“…Surgical resection can be considered for patients who have isolated lingual metastasis and a resectable primary cancer. Treatment with chemotherapy and irradiation may prove to be effective in the treatment of metastatic disease, [11] but in our case is not effective.…”

Section: Discussionmentioning

confidence: 58%