Topical 0.1% Indomethacin Solution versus Topical 0.1% Dexamethasone Solution in the Prevention of Inflammation after Cataract Surgery

Missotten, Luc; Richard, C.; Trinquand, C.

doi:10.1159/000050825

Cited by 19 publications

(13 citation statements)

References 9 publications

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“…Anti-inflammatory effects from topically applied NSAIDs in eyes undergoing cataract surgery have been demonstrated in many randomized, prospective, double-masked controlled clinical studies. Measurable effects could be shown for diclofenac 0.1%, ketorolac 0.5%, indomethacin 1% and flurbiprofen 0.03% after extra- and intracapsular cataract extraction with and without implantation of an IOL [14, 15, 64, 65, 66, 67, 68, 69]. …”

Section: Inflammation After Cataract Surgerymentioning

confidence: 99%

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Schalnus

2003

Ophthalmologica

143

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Topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management and prevention of ocular inflammation and cystoid macular edema related to cataract surgery and the maintenance of mydriasis during cataract surgery. Other common uses are the reduction of discomfort after refractive surgery or in allergic conjunctivitis. NSAIDs primarily act as cyclooxygenase inhibitors and thus reduce the formation of endogenous PGs. Today, several NSAIDs are commercially available: diclofenac, flurbiprofen, indomethacin, ketorolac and suprofen. At present the ophthalmologist has to make a decision between the use of topical corticosteroids, with their potential adverse effects, or of topical NSAIDs, with their possibly increased benefit, unknown effect on ocular pressure, wound healing and corneal tissue, higher costs and limited track record. However, the improvement of surgical techniques might support an increasing use of NSAIDs in the future. Preoperative anti-inflammatory treatment should be considered in eyes at a higher risk of developing severe postoperative inflammatory reactions. This decision has to be made carefully and has to be guided by the clinical circumstances, the spectrum of diagnosis and the individual benefit-risk ratio of each patient.

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Section: Inflammation After Cataract Surgerymentioning

confidence: 99%

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Schalnus

2003

Ophthalmologica

143

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“…Steroids and nonsteroidal inflammatory drugs (NSAIDs) are used in the prophylaxis and treatment of pain and inflammation associated with cataract surgery, either alone or as combination therapy [7][8][9][10][11]. In a 2014 ASCRS clinical survey [12], 41.2% of the 1,500 ophthalmic surgeons strongly agreed that low-to-moderate levels of intraocular inflammation can significantly impact postoperative visual acuity and visual quality.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Sustained Release Dexamethasone for the Treatment of Ocular Pain and Inflammation after Cataract Surgery: Results from Two Phase 3 Studies

Walters¹,

Bafna²,

Vold³

et al. 2016

J Clin Exp Ophthalmol

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“…The 'efficacy rate' was defined as the percentage of patients displaying absent (score ¼ 0) or mild (score ¼ 1) degree of AC flare. 22 The 'percentage of responders' was defined as the percentage of patients showing a decrease of AC flare score from baseline and those scoring 0 at baseline and also at the end point. 22 The study was designed to show that dexamethasone/ netilmicin was not inferior to TOBRADEX s .…”

Section: Statisticsmentioning

confidence: 99%

“…22 The 'percentage of responders' was defined as the percentage of patients showing a decrease of AC flare score from baseline and those scoring 0 at baseline and also at the end point. 22 The study was designed to show that dexamethasone/ netilmicin was not inferior to TOBRADEX s . Analysis of efficacy was performed by means of one-sided 97.5%-confidence intervals test, with a delta of 15%, a power of 90% and a lower margin of À15.…”

Section: Statisticsmentioning

confidence: 99%

Dexamethasone–netilmicin: a new ophthalmic steroid–antibiotic combination. Efficacy and safety after cataract surgery

Russo¹,

Papa²,

Bella³

et al. 2005

Eye

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Purpose The purpose of this study was to evaluate both efficacy and safety of a new ophthalmic steroid-antibiotic fixed combination containing dexamethasone and netilmicin in the postsurgical management of cataract surgery. Methods In total, 223 patients were randomly treated with dexamethasone 1 mg/ml plus netilmicin 3 mg/ml (n ¼ 148), or dexamethasone 1 mg/ml plus tobramycin 3 mg/ ml (n ¼ 75, TOBRADEX s ) four times in a day for 771 days starting immediately after surgery. Efficacy (anterior chamber (AC) inflammation, conjunctival hyperaemia, corneal and lid oedema, ocular infection, pain, photophobia and tearing) and safety (burning, stinging, blurred vision, intraocular pressure, and visual acuity) were analysed in the operated eye after 1 and 771 days. A followup visit was performed at day 1472. The extent of AC inflammation, measured by slitlamp according to a standard scoring system, was used as primary efficacy parameter. Results At the primary end point (day 7) both fixed combinations were equally effective in reducing postoperative inflammation. The safety profile of the dexamethasone/netilmicin combination was excellent with no evidence of poor local tolerance or adverse reaction. Conclusions A new fixed combination of dexamethasone and netilmicin was effective and safe in controlling ocular inflammation after cataract surgery.

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Topical 0.1% Indomethacin Solution versus Topical 0.1% Dexamethasone Solution in the Prevention of Inflammation after Cataract Surgery

Cited by 19 publications

References 9 publications

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Topical Nonsteroidal Anti-Inflammatory Therapy in Ophthalmology

Efficacy and Safety of Sustained Release Dexamethasone for the Treatment of Ocular Pain and Inflammation after Cataract Surgery: Results from Two Phase 3 Studies

Dexamethasone–netilmicin: a new ophthalmic steroid–antibiotic combination. Efficacy and safety after cataract surgery

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