Topically applied vitamin C increases the density of dermal papillae in aged human skin

Sauermann, Kirsten; Jaspers, Sören; Koop, Urte; Wenck, Horst

doi:10.1186/1471-5945-4-13

Cited by 85 publications

(69 citation statements)

References 23 publications

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“…Moreover, Triphala contains ascorbic acid, which acts as a cofactor for the synthesis of collagen as well as elastin fibers [38]. The decreased collagen content in the control group might be due to prolonged inflammatory phase where the degradation of collagen will be more than the synthesis.…”

Section: Discussionmentioning

confidence: 99%

Triphala Promotes Healing of Infected Full-Thickness Dermal Wound

Muthusamy

Shanmugam

Sripriya

et al. 2008

Journal of Surgical Research

143

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Section: Discussionmentioning

confidence: 99%

Triphala Promotes Healing of Infected Full-Thickness Dermal Wound

Muthusamy

Shanmugam

Sripriya

et al. 2008

Journal of Surgical Research

143

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“…With acute sun exposure, genes with reparative, protective or apoptotic functions as well as stress communication genes are rapidly activated [19,57,58]. Ageing strikingly increases the expression of related genes when exposed to UV [59].…”

Section: Exposure To Uv Light (Photoageing)mentioning

confidence: 99%

Intrinsic and extrinsic factors in skin ageing: a review

Farage

Miller

Elsner

et al. 2008

Intern J of Cosmetic Sci

726

528

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SynopsisAs the proportion of the ageing population in industrialized countries continues to increase, the dermatological concerns of the aged grow in medical importance. Intrinsic structural changes occur as a natural consequence of ageing and are genetically determined. The rate of ageing is significantly different among different populations, as well as among different anatomical sites even within a single individual. The intrinsic rate of skin ageing in any individual can also be dramatically influenced by personal and environmental factors, particularly the amount of exposure to ultraviolet light. Photodamage, which considerably accelerates the visible ageing of skin, also greatly increases the risk of cutaneous neoplasms. As the population ages, dermatological focus must shift from ameliorating the cosmetic consequences of skin ageing to decreasing the genuine morbidity associated with problems of the ageing skin. A better understanding of both the intrinsic and extrinsic influences on the ageing of the skin, as well as distinguishing the retractable aspects of cutaneous ageing (primarily hormonal and lifestyle influences) from the irretractable (primarily intrinsic ageing), is crucial to this endeavour. Ré suméComme le pourcentage de la population vieillissante dans les pays industrialisés s'accroît, les préoccupations dermatologiques des personnes âgées augmentent en importance sur le plan médical. Les modifications structurelles intrinsè-ques sont une conséquence naturelle du vieillissement et sont génétiquement déterminées. La vitesse de vieillissement diffère significativement selon les différentes populations et selon les différ-ents sites anatomiques, même pour un seul individu. La vitesse intrinsèque du vieillissement de la peau pour un individu peut être aussi très influencée par les facteurs personnels et environnementaux, en particulier le taux d'exposition à la lumière ultra-violette. La photodégradation qui accélère considérablement le vieillissement visible de la peau augmente également beaucoup le risque de formation de néoplasme cutané. Au fur et à mesure que la population vieillit, il faut davantage se préoccuper de diminuer la morbidité réelle associée au vieillissement de la peau, plutôt que de palier à ses conséquences cosméti-ques. Il est donc crucial de s'efforcer à mieux comprendre les facteurs intrinsèques et extrinsè-ques qui agissent sur le vieillissement de la peau et aussi de faire la distinction entre les aspects réversibles du vieillissement cutané (facteurs essentiellement hormonaux et mode de vie) et les aspects irréversibles (principalement le vieillissement intrinsèque). The demographics of the U.S.A. are changing rapidly with respect to its elderly population; by 2030, one of every five Americans is expected to be over 65 [3]. It is predicted that life expectancy in the U.S.A. and other industrialized countries will continue to increase, hitting 100 years by about 2025 [4]. Women, with longer average life expectancies than men, can expect to spend more than one-third of th...

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“…Cells of the basal layer become less uniform in size, although average cellular size rises [42]. Keratinocytes change shape as skin ages, becoming shorter and fatter [40]; corneocytes become bigger due to decreased epidermal turnover [33,43]. Enzymatically active melanocytes .…”

Section: Changes In Composition Of Aging Skin Epidermismentioning

confidence: 99%