Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel β-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation

Sakisaka, Hideto; Takedatsu, Hidetoshi; Mitsuyama, Keiichi; Mochizuki, Seibu; Sakurai, Kazuo; Sakisaka, Shotaro; Hirai, Fumihito

doi:10.3390/ijms21020683

Cited by 17 publications

(6 citation statements)

References 40 publications

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“…SPG-ASO is an enema containing ASO against TNF-α complexed with the polysaccharide schizophyllan, which is a β-(1–3) glucan [ 117 ]. The complexion resulted in a stable ASO formulation that was targeted to cells expressing the Dectin-1 receptor.…”

Section: Preclinical Studies On Local Tnf-α Inhibitionmentioning

confidence: 99%

Review: Local Tumor Necrosis Factor-α Inhibition in Inflammatory Bowel Disease

et al. 2020

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Crohn’s disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) characterized by intestinal inflammation. Increased intestinal levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) are associated with disease activity and severity. Anti-TNF-α therapy is administered systemically and efficacious in the treatment of IBD. However, systemic exposure is associated with adverse events that may impede therapeutic treatment. Clinical studies show that the efficacy correlates with immunological effects localized in the gastrointestinal tract (GIT) as opposed to systemic effects. These data suggest that site-specific TNF-α inhibition in IBD may be efficacious with fewer expected side effects related to systemic exposure. We therefore reviewed the available literature that investigated the efficacy or feasibility of local TNF-α inhibition in IBD. A literature search was performed on PubMed with given search terms and strategy. Of 8739 hits, 48 citations were included in this review. These studies ranged from animal studies to randomized placebo-controlled clinical trials. In these studies, local anti-TNF-α therapy was achieved with antibodies, antisense oligonucleotides (ASO), small interfering RNA (siRNA), microRNA (miRNA) and genetically modified organisms. This narrative review summarizes and discusses these approaches in view of the clinical relevance of local TNF-α inhibition in IBD.

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Section: Preclinical Studies On Local Tnf-α Inhibitionmentioning

confidence: 99%

Review: Local Tumor Necrosis Factor-α Inhibition in Inflammatory Bowel Disease

et al. 2020

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“…Tumor necrosis factor-alpha (TNFα) is a critical cytokine involved in various autoimmune diseases as it plays a widespread role in the establishment and maintenance of inflammation. 49 TNFα plays a pathogenic role in many inflammatory ailments by acting as a vital controller of inflammatory pathways. 50 We selected the well-known inhibitor of TNFα namely 6,7-dimethyl-3-((methyl -(2-(methyl-((1-(3-(trifluoromethyl) phenyl)indol-3-yl) methyl) amino) ethyl) amino) methyl)chromen-4-one (AC1NS1JP) as a positive control.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Mondal

Quispe

Sarkar

et al. 2021

Natural Product Communications

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The objective of our present study is to scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of 100, 200, and 400 mg/kg body weight. Twenty chemical compounds, which were isolated from the leaves essential oil of E. camaldulensis, were docked using AutodockVina against cyclooxygenase 2, tumor necrosis factor-α, and interleukin-1β convertase to elucidate the analgesic and anti-inflammatory activity. The essential oil of E. camaldulensis exhibited noteworthy analgesic activities in the writhing test. In the tail immersion and hot-plate test, the essential oil significantly extended the latency period. The number of licks in the formalin-induced paw licking test was markedly reduced following essential oil administration. In addition, E. camaldulensis essential oil revealed notable anti-inflammatory responses in carrageenan-induced paw edema, xylene induced ear edema and cotton pellet induced granuloma methods. Among 20 compounds, 5 ( cis-sabinol, globulol, α-eudesmol, β-eudesmol, and γ-eudesmol) showed better binding for cyclooxygenase-2 while β-eudesmol exhibited higher affinity for TNFα than that of TNF-alpha-IN-1 and standard drug. In the case of interleukin 1β convertase, maximum affinity was shown by α-eudesmol than the synthetic drug belnacasan. Chemical components of the essential oil interacted with diverse amino acid residues which were similar to the natural substrate and standard drugs. In conclusion, E. camaldulensis essential oil can be an effective source of analgesic and anti-inflammatory treatment and additional modification and docking studies will be required to justify the efficiency of globulol, α-eudesmol, β-eudesmol, and γ-eudesmol.

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“…of TNF-α at the site of inflammation thereby increased therapeutic efficacy. 130 Both, the time to loss of crust and time to crusting of lesions were shorter in subjects treated with nanoformulation than with the commercial cream. 133 In a study, evaluated ammonium glycyrrhizinate loaded ethosomal suspension (size 100-350 nm) for their potential topical application in human volunteers applied for 48 hr.…”

Section: Latest Nanotechniques Under Development For Topical Deliverymentioning

confidence: 92%

Emerging trends in nanomedicine for topical delivery in skin disorders: Current and translational approaches

Pandey

Satija

Wadhwa

et al. 2020

Dermatologic Therapy

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A drug can be administered topically in a localized manner anywhere in the body through various routes including ophthalmic, rectal, vaginal, and skin. 1 Being the largest organ of the human body, the skin performs various functions including protection from the external environment, it serves as the first line of defense against the entry of microorganisms and chemicals, and provides a barrier to the loss of salts and fluids which helps in regulating body temperature. 2 It performs numerous indispensable capacities, including insurance against outside physical, substance and biologic attackers, just as avoidance of overabundance water loss from the body and a role in thermoregulation. The skin is persistent, with the mucous layers coating the body's surface. The skin is principally mesodermal in its embryonic induction. Specific skin cells and structures are shaped from 3 to 6 months of gestation. 3

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Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel β-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation

Cited by 17 publications

References 40 publications

Review: Local Tumor Necrosis Factor-α Inhibition in Inflammatory Bowel Disease

Review: Local Tumor Necrosis Factor-α Inhibition in Inflammatory Bowel Disease

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies

Emerging trends in nanomedicine for topical delivery in skin disorders: Current and translational approaches

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