Topical 10% Zinc Sulfate Solution for Treatment of Melasma

Sharquie, Khalifa E.; Al-Mashhadani, Sabeeh A.; Salman, Hussam Ali

doi:10.1111/j.1524-4725.2008.34287.x

Cited by 31 publications

(26 citation statements)

References 8 publications

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“…[1415] It has been suggested that zinc elements play role by anti-inflammatory, anti-oxidant, and healing effect. [11] In the present study, to our knowledge, we provide the first clinical evidence that compares quantitatively the effectiveness of topical 10% zinc sulfate and 4% hydroquinone cream in the treatment of melasma.…”

Section: Discussionmentioning

confidence: 99%

“…[1112] Zinc sulfate was found to be effective in treatment of many dermatological disorders, such as cutaneous leishmaniasis, recurrent herpes simplex, common and genital warts and recently melasma. [1121415] In fact, there is only one study that has been conducted on the efficacy of topical zinc sulfate for the treatment of melasma. [1415] This study is the first, to our knowledge, to measure quantitatively the difference between the efficacy of conventional treatment with hydroquinone and the newly proposed agent, topical zinc sulfate solution in the treatment of melasma.…”

Section: Introductionmentioning

confidence: 99%

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Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma

2012

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Background:Melasma, a common disorder of hyperpigmentation, is often difficult to treat. Although 10% zinc sulfate solution has been reported to be useful for patients with melasma, controlled trials are lacking.Materials and Methods:72 women with moderate to severe melasma were divided randomly into 2 groups. Group A were treated with 10% zinc sulfate solution and group B with 4% hydroquinone cream twice-daily. The results were evaluated by photoevaluation by patients based on subjective satisfaction and a blinded dermatologist using MASI score. Assessments were obtained at baseline and at 2 and 6 months after starting treatment.Results:According to MASI score changes during treatment, there was a reduction in both groups at 2 months, however, the reduction in group B was more significant (the reduction in mean ± SD MASI was 0.7 ± 0.7 in group A vs. 2.7 ± 1.6 in group B). In addition, the patients in group B continued to decrease MASI score for the remainder of the study period at 6 months follow-up (0.3 ± 0.5) in comparison with patients in group A who did not show more reduction in MASI score.Conclusions:The study indicates that topical zinc sulfate is not as effective in treating disease as was observed in the previous open study. A comparative study with sunscreen and placebo is necessary to determine if topical zinc sulfate is truly superior to sunscreen and placebo in this respect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma

2012

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“…Topical zinc sulphate has also been tried in the management of melasma owing to its peeling and sunscreen properties. Sharquie et al [80] reported a significant reduction in MASI (melasma area and severity index) scores in 14 melasma patients after three months of therapy with 10% topical zinc sulphate without any significant adverse effects. However, this mode of treatment did not find much favor as results could not be reproduced in other studies and no statistically significant improvement was seen with topical zinc therapy [81, 82].…”

Section: Pigmentary Disordersmentioning

confidence: 99%

Zinc Therapy in Dermatology: A Review

Gupta¹,

Mahajan²,

Mehta³

et al. 2014

Dermatology Research and Practice

228

178

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Zinc, both in elemental or in its salt forms, has been used as a therapeutic modality for centuries. Topical preparations like zinc oxide, calamine, or zinc pyrithione have been in use as photoprotecting, soothing agents or as active ingredient of antidandruff shampoos. Its use has expanded manifold over the years for a number of dermatological conditions including infections (leishmaniasis, warts), inflammatory dermatoses (acne vulgaris, rosacea), pigmentary disorders (melasma), and neoplasias (basal cell carcinoma). Although the role of oral zinc is well-established in human zinc deficiency syndromes including acrodermatitis enteropathica, it is only in recent years that importance of zinc as a micronutrient essential for infant growth and development has been recognized. The paper reviews various dermatological uses of zinc.

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“…Of important note, vitamin B12 deficiency must be ruled out if a patient supplements with more than 1 mg per day because vitamin B12 deficiency and high serum folate are associated with an increased risk of cognitive impairment and anemia in adults (Selhub et al 2007). Also, patients with SOC are at a higher risk of melasma during pregnancy so photoprotection of the face is important during light therapy (Sharquie et al 2008). …”

Section: Special Considerationsmentioning

confidence: 99%

Dermatologic conditions in patients of color who are pregnant

Jeon

Agbai

Butler

et al. 2017

International Journal of Women's Dermatology

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Certain dermatoses that present during pregnancy have a predilection for populations with skin of color (SOC). Additionally, certain systemic diseases such as systemic lupus erythematosus tend to be more aggressive during pregnancy and confer worse prognoses in women with SOC. The purpose of this review is to highlight the unique implications of selected diseases during pregnancy as it relates to SOC. Dermatologists should be vigilant for the unique clinical variations of dermatological conditions in patients of color who are pregnant to ensure correct diagnoses and optimize treatment outcomes.

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Topical 10% Zinc Sulfate Solution for Treatment of Melasma

Abstract: Topical 10% zinc sulfate solution is a new effective, safe, and noncostly formulation in the treatment of melasma.

Cited by 31 publications

References 8 publications

Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma

Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma

Zinc Therapy in Dermatology: A Review

Dermatologic conditions in patients of color who are pregnant

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