Topical Phenol as a Conservative Treatment for Periungual Pyogenic Granuloma

Iglesias, Marta Elena Losa; Becerro-de-Bengoa-Vallejo, Ricardo

doi:10.1111/j.1524-4725.2010.01528.x

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…This option shows beneficial effects, such as strong antiseptic properties, production of necrosis during protein coagulation, and reduction of pain due to nerve fiber demyelination in the nail unit [11,12]. Nevertheless, chemical matricectomy with 88% phenol solution may produce a delay in the healing time (between 21 and 42 days) related to tissue destruction, excessive drainage, and an adverse reaction to the phenol solution [10,[13][14][15]. On the other hand, incisional surgical options are indicated for advanced stages with hypertrophy of the nail folds.…”

Section: Introductionmentioning

confidence: 99%

“…First, a wedge resection of soft tissue is carried out, eliminating the germinal cells of the matrix and of the nail bed, and later a curettage is done of the surgical zone. The chemical matricectomy with phenol has the highest effectiveness rate [16], but it has a long healing time [7][8][9][10][11][12][13][14][15]. Aesthetic reconstruction has as advantages, a shorter healing time with respect to chemical matricectomy with phenol with a similar effectiveness [1].…”

Section: Introductionmentioning

confidence: 99%

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The Treatment of Ingrown Nail: Chemical Matricectomy With Phenol Versus Aesthetic Reconstruction. A Single Blinded Randomized Clinical Trial

Muriel-Sánchez

Becerro-de-Bengoa-Vallejo

Montaño‐Jiménez

et al. 2020

JCM

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Background: In onychocryptosis surgery, incisional and non-incisional matricectomy is indicated according to the stage. The chemical matricectomy with 88% phenol solution is the gold standard and a wedge resection is indicated for more advanced stages. The aesthetic reconstruction has the advantages of the incisional procedure without eponychium incisions and an effectiveness similar to the chemical matricectomy with phenol. Objective: To compare the recurrence and the healing time between the chemical matricectomy with phenol and the aesthetic reconstruction. Methods: A comparative, prospective, parallel, randomized, and one-blinded clinical trial was registered with the European Clinical Trials Database (EudraCT) with identification number 2019-001294-80. Thrity-four patients (56 feet) with 112 onychocryptosis were randomized in two groups. Thirty-six were treated with chemical matricectomy with phenol and 76 with aesthetic reconstruction. Each patient was blind to the surgical procedure assigned by the investigator. The primary outcome measurements were healing time and recurrence. The secondary outcome measurements were post-surgical bleeding, pain, inflammation, and infection rate. Results: The aesthetic reconstruction procedure presents a shorter healing time (8.2 ± 1.4 days vs. 21.3 ± 3.1 days; p < 0.001) with a similar recurrence rate (p = 0.98). Post-operatory bleeding, pain, inflammation, and the infection rate did not show significant differences (p > 0.05). Conclusions: The aesthetic reconstruction presents a shorter healing time, favoring the patients’ recuperation, with a recurrence similar to the chemical matricectomy with 88% phenol solution.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Treatment of Ingrown Nail: Chemical Matricectomy With Phenol Versus Aesthetic Reconstruction. A Single Blinded Randomized Clinical Trial

Muriel-Sánchez

Becerro-de-Bengoa-Vallejo

Montaño‐Jiménez

et al. 2020

JCM

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“…Losa Iglesias et al . suggest a regimen that includes three consecutive applications of a 98% phenol solution for 1 minute weekly, over a period of 2 to 14 weeks, depending on size and clinical response, while Panariello et al . suggest using a solution of 8% phenol…”

Section: Resultsmentioning

confidence: 99%

“…Pyogenic granuloma on the leg of an 11-year-old patient AFTER treatment with 5% topical imiquimod cream, showing partial regression suggest a regimen that includes three consecutive applications of a 98% phenol solution for 1 minute weekly, over a period of 2 to 14 weeks, depending on size and clinical response,22 while Panariello et al suggest using a solution of 8% phenol.…”

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confidence: 99%

Therapeutic approaches to pyogenic granuloma: an updated review

Plachouri

Georgiou

2018

Int J Dermatology

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Pyogenic granuloma is a benign vascular proliferation of the skin and mucous membranes, whose pathogenesis is not fully understood. Despite its benign nature, it can have a significant negative impact on patients’ quality of life, and therefore appropriate therapy is needed. Over the years, a lot of therapeutic modalities have been used in order to successfully treat this condition. This paper is an updated systematic overview of all the reported successful treatments described in the literature and was conducted according to the PRISMA guidelines for systematic reviews. Articles derived from the databases PubMed, EMBASE, and SCOPUS, published between 1981 and 2018, were analyzed for this study. In the literature, there are several studies, case series, and case reports that demonstrate encouraging results with the use of various methods, such as surgical intervention or laser treatment, but also with more conservative approaches, including the application of topical and systemic agents. The selection of the appropriate treatment should be made individually, depending on severity of the disease and patient characteristics. Both research efforts as well as clinical reporting are necessary in order to provide more insight on the management of these vascular tumors. This paper aims to provide a summarized update on the reported therapies and to raise awareness for the need to conduct larger systematic studies in order to adequately evaluate and compare the effectiveness of the presented therapeutic strategies.

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“…18 Weekly topical phenol has also been reported as a therapy for periungual PG, with decreased size occurring within 1 week of topical application and complete resolution by 14 weeks. 21 Our preference is to use silver nitrate for small lesions in the office and surgically excise large lesions or those with atypical features worrisome for another type of tumor.…”

Section: Pyogenic Granulomamentioning

confidence: 99%