Tonsillectomy and inflammatory bowel disease: a meta‐analysis

Xiong, Hanzhen; Wang, Ben; Zhao, Zihan; Hong, Junbo; Zhu, Yin; Zhou, Xiaojiang; Xie, Yong

doi:10.1111/codi.13323

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…The association between tonsillectomy and IBD has been controversial throughout the different studies published until today. For instance, different meta-analysis have concluded that there is no association between these 2 factors, [44] and even that tonsillectomy is a risk factor for developing CD, [45] contrary to what has been found in this study.…”

Section: Discussioncontrasting

confidence: 98%

Incidence and prevalence of inflammatory bowel disease in Mexico from a nationwide cohort study in a period of 15 years (2000–2017)

et al. 2019

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Section: Discussioncontrasting

confidence: 98%

Incidence and prevalence of inflammatory bowel disease in Mexico from a nationwide cohort study in a period of 15 years (2000–2017)

et al. 2019

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“…Tonsillectomy was linked with CD but not NIC or UC. However, patients undergoing tonsillectomy have often been exposed to previous antibiotics [65].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: A Mendelian Randomization Analysis Investigates Causal Associations between Inflammatory Bowel Diseases and Variable Risk Factors

et al. 2023

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The question of whether variable risk factors and various nutrients are causally related to inflammatory bowel diseases (IBDs) has remained unanswered so far. Thus, this study investigated whether genetically predicted risk factors and nutrients play a function in the occurrence of inflammatory bowel diseases, including ulcerative colitis (UC), non-infective colitis (NIC), and Crohn’s disease (CD), using Mendelian randomization (MR) analysis. Utilizing the data of genome-wide association studies (GWASs) with 37 exposure factors, we ran Mendelian randomization analyses based on up to 458,109 participants. Univariable and multivariable MR analyses were conducted to determine causal risk factors for IBD diseases. Genetic predisposition to smoking and appendectomy as well as vegetable and fruit intake, breastfeeding, n-3 PUFAs, n-6 PUFAs, vitamin D, total cholesterol, whole-body fat mass, and physical activity were related to the risk of UC (p < 0.05). The effect of lifestyle behaviors on UC was attenuated after correcting for appendectomy. Genetically driven smoking, alcohol consumption, appendectomy, tonsillectomy, blood calcium, tea intake, autoimmune diseases, type 2 diabetes, cesarean delivery, vitamin D deficiency, and antibiotic exposure increased the risk of CD (p < 0.05), while vegetable and fruit intake, breastfeeding, physical activity, blood zinc, and n-3 PUFAs decreased the risk of CD (p < 0.05). Appendectomy, antibiotics, physical activity, blood zinc, n-3 PUFAs, and vegetable fruit intake remained significant predictors in multivariable MR (p < 0.05). Besides smoking, breastfeeding, alcoholic drinks, vegetable and fruit intake, vitamin D, appendectomy, and n-3 PUFAs were associated with NIC (p < 0.05). Smoking, alcoholic drinks, vegetable and fruit intake, vitamin D, appendectomy, and n-3 PUFAs remained significant predictors in multivariable MR (p < 0.05). Our results provide new and comprehensive evidence demonstrating that there are approving causal effects of various risk factors on IBDs. These findings also supply some suggestions for the treatment and prevention of these diseases.

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“…Tonsillectomy was associated with subsequent CD (OR, 1.37; 95% CI, 1.16-1.62) but not UC or IBD ( Figure 2 and Supplementary Tables 1-3). 35,36 However, antibiotic exposure may be an unmeasured confounder (individuals having tonsillectomy have often experienced previous exposure to antibiotics).…”

Section: Surgeriesmentioning

confidence: 99%

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

et al. 2019

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Our study protocol was registered with PROSPERO (registration number: CRD42018112214). We followed a standardized methodology 7 and report findings according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (ie, PRISMA) 8 and Meta-analyses of Observational Studies in Epidemiology (ie, MOOSE) 9 recommendations. Search Strategy We systematically searched PubMed, Embase, and Scopus from inception through September 28, 2018, to identify metaanalyses of studies assessing the association between environmental factors and IBD. Search terms included inflammatory bowel disease, Crohn's disease, or ulcerative colitis, combined with systematic review or meta-analysis. We excluded conference abstracts, letters, editorials, and articles published in languages other than English. The reference lists of the identified meta-analyses were screened for additional eligible articles. No other restrictions were imposed.

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Tonsillectomy and inflammatory bowel disease: a meta‐analysis

Abstract: No obvious association between tonsillectomy and inflammatory bowel disease was identified in our meta-analysis.

Cited by 9 publications

References 45 publications

Incidence and prevalence of inflammatory bowel disease in Mexico from a nationwide cohort study in a period of 15 years (2000–2017)

Incidence and prevalence of inflammatory bowel disease in Mexico from a nationwide cohort study in a period of 15 years (2000–2017)

RETRACTED: A Mendelian Randomization Analysis Investigates Causal Associations between Inflammatory Bowel Diseases and Variable Risk Factors

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

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