Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans

Sivapirabu, Geetha; Yiasemides, Eleni; Halliday, Gary M.; Park, J.; Damian, Diona L.

doi:10.1111/j.1365-2133.2009.09244.x

Cited by 84 publications

(83 citation statements)

References 38 publications

(52 reference statements)

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“…Since niacinamide is essentially involved in the cellular energy metabolism, the regulation of DNA synthesis, as well as in transcription processes, various biological effects can be observed after in vitro and in vivo substitution [15,16,17,18]. These effects are particularly striking in quantities that exceed physiological concentration, as they can be reached by epicutaneous application of niacinamide-containing galenic systems [15].…”

Section: Biological Effects With Dermatological Relevancementioning

confidence: 99%

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Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Wohlrab¹,

Kreft²

2014

Skin Pharmacol Physiol

107

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Niacinamide, an amide of vitamin B₃ (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic and lightening effects depending on its concentration. Within a complex metabolic system niacinamide controls the NFκB-mediated transcription of signalling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically founded evaluation, it can be stated that the use of niacinamide in galenic preparations for epicutaneous application offers most interesting prospects.

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Section: Biological Effects With Dermatological Relevancementioning

confidence: 99%

“…These effects are particularly striking in quantities that exceed physiological concentration, as they can be reached by epicutaneous application of niacinamide-containing galenic systems [15]. There are indications that these effects can be relevant for dermatological practice (fig.…”

Section: Biological Effects With Dermatological Relevancementioning

confidence: 99%

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Wohlrab¹,

Kreft²

2014

Skin Pharmacol Physiol

107

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“…Nicotinamide enhances DNA repair in UVirradiated human HaCaT keratinocytes and ex vivo human skin (7), likely by preventing UV-induced ATP depletion (8). The immunosuppressive effects of UV radiation are also reduced by nicotinamide (9,10). In phase 2 clinical trials, it reduced premalignant actinic keratoses and significantly reduced new non-melanoma skin cancers, although this was not a primary endpoint (11).…”

Section: Introductionmentioning

confidence: 99%

Nicotinamide enhances repair of ultraviolet radiation‐induced DNA damage in primary melanocytes

Thompson

Surjana

Halliday

et al. 2014

Experimental Dermatology

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Cutaneous melanoma is a significant cause of morbidity and mortality. Nicotinamide is a safe, widely available vitamin that reduces the immune suppressive effects of UV, enhances DNA repair in keratinocytes and has shown promise in the chemoprevention of non-melanoma skin cancer. Here, we report the effect of nicotinamide on DNA damage and repair in primary human melanocytes. Nicotinamide significantly enhanced the repair of oxidative DNA damage (8-oxo-7,8-dihydro-2 0 -deoxyguanosine) and cyclobutane pyrimidine dimers induced by UV exposure. It also enhanced the repair of 8-oxo-7,8-dihydro-2 0 -deoxyguanosine induced by the culture conditions in unirradiated melanocytes. A significant increase in the percentage of melanocytes undergoing unscheduled but not scheduled DNA synthesis was observed, confirming that nicotinamide enhances DNA repair in human melanocytes. In summary, nicotinamide, by enhancing DNA repair in melanocytes, is a potential agent for the chemoprevention of cutaneous melanoma.Abbreviations: 8oxoG, 8-oxo-7,8-dihydro-2 0 -deoxyguanosine; ATP, adenosine triphosphate; BrdU, bromodeoxyuridine; CPD, cyclobutane pyrimidine dimer; MC1R, melanocortin-1 receptor; NAD, nicotinamide adenine dinucleotide; NAM, nicotinamide; ROS, reactive oxygen species; UDS, unscheduled DNA synthesis.

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“…Sivapirabu et al [11] report that topical nicotinamide provides some protection against UV-induced immunesuppression.…”

Section: Vitaminsmentioning

confidence: 99%

Benefits of Anti-Aging Actives in Sunscreens

Lintner

2017

Cosmetics

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Sunscreens are functional, utilitarian, cosmetic products. The criteria of purchase are different from those for skin care and make-up. Companies are trying to add glamour and value to basic sunscreens by incorporating "active" ingredients (other than UV filters) into these formulas and by communicating about the additional benefits, be they anti-aging, moisturizing, firming, anti-wrinkle, etc. While some of these ideas of additional ingredients make sense as supplementary skin protection, some others do not afford much benefit in view of the infrequent application and short period of usage. The present article reviews some of these ideas and presents a few active ingredients that might be of value in such a context, even if substantiation of such additional claims in sunscreens is often lacking.

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Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans

Abstract: Longwave UVA, which is poorly filtered by most sunscreens, was highly immune suppressive even at doses equivalent to 20 min of sun exposure. Nicotinamide, which protected against both UVB and UVA, is a promising agent for skin cancer prevention.

Cited by 84 publications

References 38 publications

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Nicotinamide enhances repair of ultraviolet radiation‐induced DNA damage in primary melanocytes

Benefits of Anti-Aging Actives in Sunscreens

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