Topical 5% minoxidil versus topical 0.2% glyceryl trinitrate in treatment of chronic anal fissure: A randomized clinical trial

Emile, Sameh Hany; Abdel-Razik, Mohamed Anwar; Elshobaky, Ayman; Elbaz, Samy Abbas; Khafagy, Wael; Shalaby, Mostafa

doi:10.1016/j.ijsu.2020.01.143

Cited by 5 publications

(1 citation statement)

References 24 publications

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“…Four topical treatments for chronic anal fissures were tested and were effective in reducing pain in these patients for up to 2 months of daily application, particularly diltiazem 93,94 , minoxidil 94,95 , glyceryl trinitrate 95 , and Levorag 96 -and adverse effects include mostly itching right after application, which usually subsides. The local administration of different analgesics has been tested for pain control, with minimal side effects -intra-articular lidocaine in osteoarthritis 97 and intramuscular for myofascial pain syndrome patients 98 , intra-articular capsaicin in patients with osteoarthritis 99 , and intradiscal ketamine 100 and transforaminal ropivacaine 46 in patients with low back pain.…”

Section: Pharmacological Treatments For Chronic Musculoskeletal and V...mentioning

confidence: 99%

Recent advances in the pharmacological treatment of chronic pain: a systematic review

Fonseca-Rodrigues,

Almeida,

Pinto-Ribeiro

2024

DOR

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Chronic pain is one of the most important public health concerns, greatly impacting the patients' quality of life and with high societal and economical costs. Despite advances in the understanding of pain mechanisms and the establishment of several strategies to decrease pain severity in patients, there continues to be a substantial proportion of patients who are refractory to the currently available treatments. Recently, novel pharmacological strategies have been developed for the treatment/ management of chronic pain, directed at symptoms and psychological complications of the illness. In this work, we performed a systematic review of the recent advances in pharmacological strategies for chronic pain. For that purpose, we searched a total of four databases (PubMed, Science Direct, Web of Science, and Scopus) for clinical trials testing drugs in patients with chronic pain, completed between the years 2017 and 2021 (1 st January 2017 up to 17 th November 2021). The different treatments were analysed and compared regarding their effectiveness, indications, and side effects. We included 166 studies, which provided information on 46 796 participants, mostly women (64%). This review pools together data on novel drug therapeutic strategies or improved applications of already known drugs, from opioids to monoclonal antibodies, providing researchers and health professionals with tools to ameliorate human chronic pain research and management.

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