Top–down meets bottom–up: A comparison of the mechanical properties of melt electrospun and self-assembled 1,3,5-benzenetrisamide fibers

Kluge, Daniel; Singer, Julia C.; Neugirg, Benedikt R.; Neubauer, Jens W.; Schmidt, Hans‐Werner; Fery, Andreas

doi:10.1016/j.polymer.2012.10.016

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…Electrospinning of 1 (S) has been discussed briefly before . Due to the progressing evaporation of 1 (S) at temperatures above 290 °C, the spinning temperature ( T sp ) was set at 290 °C, only 1 K above the melting transition of 289 °C, and uniform nanofibers ( d fib = 0.5 ± 0.2 μm) were obtained as depicted in Table S1 (ESI).…”

Section: Resultsmentioning

confidence: 99%

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Melt Electrospinning of Small Molecules

Singer

Ringk

Giesa

et al. 2015

Macro Materials & Eng

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Electrospinning is an attractive way to prepare nano‐ and macrofibers. It was demonstrated by our group that trisamides can be melt electrospun into supramolecular fibers. To establish structure–property relationships regarding spinnability and morphology, melt electrospinning experiments were conducted using several classes of compounds. The number of hydrogen bonds was systematically decreased from three for trisamides, to two for bisamide and sorbitols, and to zero for perylene bisimides and tertiary trisamides. As a result, trisamides are readily spun into fibers, whereas for bisamides and sorbitols mainly electrospraying into spheres is observed. Perylene bisimides form well‐defined fibers due to strong π–π interactions. This supramolecular fiber is interesting for many scientific disciplines.

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Section: Resultsmentioning

confidence: 99%

“…Recently, we reported for the first time on the melt electrospinning of 1,3,5‐benzene‐ and 1,3,5‐cyclohexanetrisamides into long and homogenous fibers . Depending on core structure, amide connectivity to the core, and peripheral substituents, trisamides can exhibit thermotropic behavior and form mesophases .…”

Section: Introductionmentioning

confidence: 99%

Melt Electrospinning of Small Molecules

Singer

Ringk

Giesa

et al. 2015

Macro Materials & Eng

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“…In brief, electrospinning involves passing high voltage through a polymer solution such that a jet of liquid is deposited on a collector while simultaneously drying, wicking the polymer into the desired conformation [110]. Conversely, bottom-up approaches involve self-assembly from monomer units [111]. As a supramolecular structure, we will focus on the assembly of nano-and micro-fibers through bottom-up methods.…”

Section: Fibersmentioning

confidence: 99%

Protein based biomaterials for therapeutic and diagnostic applications

et al. 2021

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Proteins are some of the most versatile and studied macromolecules with extensive biomedical applications. The natural and biological origin of proteins offer such materials several advantages over their synthetic counterparts, such as innate bioactivity, recognition by cells and reduced immunogenic potential. Furthermore, proteins can be easily functionalized by altering their primary amino acid sequence and can often be further self-assembled into higher order structures either spontaneously or under specific environmental conditions. This review will feature the recent advances in protein-based biomaterials in the delivery of therapeutic cargo such as small molecules, genetic material, proteins, and cells. First, we will discuss the ways in which secondary structural motifs, the building blocks of more complex proteins, have unique properties that enable them to be useful for therapeutic delivery. Next, supramolecular assemblies, such as fibers, nanoparticles, and hydrogels, made from these building blocks that are engineered to behave in a cohesive manner, are discussed. Finally, we will cover additional modifications to protein materials that impart environmental responsiveness to materials. This includes the emerging field of protein molecular robots, and relatedly, protein-based theranostic materials that combine therapeutic potential with modern imaging modalities, including near-infrared fluorescence spectroscopy, single-photon emission computed tomography/computed tomography, positron emission tomography, magnetic resonance imaging, and ultrasound/photoacoustic imaging.

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“…Nanostructured materials can be synthesized with precisely controlled morphologies, sizes, and seemingly limitless chemical functional groups [ 42 ]. In contrast to bottom-up technologies, biocompatible-nanostructured surface has been fabricated with a top-down approach, via etching away bulk material to achieve the required smaller structural architectures [ 14 ] or through electrospinning by directly shaping the materials into the desired structure [ 43 ]. Electrospinning and novel direct-write 3D electrospinning technique, by enabling the production of micro/nanoscale-shaped structures such as continuous, self-aligned, fiber-by-fiber, and template-free manner fibers are showing growing potential in tissue engineering applications [ 44 ].…”

Section: Microfabrication and Nanolithography Techniques In Tementioning

confidence: 99%

Fabrication and Applications of Micro/Nanostructured Devices for Tissue Engineering

et al. 2016

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Nanotechnology allows the realization of new materials and devices with basic structural unit in the range of 1–100 nm and characterized by gaining control at the atomic, molecular, and supramolecular level. Reducing the dimensions of a material into the nanoscale range usually results in the change of its physiochemical properties such as reactivity, crystallinity, and solubility. This review treats the convergence of last research news at the interface of nanostructured biomaterials and tissue engineering for emerging biomedical technologies such as scaffolding and tissue regeneration. The present review is organized into three main sections. The introduction concerns an overview of the increasing utility of nanostructured materials in the field of tissue engineering. It elucidates how nanotechnology, by working in the submicron length scale, assures the realization of a biocompatible interface that is able to reproduce the physiological cell–matrix interaction. The second, more technical section, concerns the design and fabrication of biocompatible surface characterized by micro- and submicroscale features, using microfabrication, nanolithography, and miscellaneous nanolithographic techniques. In the last part, we review the ongoing tissue engineering application of nanostructured materials and scaffolds in different fields such as neurology, cardiology, orthopedics, and skin tissue regeneration.

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Top–down meets bottom–up: A comparison of the mechanical properties of melt electrospun and self-assembled 1,3,5-benzenetrisamide fibers

Cited by 9 publications

References 46 publications

Melt Electrospinning of Small Molecules

Melt Electrospinning of Small Molecules

Protein based biomaterials for therapeutic and diagnostic applications

Fabrication and Applications of Micro/Nanostructured Devices for Tissue Engineering

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