2019
DOI: 10.1016/j.toxlet.2019.01.010
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Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes – A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae

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Cited by 43 publications
(76 citation statements)
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“…Following the study of Richter et al (2019a), zebrafish maintenance and all experiments with larvae were performed according to internal protocols based on standard methods (Westerfield 2007). Zebrafish larvae were raised at 28 °C in Danieau's medium consisting of 17 mM NaCl, 2 mM KCl, 0.12 mM MgSO 4 , 1.8 mM Ca(NO 3 ) 2 , 1.5 mM HEPES, and 1.2 µM methylene blue.…”
Section: Maximum-tolerated Concentration (Mtc) Studies In Zebrafish Lmentioning
confidence: 99%
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“…Following the study of Richter et al (2019a), zebrafish maintenance and all experiments with larvae were performed according to internal protocols based on standard methods (Westerfield 2007). Zebrafish larvae were raised at 28 °C in Danieau's medium consisting of 17 mM NaCl, 2 mM KCl, 0.12 mM MgSO 4 , 1.8 mM Ca(NO 3 ) 2 , 1.5 mM HEPES, and 1.2 µM methylene blue.…”
Section: Maximum-tolerated Concentration (Mtc) Studies In Zebrafish Lmentioning
confidence: 99%
“…In compliance with an already described procedure (Richter et al 2019a), 4F-Cy-BAP or Fu-BAP were administered to the zebrafish larvae (4 dpf) via medium. One well of a 6-well plate contained 10 zebrafish larvae and 2 mL of Danieau's medium spiked with the compound (100 µM 4F-Cy-BAP or 80 µM Fu-BAP final concentrations, respectively).…”
Section: In Vivo Identification Of Metabolitesmentioning
confidence: 99%
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“…The zebra sh has been widely used in developmental biology, toxicology, genetics, and pharmacology because the sh is small, easy to cultivate and manage, and has a short reproductive cycle; in vitro fertilization and development are possible; and the embryos are easily observed and treated. 33,34 The components of PM2.5 are complex and enter the cardiovascular system through the lung-capillary barrier. Currently, the toxicity screening research and application of drugs resulting from this research primarily focus on neurotoxicity, cardiotoxicity, embryonic developmental toxicity, and so on.…”
Section: Discussionmentioning
confidence: 99%
“…Incubations using HepaRG cells were performed according to a previous publication (Richter et al 2019). For each experiment, cells were maintained in an incubator (Binder, Tuttlingen, Germany) at 37 °C with 95% air humidity and 5% CO 2 atmosphere.…”
Section: Incubations Using Heparg Cellsmentioning
confidence: 99%