Tooth desensitizing calcium phosphate composite gelatin-based gel

Abstract

Dentine sensitivity is a dental problem common in individuals aged between 20 and 50 years. The most effective treatment method involves occluding the exposed dental tubules. This study focused on the synthesis of calcium phosphate nanoparticles in the form of gel to use as a proof of concept for home-treatment of sensitive teeth. In this study, calcium phosphate nanoparticles were prepared using emulsion method, in which oleic fatty acid was employed as an external phase, and sodium dodecyl sulphate (SDS) was used as a surfactant to form water-in-oil nanodroplets. Finally, in order to facilitate gel formation, the gelatin solution was introduced at the final step. The amount of gelatin varied from 5 to 15 percent by weight, which was found to have an effect on the gels’ properties and the size of calcium phosphate nanoparticles embedded in gel. Based on the characterization, the calcium phosphate nanoparticles were spherical in shape, though the size decreased as the amount of gelatin increased. The gel embedding smallest nanoparticle, that is, gel-15%G, was successfully proven to be non-toxic and able to fully occlude the dentine tubules only after overnight application. According to acid challenge, the occluded materials can resist to acid solution via redissolvation and reprecipitaion process.

The synthesis of Tween80/calcium phosphate nanocomposite bioactive gelatine-based gels as a proof of concept for tooth sensitivity home-treatment

“…The ability of the gel to occlude dentine tubules was tested in vitro using human dentine slices with the dimension of 1×1×0.15 cm according to a previously reported method 19) . First, the dentine slices were sonicated for 15 min in ethanol to clean them and then air dried.…”

Citric Acid Cross-Linked Gelatin-Based Composites with Improved Microhardness

“…Yan et al [ 12 ] reported that the addition of graphene oxide to gelatin/polyacrylamide hydrogels significantly improved their mechanical properties, including elastic modulus and fractured stress. Waiyawat et al [ 13 ] developed a gelatin-based gel containing calcium phosphate nanoparticles for treating dentine sensitivity. Belonging to the category of bioceramics, calcium phosphates (CaPs) exhibit outstanding biological, physical, and chemical properties owing to their composition, closely resembling that of compounds found in teeth and bones [ 14 , 15 , 16 ].…”