Topical progress in medicinal applications of self‐assembled organoplatinum complexes using diverse Pt(II)‐ and N‐based tectons

Kumar, Saurabh; Jana, Achintya; Bhowmick, Sourav; Das, Neeladri

doi:10.1002/aoc.6722

Cited by 4 publications

(1 citation statement)

References 113 publications

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“…Coordination-based spherical assemblies (CBSAs) have recently gained attention in the medicinal context. [41][42][43][44] CBSAs are well-defined nanosized materials that are constructed by coordination of multi-topic ligands to transition metals. [45][46][47][48] 53 Whereas some studies have suggested the application of CBSAs as genotoxic agents, to the best of our knowledge their potential as gene delivery agents has never been investigated.…”

Section: The Bigger Picturementioning

confidence: 99%

The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

Bobylev

Zeng

Weijgertse

et al. 2023

Chem

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Section: The Bigger Picturementioning

confidence: 99%

The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

Bobylev

Zeng

Weijgertse

et al. 2023

Chem

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Synthesis and Luminescent Properties of Zwitterionic Platinum Bis‐Phosphine Complexes Based on a Pendant Closo‐Monocarborane Cluster

Jin,

Shen,

Qiu

et al. 2024

Applied Organom Chemis

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The synthesis, structures and photophysical properties of a series of zwitterionic platinum complexes are reported. These cyclometalated complexes have the general structure Pt(C^N)(P^P), where C^N is a cyclometalating ligand with a pendant monocarborane cluster and P^P is a bis‐phosphine ligand (dppe or dppb). Their solid‐state structures have been characterized by x‐ray diffraction, and no Pt–Pt interactions are observed. All complexes are emissive at room temperature in solid states with quantum yields of 0.06–0.58 in PMMA films. The emission energy of these complexes is governed by the nature of the C^N cyclometalated ligands, allowing the emission to be tuned from blue to green. In particular, the introduction of an anionic carborane unit provokes a more than twofold improvement in the photoluminescence quantum yield of [Pt(CB11‐ppy)(dppe)] (3b) compared to the parent cationic complex [Pt(ppy)(dppe)]+. In addition, density functional theory (DFT) calculations were performed on the ground states and first triplet excited states of 1a, 2a, and 3a for interpretation of the observed photophysical properties.

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Modulating the Anticancer Activity of Square‐Planar Platinum (II) Complex by Its Chelated Diphosphine

Li,

Hou,

Xiao

et al. 2024

Applied Organom Chemis

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This work reports the preparations and anticancer activities of a set of platinum (II) complexes. Two types of bidentate ligands, azadiphosphine (PNP) and diphosphine (PP), were applied to afford different kinds of platinum centers, the homoleptic complexes, [Pt (PNP)2]2+ (1 and 2) and [Pt (PP)2]2+ (4), and the hybrid complex, [Pt (PNP)(PP)]2+ (3). All these complexes are characterized by various analytical techniques, and their structures were validated using single‐crystal X‐ray diffraction analysis. Notably, the stability of the complexes 1–4 is differentiated both in phosphate‐buffered saline (PBS) and in the culture media (RPMI‐1640), relative to the type of coordinated diphosphine ligands, specifically, the more PNP ligands, the less stability. The bite angles of P‐Pt‐P bonds in 1–4 would be reliant on their stability, so that complexes 1 and 2 with small bite angles tend to be labile. A mechanistic understanding on the decomposition of 2 is proposed with the aid of mass analysis. As a result, their anticancer activities should be also associated with their stability so that the chelated ligands, with more PNP ligands, lead to more cytotoxicity. Mechanistically, the poisonous platinum (II) derivatives of complex 2 should interact with the nucleus DNA, whereas the intact complex 4 is not traceable, confirming from a γ‐H2AX‐related immunofluorescence staining kit. Additionally, complex 2 exhibits severe toxicity toward several cancer cells as well as a normal cell. Furthermore, complex 2 has inhibited the formation and viability of three‐dimensional T24 mammospheres, reminding it of a promising candidate for anticancer treatments. Overall, the present work provides a way for the systematic investigation to elucidate how a bidentate diphosphine ligand modulates the stability and the anticancer activities of the corresponding square‐planner platinum (II) complex.

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Topical progress in medicinal applications of self‐assembled organoplatinum complexes using diverse Pt(II)‐ and N‐based tectons

Cited by 4 publications

References 113 publications

The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

The application of M12L24 nanocages as cell-specific siRNA delivery agents in vitro

Synthesis and Luminescent Properties of Zwitterionic Platinum Bis‐Phosphine Complexes Based on a Pendant Closo‐Monocarborane Cluster

Modulating the Anticancer Activity of Square‐Planar Platinum (II) Complex by Its Chelated Diphosphine

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