Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp

Kastarinen, Helena; Oksanen, Tuija; Okokon, Enembe O.; Kiviniemi, Vesa; Airola, Kristiina; Jyrkkä, Johanna; Oravilahti, Tuomas; Rannanheimo, Piia; Verbeek, Jos

doi:10.1002/14651858.cd009446.pub2

Cited by 32 publications

(28 citation statements)

References 62 publications

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“…Treatment selection should consider drug efficacy, level 1b) . For mild forms, a topical approach is recommended starting with ketoconazole or ciclopirox, or alternatively selenium sulphide/zinc pyrithione, or keratolytic shampoos [8,52] . Similarly to non-scalp SD [53][54][55][56] , non-steroidal and anti-inflammatory with antifungal properties (AIAFp) shampoo may represent a viable option, as reported in a recent randomized, single-blind clinical trial [57] .…”

Section: Sd Of the Scalp And Hairy Areasmentioning

confidence: 99%

“…Similarly to non-scalp SD [53][54][55][56] , non-steroidal and anti-inflammatory with antifungal properties (AIAFp) shampoo may represent a viable option, as reported in a recent randomized, single-blind clinical trial [57] . In case of failure, add a 4-week course with a weak-to-moderately potent corticosteroid [class I and II according to the Anatomical Therapeutic Chemical (ATC) classification by the World Health Organization (WHO)] followed by its gradual discontinuation [52] .…”

Section: Sd Of the Scalp And Hairy Areasmentioning

confidence: 99%

“…For moderate-to-severe forms, especially if itchy, a combination of antifungal or AIAFp shampoo with weakto-moderately potent (class I-II) topical corticosteroids for up to 4 weeks is recommended [52] ; in case of no improvement, consider to include in the weekly routine treatment with antifungal or AIAFp shampoo, 2 days of potent-to-very potent topical corticosteroid shampoo (class III and IV), containing fluocinolone acetonide 0.01% (class III) or clobetasol propionate 0.05% (class IV) for up to 2 weeks [45,[58][59][60] (category A, level 1b). In case of more resistant disease, systemic antifungals may be added [47,48] .…”

Section: Sd Of the Scalp And Hairy Areasmentioning

confidence: 99%

“…For the treatment of mild, non-scalp SD in adults, especially on the face, the use of antifungal creams (e.g., ketoconazole 2% cream, ciclopirox 1% cream) or AIAFp cream is preferred [52] . Topical antifungals represent the most common approach, and in the past years AIAFp cream has clearly demonstrated efficacy and tolerability in the treatment of mild-to-moderate SD of the face [53][54][55][56]61] (category A, level 1b) .…”

Section: Sd Of Non-scalp Areasmentioning

confidence: 99%

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Treatment of Seborrhoeic Dermatitis in Asia: A Consensus Guide

Cheong

Yeung

Torsekar

et al. 2015

Skin Appendage Disord

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Seborrhoeic dermatitis (SD) is common in Asia. Its prevalence is estimated to be 1-5% in adults. However, larger population-based studies into the epidemiology of SD in Asia are lacking, and the aetiology of SD may differ widely from Western countries and in different parts of Asia. In addition, clinically significant differences between Asian and Caucasian skin have been reported. There is a need to define standardized clinical diagnostic criteria and/or a grading system to help determine appropriate treatments for SD within Asia. With this in mind, experts from India, South Korea, Taiwan, Malaysia, Vietnam, Singapore, Thailand, the Philippines, Indonesia, and Italy convened to define the landscape of SD in Asia at a meeting held in Singapore. The consensus group developed a comprehensive algorithm to aid clinicians to recommend appropriate treatment of SD in both adults and children. In most cases, satisfactory therapeutic results can be accomplished with topical antifungal agents or topical corticosteroids. Non-steroidal anti-inflammatory agents with antifungal properties have been shown to be a viable option for both acute and maintenance therapy.

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Section: Sd Of the Scalp And Hairy Areasmentioning

confidence: 99%

Section: Sd Of the Scalp And Hairy Areasmentioning

confidence: 99%

Section: Sd Of the Scalp And Hairy Areasmentioning

confidence: 99%

Section: Sd Of Non-scalp Areasmentioning

confidence: 99%

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Treatment of Seborrhoeic Dermatitis in Asia: A Consensus Guide

Cheong

Yeung

Torsekar

et al. 2015

Skin Appendage Disord

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“…Acute tinea pedis appears to respond rapidly to ceramide-containing cream-more rapidly, in fact, than to antifungal creams (8-12 hours versus 36-72 hours for antifungals) [21]. This response is similar to that described by O'Brien upon applying lanolin to lesions of miliaria with subsequent clearing of lesions and resumption of sweat production [23]. Seborrheic dermatitis is also effectively treated with topical steroids [24].…”

Section: Discussionmentioning

confidence: 90%

Eccrine Sweat Duct Occlusion by Staphylococcal-Derived Biofilms: An Unexpected Signature Finding of Eczema in Dermatologic Diseases

Allen¹,

TS²,

SP³

2015

Clin Exp Dermatol Res

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We believe that axillary granular parakeratosis, tinea pedis, and Seborrheic dermatitis are likely to be variants of eczema. All had culturable staphylococci capable of producing biofilms, as in eczema. This was confirmed on XTT assays, Congo red cultures, and PCR for gene analysis of the biofilm-forming icaD and aap genes. The pathology showed eccrine ductal occlusion that was noted on H+E and PAS stains (PAS stains positively the extracellular polysaccharide substance that makes up the bulk of the biofilm.) Toll-like receptor 2 (TLR 2) activities was found in the stratum corneum adjacent to the sweat ducts and not in its control location in the basal zone. The stratum corneum seemingly becomes altered by the fungi, yeasts, or tiny granules instead of by the filaggrin gene (1 st in the double hit phenomenon); and, the sweat ducts become occluded causing activation of TLR 2. This leads to activation of the innate immune system (2 nd hit), just as in eczema. Further, treatment with the mild topical corticoids and/or moisturizers helps restore the integrity of the skin.

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Topical Anti-inflammatory Agents for Seborrheic Dermatitis of the Face or Scalp

2015

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The topical anti-inflammatory treatments were more effective in achieving total clearance of symptoms than placebo by 1.4-fold to 8.5-fold, but there are no considerable differences in the anti-inflammatory topical treatments or in comparison with azoles for short-term treatment. There is no evidence of treatment effects in long-term, continuous, or intermittent use of these compounds despite the chronic nature of the disease.

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Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp

Abstract: Trusted evidence. Informed decisions. Better health.

Cited by 32 publications

References 62 publications

Treatment of Seborrhoeic Dermatitis in Asia: A Consensus Guide

Treatment of Seborrhoeic Dermatitis in Asia: A Consensus Guide

Eccrine Sweat Duct Occlusion by Staphylococcal-Derived Biofilms: An Unexpected Signature Finding of Eczema in Dermatologic Diseases

Topical Anti-inflammatory Agents for Seborrheic Dermatitis of the Face or Scalp

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