Toona sinensis (aqueous leaf extracts) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cells

Chen, Yung Chia; Chien, Ling Hui; Huang, Bu Miin; Chia, Yi Chen

doi:10.1016/j.jff.2014.01.024

Cited by 13 publications

(10 citation statements)

References 34 publications

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“… 34 Chen et al found TSL-1 (0.375 and 0.5 mg/mL) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cell lines (786-O and A-498). 35 The dose was somewhat higher than ours, and the mechanism was also different. The antitumor effect of TS is not a specific finding of our group.…”

Section: Discussioncontrasting

confidence: 54%

The Fractionated Toona sinensis Leaf Extract Induces Apoptosis of Human Osteosarcoma Cells and Inhibits Tumor Growth in a Murine Xenograft Model

Tai

et al. 2016

Integr Cancer Ther

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Background: Osteosarcoma is a malignant bone tumor prevalent in adolescents with poor prognosis. Toona sinensis showed potent antiproliferation effect on lung, melatonin, ovary, colon, and liver cancers. However, the effects of the species on osteosarcoma cells are rarely investigated. Results: In this study, we found fraction 1 of Toona sinensis leaf (TSL-1) resulted in inhibition of cell viability in MG-63, Saos-2, and U2OS osteosarcoma cell lines, while it only caused a moderate suppressive effect on normal osteoblasts. In addition, TSL-1 significantly elevated lactate dehydrogenase leakage and induced apoptosis and necrosis in Saos-2 cells. TSL-1 increased mRNA expression of pro-apoptotic factor Bad. Most important, TSL-1 significantly suppressed Saos-2 xenograft tumor growth in nude mice by increasing caspase-3. The IC-50 of TSL-1 for the 3 tested osteosarcoma cells is around 1/9 of that for lung cancer cells. Conclusion: We demonstrated that TSL-1, a fractionated extract from TSL, caused significant cytotoxicity to osteosarcoma cells due to apoptosis. In vivo xenograft study showed that TSL-1 suppressed the growth of osteosarcoma cells at least in part by inducing apoptosis. Our results indicate that TSL-1 has potential to be a promising anti-osteosarcoma adjuvant functional plant extract.

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Section: Discussioncontrasting

confidence: 54%

The Fractionated Toona sinensis Leaf Extract Induces Apoptosis of Human Osteosarcoma Cells and Inhibits Tumor Growth in a Murine Xenograft Model

Tai

et al. 2016

Integr Cancer Ther

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“…ROSs play an important role in the mediation of apoptosis by inducing the activation of caspases. Among all of the caspase members, caspase-3 in particular is an essential apoptotic effector that leads to cytoskeletal breakdown, nuclear, and other cell changes associated with apoptosis (Bratton & Cohen, 2001;Chen, Chien, Huang, & Chia, 2014). Mechanisms that activate caspase-8 and caspase-9 or executioner caspase-3 are known to be involved in cisplatin-induced tubular cell apoptosis, and caspase inhibition markedly reduces kidney injury (Jo, Cho, Sung, Kim, & Won, 2005).…”

Section: Resultsmentioning

confidence: 99%

Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

Yamabe

Park

Lee

et al. 2015

Journal of Functional Foods

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A B S T R A C TThe protective effects of an extract from bitter melon (Momordica charantia, Cucurbitaceae) against oxidative stress was previously reported and found that protocatechuic acid (PCA) was one of the major phenolic constituents in the extract. The renoprotective effect of PCA from bitter melon was investigated in the present study. In the LLC-PK1 cellular model, the decline in cells viabilities induced by oxidative stress, such as that induced by sodium nitroprusside, pyrogallol, and SIN-1, was significantly and dose-dependently inhibited by PCA.In the in vivo model, the cisplatin-treated rats showed increased plasma levels of creatinine, decreased creatinine clearance, and increased urine protein levels. However, these parameters related to renal dysfunction were markedly attenuated by PCA treatment. Administration of PCA resulted in remarkable improvement in the histological appearance and reduction in tubular cell damage in the cisplatin-treated rat kidneys. Moreover, the elevated levels of pro-caspase-3 induced by cisplatin in rat kidneys were down-regulated by PCA co-treatment. These results suggest that PCA has protective activity against anticancer drug-induced oxidative nephrotoxicity.

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“…For instance, most recently ellagic acid was shown to inhibit aldose reductase which may be associated with the implications for prevention of diabetic complications (Akileshwari et al, 2014). Recent study of the anti-tumour effect of Toona sinensis leaf extract on two clear cell types of renal cell carcinoma cell lines was associated with the presence of quercetin, gallic and tannic acids (Chen, Chien, Huang, & Chia, 2014). Gallic acid, catechaldehyde, syringaldehyde, and catechol were most active in inhibiting the growth of the cancer cell lines at concentrations ranging from 42 to 67 µM (Gonzalez-Sarrias, Li, & Seeram, 2012).…”

Section: Identification and Quantitative Analysis Of Flavonoids And Pmentioning

confidence: 99%

Phytochemical composition and antioxidant properties of Filipendula vulgaris as a source of healthy functional ingredients

Pukalskienė

Venskutonis

Pukalskas

2015

Journal of Functional Foods

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Toona sinensis (aqueous leaf extracts) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cells

Cited by 13 publications

References 34 publications

The Fractionated Toona sinensis Leaf Extract Induces Apoptosis of Human Osteosarcoma Cells and Inhibits Tumor Growth in a Murine Xenograft Model

The Fractionated Toona sinensis Leaf Extract Induces Apoptosis of Human Osteosarcoma Cells and Inhibits Tumor Growth in a Murine Xenograft Model

Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

Phytochemical composition and antioxidant properties of Filipendula vulgaris as a source of healthy functional ingredients

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