Tonsil-derived mesenchymal stem cells alleviate concanavalin A-induced acute liver injury

Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy

“…Although we recently reported that TMSC alone greatly improved liver function in model rats with liver damage induced by concanavalin A [31] or CCl 4 [32], our current data clearly show an important role for use of scaffolds such as Matrigel in recovering parathyroid function in PTX rats. Indeed, without Matrigel, TMSC did not improve parathyroid cell function, suggesting that scaffold and/or its communication with TMSC is likely to determine the success of stem cell therapy, at least in our disease model.…”

Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy

“…The International Society for Cellular Therapy has designated this expression pattern as the minimal criteria for human MSC discretion, but marker expression panels for MSCs continue to be updated over time [6,7] . Though MSCs were first isolated from the bone marrow, they have since been harvested from the stroma of multiple organs and tissues, including adipose, tonsils, umbilical cord, skin, and dental pulp [8][9][10][11][12][13] . MSCs derived from the marrow continue to be the most frequently studied.…”

The potential antifibrotic impact of apocynin and alpha-lipoic acid in concanavalin A-induced liver fibrosis in rats: Role of NADPH oxidases 1 and 4

“…T-cell activation elicited by ConA resulted in the elevation of the cytokines TNF-α and IL-6, which play critical roles in the development of ConAinduced hepatic injury (38,39). Furthermore, TNF-α stimulates the release of cytokines and promotes oxidative stress causing liver damage (40).…”