Topical capsaicin patch for pain management in PTEN hamartoma tumor syndromes

Silva-Clavería, Francisca; Bernabéu‐Wittel, José; Monserrat, María T.

doi:10.1111/ddg.14826

J Deutsche Derma Gesell

2022

DOI: 10.1111/ddg.14826

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Topical capsaicin patch for pain management in PTEN hamartoma tumor syndromes

Francisca Silva-Clavería

José Bernabéu‐Wittel

María T. Monserrat

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2024

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Capsaicin: Emerging Pharmacological and Therapeutic Insights

Petran,

Periferakis,

Troumpata

et al. 2024

CIMB

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Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin is hepatically metabolised, having a half-life correlated with the method of application. Research on various applications of capsaicin in different formulations is still ongoing. Thus, local capsaicin applications have a pronounced anti-inflammatory effect, while systemic applications have a multitude of different effects because their increased lipophilic character ensures their augmented bioavailability. Furthermore, various teams have documented capsaicin’s anti-cancer effects, proven both in vivo and in vitro designs. A notable constraint in the therapeutic effects of capsaicin is its increased toxicity, especially in sensitive tissues. Regarding the traditional applications of capsaicin, apart from all the effects recorded as medicinal effects, the application of capsaicin in acupuncture points has been demonstrated to be effective and the combination of acupuncture and capsaicin warrants further research. Finally, capsaicin has demonstrated antimicrobial effects, which can supplement its anti-inflammatory and anti-carcinogenic actions.

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Capsaicin: Emerging Pharmacological and Therapeutic Insights

Petran,

Periferakis,

Troumpata

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

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Topical capsaicin patch for pain management in PTEN hamartoma tumor syndromes

Cited by 1 publication

References 11 publications

Capsaicin: Emerging Pharmacological and Therapeutic Insights

Capsaicin: Emerging Pharmacological and Therapeutic Insights

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