Topical antirheumatic agents as hydroxyl radical scavengers

Billany, M.R.; Denman, Sara; Jameel, Suzana; Sugden, J. K.

doi:10.1016/0378-5173(95)00099-5

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…It is increasingly recognized that ROS such as hydroxyl radicals, hydrogen peroxide and HOCl are involved in rheumatoid arthritis [59]. In accordance with it, some antioxidant compounds [60][61][62] have provided protective effects in some arthritis models and has been ascribed to its antioxidant properties. Zymosan is well known as a powerful releaser of AA metabolites that contribute actively to the early phase of inflammatory reaction [63].…”

Section: Anti-inflammatory Effects Of Phyco-cyaninmentioning

confidence: 91%

C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects

Romay¹,

González

Ledón³

et al. 2003

CPPS

593

307

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Phycocyanin (Pc) is a phycobiliprotein that has been recently reported to exhibit a variety of pharmacological properties. In this regard, antioxidant, anti-inflammatory, neuroprotective and hepatoprotective effects have been experimentally attributed to Pc. When it was evaluated as an antioxidant in vitro, it was able to scavenge alkoxyl, hydroxyl and peroxyl radicals and to react with peroxinitrite (ONOO(-);) and hypochlorous acid (HOCl). Pc also inhibits microsomal lipid peroxidation induced by Fe(+2)-ascorbic acid or the free radical initiator 2,2' azobis (2-amidinopropane) hydrochloride (AAPH). Furthermore, it reduces carbon tetrachloride (CCl(4))-induced lipid peroxidation in vivo. Pc has been evaluated in twelve experimental models of inflammation and exerted anti-inflammatory effects in a dose-dependent fashion in all of these. Thus, Pc reduced edema, histamine (Hi) release, myeloperoxidase (MPO) activity and the levels of prostaglandin (PGE(2)) and leukotriene (LTB(4)) in the inflamed tissues. These anti-inflammatory effects of Pc can be due to its scavenging properties toward oxygen reactive species (ROS) and its inhibitory effects on cyclooxygenase 2 (COX-2) activity and on Hi release from mast cells. Pc also reduced the levels of tumor necrosis factor (TNF-alpha) in the blood serum of mice treated with endotoxin and it showed neuroprotective effects in rat cerebellar granule cell cultures and in kainate-induced brain injury in rats.

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Section: Anti-inflammatory Effects Of Phyco-cyaninmentioning

confidence: 91%

C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects

Romay¹,

González

Ledón³

et al. 2003

CPPS

593

307

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“…ketoprofen21 and Articular histological lesions of the knee in zymosan-induced arthritis in mice treated with Spirulina…”

mentioning

confidence: 99%

Inhibitory effects of Spirulina in zymosan‐induced arthritis in mice

Remírez¹,

González²,

Merino³

et al. 2002

Mediators of Inflammation

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The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg perorally) was administered to animals for 8 days. The mice were than killed and beta-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of beta-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, whereas no destruction of cartilage, well-preserved chondrocytes, and normal rough endoplasmic reticulum and mitochondria were seen. The anti-arthritic effect exerted by Spirulina as shown in this model may be at least partly due to the previously reported antiinflammatory and antioxidative properties of its constituent, phycocyanin. To our knowledge, this is the first report on the anti-inflammatory effect of Spirulina in an experimental model of arthritis.

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“…*P < 0.05 vs. group treated only with zymosan. N-acetyl cysteine [Kroger et al, 1997], ketoprofen [Billany et al, 1995], and CV-3611 [Chikanza et al, 1998], have provided protective effects in some arthritis models and ascribed to its antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

Effect of phycocyanin in zymosan‐induced arthritis in mice—phycocyanin as an antiarthritic compound

Remírez¹,

González²,

Merino³

et al. 1999

Drug Dev. Res.

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The antiinflammatory effect of a phycocyanin extract was studied in zymosan-induced arthritis model in mice. Four days after the intraarticular injection of zymosan, (15 mg/ml), phycocyanin (25, 50, and 100 mg/kg p.o) was administered to animals for 8 days. The mice were then killed and the synovial fluid measured for β-glucuronidase. Each knee joint was totally removed for histopathological and ultrastructural studies. Phycocyanin significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition in cellular infiltration and reduction of synovial hyperplasia and synovitis. The antiinflammatory activity exerted by phycocyanin may be due, at least in part, to its antioxidative properties, although inhibitory effects on both arachidonic acid metabolism and cytokine production such as tumor necrosis factor (TNF) may also be involved. To our knowledge, this is the first report on the antiinflammatory effect of phycocyanin in an experimental model of arthritis. Drug Dev. Res. 48:70-75, 1999.

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Topical antirheumatic agents as hydroxyl radical scavengers

Cited by 10 publications

References 3 publications

C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects

C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects

Inhibitory effects of Spirulina in zymosan‐induced arthritis in mice

Effect of phycocyanin in zymosan‐induced arthritis in mice—phycocyanin as an antiarthritic compound

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