Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density

Abstract

Summary Background The combination of oral supplementation and topical formulations to the improvement of skin conditions has been proposed as an innovative approach to obtain effective treatments. However, studies comparing the effectiveness of each type of treatments are still in lack. This way, the objective of this work was to evaluate the clinical efficacy of a dermocosmetic formulation with di‐ and tripeptides, as well the effects of an oral supplementation based on hydrolyzed collagen through biophysical and skin imaging techniques. Methods Sixty healthy female subjects, aged between 40 and 50 years, were enrolled, being separated in 3 groups: topical formulation, oral supplementation, and oral placebo. The stratum corneum water content, skin viscoelasticity, dermis echogenicity, and skin pores parameters were evaluated. Results The group with the topical formulation showed a significant increase in the stratum corneum water content and skin elasticity after 28‐day period and also acted in the dermis echogenicity after 90 days with the formulation with peptides. The oral supplementation acted on skin elasticity and presented a more pronounced effect on dermis echogenicity, reducing skin pores after 90‐day period. Conclusion The obtained results with oral supplementation and topical application of hydrolyzed proteins were considered complementary in the improvement of general skin conditions, acting in different mechanisms.

Hydrolyzed Collagen—Sources and Applications

“…A study of sixty healthy female subjects, aged between 40 and 50 years, after 28 days of oral supplementation showed that this acted on skin elasticity and presented a more pronounced effect on dermis echogenicity, reducing skin pores, improving hydration, texture, elasticity, and firmness of the skin. The oral supplementation product was composed of HC with a mix of vitamins A, C, E, and zinc [126]. HC from tilapia fish scale ( Oreochromis mosambicus ) in the form of 20 mL beverage (Nitta Gelatin Inc ® ., India) was consumed by healthy women aged 30–60 years over 12 weeks, after this time the result was enhanced facial skin moisture [127].…”

Collagen Based Materials in Cosmetic Applications: A Review

“…Enzymatic hydrolysis was selected for recovering these by-products with high value-added. The moisturizing properties of hydrolyzed collagen in deeper levels of the skin are very high and may give a very good effect on the looks of the skin [ 72 , 73 , 74 ]. In its hydrolyzed form, collagen is a widely known cosmetic component with antioxidant properties [ 72 ].…”

“…Hydrolyzed collagen acts as a natural humectant with an excellent potential of becoming a harmless and useful biomaterial. It has been shown that supplementation and topical application of hydrolyzed proteins can be considered complementary in the improvement of general skin condition, participating in different mechanisms [ 73 ]. The review of sources and application of hydrolyzed collagen has been performed by León-López et al [ 75 ].…”

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

“…Innovative studies have been carried out with the combination of topical application of peptides extracted from rice and oral supplementation of HC mixed with vitamin A, C, D, and Zinc. This study was developed in 60 healthy female subjects by applying biophysical and skin imaging techniques [128]. The levels of hydration at deeper layers of the epidermis were improved after one month by the topic application of cosmetic formulation with peptides.…”