Topical growth factor preparations for facial skin rejuvenation: A systematic review

Quinlan, Daniel J.; Ghanem, Ali; Hassan, Haidar

doi:10.1111/jocd.15644

Cited by 1 publication

(2 citation statements)

References 50 publications

(169 reference statements)

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“…19 FB-derived growth factors or secretome currently account for the largest number of published clinical studies on use of topical growth factors for skin rejuvenation. 20 Human foreskin FB and umbilical cord MSCs (UC-MSC) share similar surface markers, strong multilineage differentiation capacity and similarities in mRNA expression profile and metabolites. 21 There is increasing evidence that FB can also differentiate into other cell types including cells of adipogenic and osteogenic lineages.…”

Section: Fbs Secretome As a Source Of Rejuvenating Exosomesmentioning

confidence: 99%

“…Thus, dermal FB play a key role in maintaining skin structure and function. FB derived growth factors have been successfully used in skincare since 2001 with multiple clinical studies showing improvements in skin quality parameters and no reports of serious adverse events 20. The source of growth factors in these products is a conditioned medium of FB culture which has been shown to provide higher biological activity in human skin models than other sources of growth factors or secretome 26.…”

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confidence: 99%

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Fibroblast‐derived growth factors and exosomes as cosmeceuticals

Mehta,

Kadoya,

Maitra

et al. 2023

Dermatological Reviews

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IntroductionFibroblast (FB)‐derived growth factors have been successfully used in skincare to improve the appearance of aged and photodamaged skin for over 20 years. Conditioned media from FB culture, used as a source of growth factors in these early products, also contain extracellular vesicles including bioactive exosomes. Exosomes are tiny extracellular vesicles that have been isolated from the secretome of human‐derived mesenchymal stem cells (MSC), adipose‐derived stem cells, or fibroblasts for potential clinical application in wound healing, skin rejuvenation, skin disease, pigmentation, and hair growth.PurposeHere, we review the potential application of dermal FB‐derived growth factors and exosomes in maintaining the structure and function of healthy skin. Specifically, we discuss how to collect and characterize FB‐derived exosomes, formulation considerations for skincare products that may contain exosomes, and provide preliminary data to support its clinical use in improving skin quality.ResultsExosomes were successfully isolated from FB secretome and characterized for their content, markers, biological activity, and clinical effects. Condition of growth medium affected exosomes compositions and properties. Product containing 98 billion EVs /mL used twice a day for 12 weeks resulted in statistically significant improvement in all skin aging parameters tested including wrinkles, roughness, sagging and laxity.ConclusionOverall, active exosomes can be identified along with growth factors in the secretome of dermal fibroblasts and may provide an additional benefit for aging skin if its biological activity remains stable in the product formulation.

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Section: Fbs Secretome As a Source Of Rejuvenating Exosomesmentioning

confidence: 99%

mentioning

confidence: 99%