Topical phenytoin solution for treating pressure ulcers: a prospective, randomized, double-blind clinical trial

Subbanna, Prasanna Kumar T; Shanti, F X Margaret; George, Jacob; Tharion, George; Durai, S.; Chandy, Sara; Mathew, Binu; Suresh, R.

doi:10.1038/sj.sc.3102029

Cited by 23 publications

(15 citation statements)

References 10 publications

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“…It is noteworthy that studies of moderate to strong evidence pointed to the analgesic effects of this drug for wounds (10) , and their authors mentioned the use of phenytoin as a secure application (10,12,15) , important factors when one is concerned about systemic absorption that application of topical phenytoin may trigger.…”

Section: Discussionmentioning

confidence: 99%

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Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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RESUmoA fenitoína é um anticonvulsivante que vem sendo empregado na cicatrização de ferida. Os objetivos desta pesquisa foram: descrever como a produção científica apresenta o uso da fenitoína como agente cicatrizante e discutir sua aplicabilidade em feridas. Foi realizada, para tanto, revisão integrativa da literatura e análise pela hierarquia das práticas baseadas em evidências. Assim, analisaram-se 18 artigos que testaram a intervenção em feridas como úlceras de perna, por hanseníase, pé diabético, úlceras por pressão, tróficas, ferimentos de guerra, queimaduras, preparo da área receptora de enxerto, radiodermites e pós-extração de nevos melanocíticos. Uso sistê-mico da fenitoína no tratamento de fístulas e a hipótese do uso tópico no tratamento do vitiligo foram achados. Conclui-se que a fenitoína tópica é uma evidência científica. No entanto necessita-se de pesquisas robustas que sustentem o uso protocolar da fenitoína como mais uma opção de agente cicatrizante na prática clínica. Scientific production on the applicability of phenytoin in wound healing * CritiCal review AbStRActPhenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use of phenytoin as a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed.Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use of phenytoin in the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use of phenytoin is scientifically evidenced. However robust research is needed that supports a protocol for the use of phenytoin as another option of a healing agent in clinical practice. dEScRiPtoRS Phenytoin Wound healing Evidence-based nursing Review RESUmEnLa fenitoína es un anticonvulsivo que se utiliza en la cicatrización de heridas. Los objetivos de esta investigación fueron: describir cómo la producción científica presenta el uso de la fenitoína como agente cicatrizante y discutir su aplicabilidad en las heridas. Se realizó una revisión integradora de la literatura y el análisis por la jerarquía de las prácticas basadas en las evidencias. Se analizaron 18 artículos que probaron la intervención en heridas como úlceras en la pierna por hanseniasis, pie diabético, úlceras por presión, tróficas, heridas de guerra, quemadura, preparación de la zona a injertar, radiodermitis y post extracción de nevos melanocíticos. Se encontró el uso sistémico de la fenitoína en el tratamiento de fístulas y la hipótesis del uso tópico en el tratamiento del vitíligo. Se concluye que la fenitoína tópica es una evidencia científica. Sin embargo, se necesita de investigaciones sólidas que sustenten el uso protocola...

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Section: Discussionmentioning

confidence: 99%

“…Again it is important to consider that this drug was considered safe, inexpensive and effective in wound healing by several researchers considered in this integrative review (4,(8)(9)(10)(11)(12)(16)(17)19,21) .…”

Section: Rev Esc Enfermmentioning

confidence: 99%

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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“…Multiple methods of wound evaluation can be used to track an ulcer over time, including area, 27 volume, 28 linear growth of wound edges, 29 and the Pressure Ulcer Scale for Healing (PUSH) score. 30 Each of these methodologies has strengths and limitations that have led to varied use across clinical settings.…”

Section: Objective Wound Evaluationmentioning

confidence: 99%

Standardization of Wound Photography Using the Wound Electronic Medical Record

Rennert

Golinko

Kaplan

et al. 2009

Advances in Skin &Amp; Wound Care

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“…10 While most of the studies regarding phenytoin and wound healing showed phenytoin efficacy there are studies which reported no important effect. [11][12][13] Several methods have been used to study healing promotion, but few studies investigated these modalities in comparison to each other. [14][15][16][17][18] In this study we evaluated the effect of low-level laser in wound healing and compared it with phenytoin.…”

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confidence: 99%