Topiramate reduces blood–brain barrier disruption and inhibits seizure activity in hyperthermia-induced seizures in rats with cortical dysplasia

Gürses, Candan; Orhan, Nurcan; Ahıshalı, Bülent; Yılmaz, Canan Uğur; Kemikler, Gönül; Elmas, İmdat; Çevik, Aydın; Küçük, Mutlu; Arıcan, Nadir; Kaya, Mehmet

doi:10.1016/j.brainres.2012.11.039

Cited by 16 publications

(17 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, abnormal microvessels in brain parenchyma and focal BBB leakage were reported in rats with cortical dysplasia . Although there is no confirmation supported with human studies, it has been shown that both hyperthermic and kindled seizures increased BBB permeability to certain tracers including Evans blue, horseradish peroxidase, and sodium fluorescein in a rat model of cortical dysplasia . In the genetic absence epilepsy model of WAG/Rij rats, Sahin et al.…”

Section: What We Can Learn From Animal Studiesmentioning

confidence: 99%

“…In their unpublished data, they observed a massive cortical tissue loss in WAG/Rij rats with cortical dysplasia, and suggested that the mechanism responsible for enhanced BBB permeability was increased caveolar vesicle–mediated transcellular transport. It has been suggested that enhancement of a transcellular pathway rather than paracellular opening of tight junctions accounts for the increase in BBB permeability in epileptic conditions as evidenced by ultrastructural observations . Given these many converging studies, a disrupted BBB, such as enhancement on imaging studies, could be a biomarker for the detection of epileptogenesis and translatable from animal studies to humans …”

Section: What We Can Learn From Animal Studiesmentioning

confidence: 99%

See 1 more Smart Citation

WONOEP appraisal: Development of epilepsy biomarkers—What we can learn from our patients?

et al. 2017

Self Cite

View full text Add to dashboard Cite

Summary Objective Current medications for patients with epilepsy work in only two out of three patients. For those medications that do work, they only suppress seizures. They treat the symptoms, but do not modify the underlying disease forcing patients to take these drugs with significant side effects often for the rest of their lives. A major limitation in our ability to advance new therapeutics that permanently prevent, reduce the frequency of, or cure epilepsy comes from a lack of understanding of the disease coupled with a lack of reliable biomarkers that can predict who has or who will get epilepsy. Methods The main goal of this report is to present a number of approaches on how we may be able to identify reliable biomarkers from observing patients with brain disorders that have a high probability of producing epilepsy. Results A given biomarker, or more likely a profile of biomarkers, will have both a quantity and a time course during epileptogenesis that can be used to predict who will get the disease, to confirm epilepsy as a diagnosis, to identify co-existing pathologies, and monitor the course of treatments. Significance Additional studies in patients and animal models could identify common and clinically valuable biomarkers as a means to successfully translate animal studies into new and effective clinical trials.

show abstract

Section: What We Can Learn From Animal Studiesmentioning

confidence: 99%

Section: What We Can Learn From Animal Studiesmentioning

confidence: 99%

WONOEP appraisal: Development of epilepsy biomarkers—What we can learn from our patients?

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…A third group of proteins involved in tight junction formation is made up by junction adhesion molecules which also contain intra-and extracellular domains [28][29][30]. Decreased expression of several tight junction proteins occurs in brain tissue of patients with epilepsy as well as in epileptic animals and is associated with increased BBB permeability [31][32][33][34][35][36].…”

Section: Blood-brain Barrier -Morphology and Transport Mechanismsmentioning

confidence: 99%

The blood–brain barrier—Gatekeeper to neuronal homeostasis: Clinical implications in the setting of stroke

Schoknecht

David

Heinemann

2015

Seminars in Cell & Developmental Biology

View full text Add to dashboard Cite

“…Notably, unless very high intensities or doses of respective stimuli are used, spontaneous seizures are not widespread. Instead, increased susceptibility to either experimentally-induced febrile seizures or pilocarpine administration is often observed (Battaglia et al, 2009;Cid et al, 2014;Fan et al, 2008;Gibbs et al, 2011;G€ urses et al, 2013;Setkowicz et al, 2003).…”

Section: Modeling Seizure Susceptibility and The "Second Hit Hypothesis"mentioning

confidence: 99%

Profiles of gene expression in the hippocampal formation of rats with experimentally‐induced brain dysplasia

Kielbinski

Setkowicz

Gzieło

et al. 2018

Developmental Neurobiology

View full text Add to dashboard Cite

Malformations of cortical development (MCD) are a common cause of intractable seizures in humans. Among these, focal cortical dysplasia (FCD) poses an outstanding challenge. There are several subtypes of FCD that show significant variation in pathology and clinical presentation. All types exhibit disturbed cortical cytoarchitecture and increased propensity for seizures. The etiology is likely heterogenous, with mutations, specifically in genes related to mammalian target of rapamycin (mTOR), identified in only a subset of cases. A more complex mechanism, in which underlying genetic background interacts with early, pre- or perinatal injury or stress, has been proposed. Here, we used a well-established animal model of developmental malformations similar to MCD, induced by prenatal gamma irradiation. Previously, a significant variation between times of treatment has been shown, resulting in distinct and lasting patterns of dysplasia and differentially altered seizure propensity. We set out to describe the molecular background of these patterns by performing microarray analyses of hippocampal samples obtained from adult rats previously irradiated at distinct time points during gestation: E13, E15, E17 or E19 as well as controls. The analysis was performed in three conditions: naïve, during latent phase after pilocarpine-induced status epilepticus and after 21 days of transauricular electric shocks. A set of 22 transcripts, some with known functions related to brain development, epilepsy and reaction to injury, was found to be altered between these groups across all treatments. We discuss the functional implication of these molecular differences, in an attempt to provide broader temporal and developmental context. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 718-735, 2018.

show abstract

Topiramate reduces blood–brain barrier disruption and inhibits seizure activity in hyperthermia-induced seizures in rats with cortical dysplasia

Cited by 16 publications

References 59 publications

WONOEP appraisal: Development of epilepsy biomarkers—What we can learn from our patients?

WONOEP appraisal: Development of epilepsy biomarkers—What we can learn from our patients?

The blood–brain barrier—Gatekeeper to neuronal homeostasis: Clinical implications in the setting of stroke

Profiles of gene expression in the hippocampal formation of rats with experimentally‐induced brain dysplasia

Contact Info

Product

Resources

About