Topical therapy for canine pyoderma: what is new?

Abstract

Antimicrobial-resistant cutaneous infections are increasing in veterinary medicine. The use of systemic antibiotics should be limited to severe cases of pyoderma to decrease the microbial pressure and selection for multidrug-resistant bacteria. Topical antimicrobials with a low-resistance profile, such as chlorhexidine, benzoyl peroxide, and ethyl lactate have been used for decades in veterinary dermatology. However, new alternatives have been explored in the past decade. The goal of this review is to summarize the current knowledge on the antibacterial efficacy and clinical use, when reported, of “classic” and new treatment options for topically treating canine pyoderma. This review is intended to fill the gap from previous systematic reviews published in veterinary dermatology a decade ago. The studies reported in this review emphasize the need and desire for alternatives to the classic topical antimicrobials used in veterinary medicine to significantly reduce the use of systemic antibiotics in the spirit of appropriate antimicrobial stewardship.

Methicillin-resistant Staphylococci in canine pyoderma in Thailand

“…The MDR-S antibiogram showed that some isolates were susceptible to amikacin, which has serious side effects, including nephrotoxicity, and requires close monitoring for kidney function [ 47 ]. Therefore, topical therapy is the only option for skin infection with MDR-SP, MRSP, and other MDR MRs [ 16 , 48 , 49 ]. Notably, among the tier 1 antibiotics for typical SP, the β-lactam antibiotics had a very high susceptibility, greater than but potentiated sulphonamides was at 70%.…”

“…The MDR-S antibiogram showed that some isolates were susceptible to amikacin, which has serious side effects, including nephrotoxicity, and requires close monitoring for kidney function [47]. Therefore, topical therapy is the only option for skin infection with MDR-SP, MRSP, and other MDR MRs [16,48,49].…”

Exploring fluorescent light energy as management option for canine superficial bacterial folliculitis

“…SBF, as part of bacterial pyoderma, is more common in dogs than other mammalian species and this fact has stimulated the research on this topic. Treating SBF usually requires a multimodal approach (19). Proper identification and treatment of the primary cause is mandatory since if only symptomatic medications are given, incomplete healing or recurrence is likely to occur (19).…”

“…Treating SBF usually requires a multimodal approach (19). Proper identification and treatment of the primary cause is mandatory since if only symptomatic medications are given, incomplete healing or recurrence is likely to occur (19). Systemic antimicrobial drugs (AMD) are routinely used for the treatment of SBF (20).…”

Diving into dermatology

“…As our awareness of resistance as a result of antibiotic pressure increases, it is good practice to treat superficial bacterial infections topically as much as possible rather than systemically. Dr. Santoro 16 provides us with an update on topical therapy for canine pyoderma and how we can select the best option for our patients.…”