Topical Gel Based Nanoparticles for the Controlled Release of Oleanolic Acid: Design and In Vivo Characterization of a Cubic Liquid Crystalline Anti-Inflammatory Drug
Abstract:Background: Oleanolic acid (OA) has multiple pharmaceutical applications, but low permeability of the molecule limits its widespread use. Methods:A cubic liquid crystalline nanoparticle (LCNP)-based gel was prepared as a potential topical delivery system for OA. The LCNP-based gel was optimized using rheological, drug release kinetic, and ex vivo permeation studies.Results: The studies showed that the OA was trapped in the interior of the LCNP with a crystal form of Pn3m space. The optimized LCNP formulation p… Show more
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