Tooth-derived stem cells integrated biomaterials for bone and dental tissue engineering

Vimalraj, Selvaraj; Saravanan, Sekaran

doi:10.1007/s00441-023-03815-0

Cited by 6 publications

(3 citation statements)

References 59 publications

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“…Enriching scaffolds with biomolecules like bone morphogenetic proteins (BMPs) is a recognized approach to enhance bone regeneration [77]. Growth factors, including BMPs, have the potential to significantly improve the effectiveness and speed of bone regeneration and repair in tissue engineering applications related to bones [82].…”

Section: Discussionmentioning

confidence: 99%

“…Differentiation of bone cells can be guided and facilitated in several ways, including the direct transplantation of stem cells to the site of a bone defect, where they can respond to signals from the local microenvironment. Biomaterials can deliver signals that promote bone regeneration, such as calcium phosphate-based materials and controlled-release osteogenic growth factors, integrated into osteogenic scaffolds [81,82].…”

Section: Growth Factors and Bioactive Moleculesmentioning

confidence: 99%

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Biofabrication Approaches for Peri-Implantitis Tissue Regeneration: A Focus on Bioprinting Methods

Shopova,

Mihaylova,

Yaneva

et al. 2024

Prosthesis

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Dental implant utilization has emerged as a contemporary strategy for rectifying dental arch anomalies. However, the effective management of potential complications is paramount. Peri-implantitis, characterized by inflammation and bone resorption around dental implants, resembles periodontitis but specifically affects implant sites. Restoring lost peri-implant tissues poses a multifaceted challenge, with bioprinting methods showing promise as a viable solution. Three-dimensional bioprinting represents a forefront advancement in tissue engineering, traditionally focusing on scaffolds, cells, and signaling pathways. This systematic review aims to aggregate and synthesize data concerning bioprinting’s application in peri-implantitis treatment. Adhering to PRISMA guidelines, the review conducted an extensive literature search across PubMed, Scopus, Google Scholar, and ScienceDirect. Importantly, the search timeframe was not limited, reflecting the scarcity of available information on the subject. Bioprinting advancements offer auspicious avenues for refining treatment modalities, prompting clinicians to explore optimal solutions for establishing ideal anatomical conditions. In essence, this systematic review underscores 3D bioprinting’s potential in peri-implantitis management, highlighting its pivotal role in contemporary dental medicine and its capacity to reshape clinical approaches toward achieving optimal outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Growth Factors and Bioactive Moleculesmentioning

confidence: 99%

Biofabrication Approaches for Peri-Implantitis Tissue Regeneration: A Focus on Bioprinting Methods

Shopova,

Mihaylova,

Yaneva

et al. 2024

Prosthesis

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show abstract

“…Biomaterials and biomaterial-based scaffolds have emerged as promising tools in regenerative endodontic procedures and have made significant strides as part of the biological triad of tissue engineering [ 2 ]. These biomaterials can be utilized for essential pulp treatments, temporary intracanal medications, definitive fillings, apical procedures, and regenerative techniques, enhancing dental treatment approaches across various domains.…”

Section: Introductionmentioning

confidence: 99%

Zinc and Silver-Infused Calcium Silicate Cement: Unveiling Physicochemical Properties and In Vitro Biocompatibility

Singh,

Shivalingam,

Blessy

et al. 2023

Cureus

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Introduction: Calcium silicate-based types of cement have gained recognition in various dental applications due to their exceptional sealing capabilities, bioactivity, and minimal adaptability. However, these materials have certain shortcomings that can lead to mechanical failures and premature degradation. The inclusion of metal ions into their structure is expected to promote their biological activity. This article focuses on the preparation and characterization of calcium silicate cement to enhance its fundamental material properties, by introducing zinc and silver while retaining its biomaterial characteristics. Aim: This study aims to evaluate the biomedical potential of zinc and silver-impregnated bioactive calcium silicate cement. Materials and methods: The calcium silicate powder was synthesized via the sol-gel method. Tetraethyl orthosilicate, calcium nitrate, silver nitrate, and zinc nitrate were sequentially added to create the bioactive calcium silicate material. The synthesized particles underwent physicochemical characterization using techniques such as scanning electron microscopy, X-ray diffraction, Raman spectroscopy, and biological characterization through in vitro hemocompatibility assays. Results: The study's results revealed the presence of multiple crystalline phases (Ag 6 Si 2 O 7 , Zn 2 SiO 4 , CaCO 3 ) as indicated by X-ray diffraction. Raman spectra displayed vibrations associated with Si-O-Si and Zn-O bonding in the zinc and silver-infused bioactive calcium silicate. Scanning electron microscopy confirmed a mixture of spherical and sheet-like morphologies, while energy dispersive spectra confirmed the presence of elements Ca, Si, Zn, Ag, O, and C. In vitro hemocompatibility testing affirmed the material's biocompatible nature. Conclusion: In conclusion, the zinc and silver-infused calcium silicate cement was successfully synthesized through an in-house procedure and demonstrated biocompatibility. The inclusion of zinc and silver, known for their osteogenic and antimicrobial properties, is anticipated to enhance the cement's biological properties and broaden its utility in dentistry. Further in vitro and in vivo investigations are imperative to validate its clinical applications and elucidate the molecular mechanisms underlying its efficacy.

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Dental Pulp-Derived Mesenchymal Stromal Cells

Yildirim

2024

Dental Pulp Derived Mesenchymal Stromal Cells

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Tooth-derived stem cells integrated biomaterials for bone and dental tissue engineering

Cited by 6 publications

References 59 publications

Biofabrication Approaches for Peri-Implantitis Tissue Regeneration: A Focus on Bioprinting Methods

Biofabrication Approaches for Peri-Implantitis Tissue Regeneration: A Focus on Bioprinting Methods

Zinc and Silver-Infused Calcium Silicate Cement: Unveiling Physicochemical Properties and In Vitro Biocompatibility

Dental Pulp-Derived Mesenchymal Stromal Cells

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