Topically applied rhGM-CSF for the wound healing: A systematic review

Hu, Xiaofan; Sun, Hongjuan; Han, Chunmao; Wang, Xingang; Wang, Yu

doi:10.1016/j.burns.2010.08.016

Cited by 42 publications

(46 citation statements)

References 59 publications

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“…There are many points at which the normal wound-healing process can be disturbed. [4,5] Two important pathological manifestations in wounds are fibrotic wounds, and keloid scar formation and ulcers. While in fibrotic wounds excess deposition of the matrix and lack of remodeling lead to hypertrophy, in keloid scar formation and ulcers, the wound is stuck in a state of chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Wound healing and antioxidant properties: do they coexist in plants?

Süntar

Akkol

Nahar

et al. 2012

Free Radicals and Antioxidants

151

109

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Section: Introductionmentioning

confidence: 99%

Wound healing and antioxidant properties: do they coexist in plants?

Süntar

Akkol

Nahar

et al. 2012

Free Radicals and Antioxidants

151

109

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“…Five systematic reviews including eight meta-analyses [29,30,39,51,62] and five systematic reviews without a meta-analysis [72,73,77,89,103] (Table 2; Additional files 4 and 6) examined venous leg ulcer healing. Four of these had an AMSTAR score ≥8 [30,62,73,89].…”

Section: Resultsmentioning

confidence: 99%

“…Tissue engineered skin was more effective than dressings in one meta-analysis [51], topical granulocyte-macrophage colony stimulating factor was more effective than placebo in another meta-analysis [29], and oral pentoxifylline was more effective with (or without) compression than placebo in another meta-analysis (AMSTAR score ≥8) [30]. …”

Section: Resultsmentioning

confidence: 99%

Seeking effective interventions to treat complex wounds: an overview of systematic reviews

Tricco

Antony

Vafaei

et al. 2015

BMC Med

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BackgroundNumerous, often multi-faceted regimens are available for treating complex wounds, yet the evidence of these interventions is recondite across the literature. We aimed to identify effective interventions to treat complex wounds through an overview of systematic reviews.MethodsMEDLINE (OVID interface, 1946 until October 26, 2012), EMBASE (OVID interface, 1947 until October 26, 2012), and the Cochrane Database of Systematic Reviews (Issue 10 of 12, 2012) were searched on October 26, 2012. Systematic reviews that examined adults receiving care for their complex wounds were included. Two reviewers independently screened the literature, abstracted data, and assessed study quality using the Assessment of Multiple Systematic Reviews (AMSTAR) tool.ResultsOverall, 99 systematic reviews were included after screening 6,200 titles and abstracts and 422 full-texts; 54 were systematic reviews with a meta-analysis (including data on over 54,000 patients) and 45 were systematic reviews without a meta-analysis. Overall, 44% of included reviews were rated as being of high quality (AMSTAR score ≥8). Based on data from systematic reviews including a meta-analysis with an AMSTAR score ≥8, promising interventions for complex wounds were identified. These included bandages or stockings (multi-layer, high compression) and wound cleansing for venous leg ulcers; four-layer bandages for mixed arterial/venous leg ulcers; biologics, ultrasound, and hydrogel dressings for diabetic leg/foot ulcers; hydrocolloid dressings, electrotherapy, air-fluidized beds, and alternate foam mattresses for pressure ulcers; and silver dressings and ultrasound for unspecified mixed complex wounds. For surgical wound infections, topical negative pressure and vacuum-assisted closure were promising interventions, but this was based on evidence from moderate to low quality systematic reviews.ConclusionsNumerous interventions can be utilized for patients with varying types of complex wounds, yet few treatments were consistently effective across all outcomes throughout the literature. Clinicians and patients can use our results to tailor effective treatment according to type of complex wound. Network meta-analysis will be of benefit to decision-makers, as it will permit multiple treatment comparisons and ranking of the effectiveness of all interventions.Please see related article: http://dx.doi.org/10.1186/s12916-015-0326-3Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-015-0288-5) contains supplementary material, which is available to authorized users.

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“…Human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a multifunctional growth factor and a mitogenic agent that has been demonstrated to be involved in a number of essential processes of wound healing (12,13). Recombinant hGM-CSF (rhGM-CSF) has been demonstrated to promote the healing of infected burn wounds, as well as prevent infections by modulating immune activity and improving immune competence (14).…”

Section: Introductionmentioning

confidence: 99%

“…The first use of locally-delivered rhGM-CSF in chronic wounds was reported in 1994 (15). Clinical studies and case reports have demonstrated that rhGM-CSF has a positive effect on chronic wounds with varying etiologies, including chronic venous ulcers, pressure ulcers, erythropathy-associated ulcers, neutrophil dysfunction-associated chronic ulcers, immunodeficiency-associated ulcers, leprosy ulcers and refractory wounds in patients with cancer (12). However, it has previously been demonstrated that rhGM-CSF does not have a significant effect on healthy wounds (16).…”

Section: Introductionmentioning

confidence: 99%

Combined application of alginate dressing and human granulocyte-macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers

Huang

Sun

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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The aim of the present study was to evaluate the clinical therapeutic effect of the combined application of alginate and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on the healing of refractory chronic skin ulcers. A single center, three arm, randomized study was performed at Jinan Central Hospital (Jinan, Shandong, China). A total of 60 patients with refractory chronic skin ulcers, which persisted for >1 month, were enrolled and randomly assigned into one of the following three groups: alginate dressing/rhGM-CSF group (group A), rhGM-CSF only group (group B) and conventional (vaseline dressing) group (group C). The wound area rate was measured, granulation and color were observed and pain was evaluated. The data were summarized and statistical analysis was performed. The results demonstrated that group A exhibited a significantly faster wound healing rate and lower pain score compared with the other groups (P<0.01). In conclusion, the combined application of alginate dressing and rhGM-CSF for the treatment of refractory chronic skin ulcers demonstrated significant advantages. It promoted the growth of granulation tissue, accelerated re-epithelialization and also effectively reduced wound pain, and thus improved the quality of life for the patient. This suggests that the combined application of alginate and rhGM-CSF may be an effective therapeutic strategy for the clinical treatment of refractory chronic skin ulcers.

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Topically applied rhGM-CSF for the wound healing: A systematic review

Cited by 42 publications

References 59 publications

Wound healing and antioxidant properties: do they coexist in plants?

Wound healing and antioxidant properties: do they coexist in plants?

Seeking effective interventions to treat complex wounds: an overview of systematic reviews

Combined application of alginate dressing and human granulocyte-macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers

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