Topical 5-fluorouracil solution in the treatment of warts—clinical experience and percutaneous absorption

Senff, H.; Reinel, D.; Matthies, Cordula; Witts, D.

doi:10.1111/j.1365-2133.1988.tb02436.x

Cited by 19 publications

(7 citation statements)

References 6 publications

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“…Medications containing 5‐fluorouracil have been reported to be effective in the treatment of genital and extragenital warts . Salicylic acid increases the penetration and efficacy of 5‐FU because it is keratolytic in nature.…”

Section: Discussionmentioning

confidence: 99%

A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

et al. 2014

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Anogenital warts are caused by human papillomavirus (HPV), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH) solution with that of a topical 0.5% 5‐fluorouracil (5‐FU) and 10% salicylic acid (SA) combination in the treatment of anogenital warts. Sixty patients were randomly assigned to receive topical KOH or 5‐FU + SA. Both groups demonstrated a significant decrease in numbers of lesions (P < 0.05), but this difference was not significant at week 12 (P > 0.05). The mean number of lesions decreased from baseline to week 12 from 17.03 ± 12.64 to 3.73 ± 7.30 and from 16.13 ± 12.97 to 3.10 ± 4.90 in the KOH and 5‐FU + SA groups, respectively (P < 0.001). Excellent clearance was achieved by 70.0 and 76.7% of patients in the KOH and 5‐FU + SA groups, respectively. Marked improvement was seen in 13.3 and 20.0% of patients in the KOH and 5‐FU + SA groups, respectively. At week 16, relapse was observed in two patients in the KOH group and three in the 5‐FU + SA group (P > 0.05). No serious adverse events were reported. Neither treatment was more efficacious. Safety and ease of application are important goals in treatments for anogenital warts. A 5% KOH solution is a promising alternative treatment because it is effective and inexpensive and causes minimal side effects.

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Section: Discussionmentioning

confidence: 99%

A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

et al. 2014

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“…Absorption of topical 5-FU through intact cutaneous surfaces is thought to be minimal [4,5]. A study comparing the 0.5 and 5% creams revealed lower levels of systemic absorption in the 0.5% arm compared to the 5% arm [6].…”

Section: Topical 5-fluorouracilmentioning

confidence: 97%

Topical Antineoplastic Agents in the Treatment of Mucocutaneous Diseases

Grossberg

Gaspari

2011

Topical Applications and the Mucosa

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Topical antineoplastic agents have a well-established role in the treatment of several dermatological conditions. Their use in the treatment of mucosal skin disease also has gained increasing recognition. Topical 5-fluorouracil (5-FU), an antimetabolite, and imiquimod, an immunomodulatory agent with antitumor properties, are the two principal topical antineoplastic agents used in the treatment of mucocutaneous diseases. Although the vast majority of their mucosal uses are currently not approved by the Federal Drug Administration, there are numerous case series, open-label studies and randomized controlled trials supporting their uses in the treatment of mucocutaneous diseases. Both topical 5-FU and imiquimod have been successfully utilized in the treatment of a wide range of mucosal diseases, including actinic cheilitis, Bowen's disease of the anal and vulvar mucosa, and genital and perianal condyloma. Reports of their uses in the treatment of mucocutaneous diseases indicate that these agents can be safely administered, though adverse effects such as local inflammation may be augmented when these agents are applied to mucosal surfaces. Additionally, locally acting intralesional chemotherapeutic agents, such as bleomycin and interferon, have well-defined applications in the treatment of mucosal skin diseases such as condyloma acuminata. As further studies are conducted, these topical and intralesional neoplastic agents, in addition to emerging agents that are in various stages of development, such as Toll-like receptor 9 agonists and ingenol mebutate, may play an increasingly important role in the future treatment of mucocutaneous diseases.

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“…In der letztgenannten Analyse waren jedoch auch die Abheilungsraten unter Plazebo‐Behandlung mit 48 % erheblich höher, so daß hieraus nicht auf eine größere Wirksamkeit der Salicylsäure‐Monotherapie geschlossen werden darf. Vielmehr bestätigen die vorliegenden Daten klinische Beobachtungen [31], daß durch Zusatz von 5‐FU eine gesteigerte Wirksamkeit der Salicylsäure‐Zubereitung zu erwarten ist. Weitere Faktoren wie die Begleittherapien, Art und Größe der Warzenareale, Drop‐outs sowie die Behandlungsdauer sind zusätzliche Einflußgrößen, die die Vergleichbarkeit der Studien und damit der Metaanalysen erschweren.…”

Section: Diskussionunclassified

Wirksamkeit und Nutzen eines 5‐FU‐/Salicylsäure‐haltigen Präparates in der Therapie vulgärer und plantarer Warzen – systematische Literaturübersicht und Metaanalyse

Zschocke¹,

Hartmann²,

Schlöbe³

et al. 2004

J Deutsche Derma Gesell

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Topical 5-fluorouracil solution in the treatment of warts—clinical experience and percutaneous absorption

Cited by 19 publications

References 6 publications

A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

Topical Antineoplastic Agents in the Treatment of Mucocutaneous Diseases

Wirksamkeit und Nutzen eines 5‐FU‐/Salicylsäure‐haltigen Präparates in der Therapie vulgärer und plantarer Warzen – systematische Literaturübersicht und Metaanalyse

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