Topical Cyclosporine A 1% for the Treatment of Chronic Ocular Surface Inflammation

Ragam, Ashwinee; Kolomeyer, Anton M.; Kim, Jason; Nayak, Natasha V.; Fang, Christina H.; Kim, Eliott; Chu, David

doi:10.1097/icl.0000000000000055

Cited by 17 publications

(9 citation statements)

References 28 publications

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“…47 Thus, vitamin A not only ameliorates the symptoms of dry eye but also enhances the smoothness and stability of the ocular tear film and supports tear production. 45,48 As opposed to the above-mentioned studies, one study showed that oral omega-3 supplements were more effective than were oral vitamin A supplements for the management of dry eye syndrome. 49 Moreover, it has been shown that some eye drops cause allergy and last only for a short period of time.…”

Section: Discussionmentioning

confidence: 99%

<p>Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye</p>

Alanazi¹,

El‐Hiti²,

Al-Baloud³

et al. 2019

OPTH

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Objective: To investigate the effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye. Methods: In total, 30 male patients with dry eye (age range, 18-38 years; mean age, 25.2±2.8 years) who did not wear contact lenses or exhibit any ocular (other than dry eye) or systemic diseases were included, along with 30 age-matched men (control group; mean age, 24.5±2.3 years) with healthy eyes. Subject exclusion was based on the findings of the McMonnies questionnaire (cutoff score for dry eye: 14.5) and slit-lamp biomicroscopy. All subjects received an oral vitamin A supplement at a daily dose of 1,500 mg for 3 consecutive days. The phenol red thread (PRT) test was performed along with assessments of tear ferning (TF), tear osmolarity, and the tear break-up time (TBUT) before and 24 hours after the third dose of the vitamin A supplement. A 10-minute interval was observed between different tests. Results: In the dry eye group, the TF grade (Wilcoxon test, P=0.01) exhibited a significant decrease, while the tear osmolarity value (t-test, P=0.01) exhibited a significant increase after vitamin A supplementation. The PRT test findings (P=0.17) and TBUT (P=0.49) showed no significant differences before and after vitamin A supplementation. In the control group, vitamin A supplementation showed no significant effects on TF (P=0.74), tear osmolarity (P=0.55), the TBUT (P=0.19), and the PRT test scores (P=0.48). Conclusion: Our findings suggest that short-term oral vitamin A supplementation improves the quality, but not quantity, of tears in patients with dry eye. Future studies should involve larger patient samples and longer periods of vitamin A supplementation.

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Section: Discussionmentioning

confidence: 99%

<p>Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye</p>

Alanazi¹,

El‐Hiti²,

Al-Baloud³

et al. 2019

OPTH

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“…20,21 Nevertheless, the inflammatory process in uveitis that involves cytokine alteration such as IL-6 and TNF may influence the corneal condition, 17 because the use of cyclosporine that suppresses interleukin activity can relieve some categories of keratopathies. 22 Moreover, the corneal endothelial cells were damaged with an altered central corneal thickness in patients with uveitis, [14][15][16]23 whereas inflammatory cell infiltration into the corneal stoma was also observed during the onset of anterior uveitis. 24 On the other hand, the same inflammatory mediators and immune cells increased with uveitis and keratopathies, 17,25,26 indicating that a general immune reaction and inflammatory response could cause both uveitis and several types of keratopathies.…”

Section: Discussionmentioning

confidence: 99%

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Nien

Lee

Chao

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the effect of uveitis on the development of various keratopathies via the use of the National Health Insurance Research Database (NHIRD) in Taiwan. METHODS. Approximately 1 million patients were randomly sampled from the registry of the NHIRD. Patients diagnosed with uveitis by ophthalmologists were enrolled in the study group after exclusion. Each individual in the study group was age and sex matched to four nonuveitis individuals who serve as the control group. In addition to keratopathy, other possible risk factors and medications were included in the multivariate model, and the effects of different subtypes of uveitis for developing keratopathies were also analyzed. RESULTS. A total of 4773 uveitis patients (2662 male and 2111 female) and 19,092 non-uveitis patients (10,648 male and 8444 female) were enrolled. There were 406 events of keratopathy in the study group, and another 764 events occurred in the control group. A higher incidence rate was found in the study group after adjustment (adjusted hazard ratio [aHR]: 1.772), with a greater cumulative probability (P < 0.0001). For the subgroup analysis, anterior uveitis (aHR ¼ 1.765) and panuveitis (aHR ¼ 3.386) increased the risk of developing keratopathies. Moreover, male sex was associated with a higher aHR than female sex for developing keratopathies in the study group. CONCLUSIONS. The presence of uveitis significantly elevates the risk for developing keratopathy.

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“…[8]. Положительный клинический эффект был получен при исполь-зовании ЦиА с большей концентрацией: 0,5, 1 и 2 % [1,14]. Однако высокая концентрация ЦиА и масляная основа препарата создавали предпо-сылки для развития ряда побочных эффектов: задержки эпителизации роговицы, эпителиопа-тии, аллергической и токсической реакции.…”

Section: A New Methods For Treatment Severe Forms Of Dry Keratoconjuncunclassified

A new method for treatment severe forms of dry keratoconjunctivitis (preliminary results)

Safonova¹,

Gladkova²,

Новиков³

et al. 2017

Ophthalmology Reports

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The aim is to improve the treatment method of severe keratoconjunctivitis sicca (KCS) forms using designed soft contact lenses (SCL). Material and methods. An original SCL of silicone hydrogel material with individual optical power, consisting of a non-through depot filled with 0.05% Cyclosporin A (CyA) was designed. The therapeutic CyA saturated SCL was used in 5 patients (1 male and 4 females; 7 eyes) aged from 34 to 66 years, with severe KCS, who were constantly wearing them for 7-14 days. Patients additionally instilled hyaluronic acid containing non-preserved artificial tears up to 6 times a day. Standard ophthalmic examination, Schirmer test, tear break-up-time test, tests using vital dyes (assessed using the Oxford scale), tear osmolarity measurements (TearLab System, USA), tear pH measurement by a highly sensitive litmus test, conjunctival culture, measurement of the interpalpebral fissure width were carried out, the ocular surface disease index (OSDI) was determined. Treatment results were assessed in 1 week, 1 month, and 3 months since the SCL wear start. Results. The use of therapeutic CyA saturated SCL allows to achieve complete corneal epithelization, and helps to reduce inflammation within the time from 1 week up to 1 month, significantly reducing the treatment timeframe of severe forms of KSC in comparison to standard therapy. Conclusion. The developed treatment method for severe forms of the KCS consists in using specifically designed therapeutic SCL which provides an even CyA 0.05% release on the ocular surface, while instilling non-preserved artificial tears. Preliminary results show a high efficacy of this method in terms of reducing corneal epithelization time up to 1 week-1 month and resolving inflammation on the ocular surface. (For citation: Safonova TN, Gladkov OV, Novikov IA, Boev VI. A new method for treatment severe forms of dry keratoconjunctivitis (preliminary results). Ophthalmology Journal. 2017;10(3):53-59. doi: 10.17816/OV10353-59).

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Topical Cyclosporine A 1% for the Treatment of Chronic Ocular Surface Inflammation

Abstract: Topical CsA 1% helps to control inflammation and spares CS use in patients with chronic OSI.

Cited by 17 publications

References 28 publications

<p>Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye</p>

<p>Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye</p>

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

A new method for treatment severe forms of dry keratoconjunctivitis (preliminary results)

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