Topical Tranexamic Acid in Revision Total Knee Arthroplasty Reduces Transfusion Rates and May Be Associated With Earlier Recovery

Tranexamic Acid Is Associated With Reduced Periprosthetic Joint Infection After Primary Total Joint Arthroplasty

“…The association between preoperative anemia and SSI or PJI has been demonstrated in numerous prior studies [13e16,21e24]. Patients with preoperative anemia have higher likelihood of needing A recent study demonstrated additional benefits to TXA when administered to patients undergoing TKA [31]. Patients receiving TXA had less hidden blood loss, a lower ratio of postoperative knee swelling, less postoperative knee pain, lower levels of inflammatory biomarkers, better early knee function, and better satisfaction than those treated with tourniquet alone [32].…”

Is tranexamic acid effective and safe for patients undergoing revision total hip and knee arthroplasty: a meta-analysisIs

“…Eleven trials [13][14][15][20][21][22][23][24][25][26][27] were used in the meta-analysis of the transfusion requirements ( Figure 2.1). Significant heterogeneity was observed, and a random-effects model was used (I 2 = 73%, P < 0.0001).…”

“…Of the 12 studies [13][14][15][20][21][22][23][24][25][26][27][28], 5 trials with 1022 patients [14,21,22,24,26] compared preoperative and postoperative Hb levels in patients undergoing revision TJA with or without TXA (Figure 2. 2).…”

“…Seven studies [15,21,23,[25][26][27][28] reported the postoperative incidence rates of deep vein thrombosis and PE (Figure 2.5). No significant heterogeneity was observed, and a fixed-effects model was used (I 2 = 0%, P = 0.78).…”

“…Four studies [21,24,25,27] that included 802 subjects described other non-thromboembolic complications (Figure 2.6). Overall, 9 patients developed postoperative infections, 6 had recurrent dislocation, and 4 had periprosthetic fractures.…”