Topographical, morphological and immunohistochemical characteristics of carcinoma in situ of the breast involving sclerosing adenosis. Two distinct topographical patterns and histological types of carcinoma in situ

Moritani, Suzuko; Ichihara, Shu; Hasegawa, Masaki; Endo, Tokiko; Oiwa, Mikinao; Shiraiwa, Misaki; Nishida, Chikako; Morita, Takako; Sato, Yasuyuki; Hayashi, Takako; Kato, Aya; Aoyama, Hideaki; Yoshikawa, Kunio

doi:10.1111/j.1365-2559.2011.03792.x

Cited by 21 publications

(17 citation statements)

References 28 publications

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“…According to the current study, about 36.4% cases of SA-BC were underestimated as benign adenosis or ADH at CNB. One possible explanation for these false-negative results might be that cancer within the extensive SA tends to be limited or occurs preferentially at the periphery of SA, peculiarly in those early stage tumours, therefore there is a risk of sampling inaccuracy/inadequacy for CNB 8. Moreover, the overall architecture of SA-BC is not consistently recognisable in those small CNB samples.…”

Section: Discussionmentioning

confidence: 99%

“…The stroma in SA-CIS is mainly composed of proliferated collagen and fibrosis, compared with more cellular desmoplastic stroma in invasive carcinoma. Identification of myoepithelial cells surrounding the atypical glands by careful inspection and auxiliary IHC staining can rule out the possibility of invasive carcinoma 8. Another situation that may cause confusion with SA-BC is SA with florid hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

“…As for topographical type B ones, it would be harder to distinguish whether carcinoma arises from SA and then grows beyond it, or originally intrudes from the area outside SA. Moritani et al considered that type B might comprise heterogeneous groups of lesions, that is, some might arise within SA while others would originate external to it 8. How one decides which one is the case might resort to complex molecular methods, not just histological cutoffs and clinicopathological context.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies also have analysed the topographical patterns of SA-BC, whereas the methods for topographical classification differed 6–8. Moritani et al divided 24 cases of carcinoma in situ (CIS) involving SA into topographical type A (CIS entirely surrounded by SA) and type B (CIS involved SA at least focally but was not confined to the SA area), and revealed that most type A CIS cases were non-high-grade and ER+/PR+/HER2− immunophenotype predominated, whereas most type B cases were high-grade and nearly half were ER−/PR− 8. However, the clinicopathological relevance of the topographical pattern of SA-BC cases, including those in situ and invasive ones, has not yet been comprehensively evaluated in larger series.…”

Section: Introductionmentioning

confidence: 99%

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Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions

Tang

et al. 2018

J Clin Pathol

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CIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions

Tang

et al. 2018

J Clin Pathol

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“…20,21 Some studies have previously demonstrated that SA cases are often considered to be hormone positive. 22 …”

Section: Discussionmentioning

confidence: 99%

Breast Sclerosing Adenosis and Accompanying Malignancies

et al. 2015

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Sclerosing adenosis (SA) is a less common histopathological lesion of the breast that can coexist with proliferative lesions as well as malignancies. We aimed to analyze the clinicopathological characteristics of SA and to investigate the radiological features of SA.Patients who underwent breast surgery at our institute from 2007 to 2013 were retrospectively reviewed. A total of 815 breasts (722 patients) were included in the final analysis. Synchronous bilateral SA was defined as the detection of another SA arising in the contralateral breast within 1 month after surgery for the initial breast lesion. Baseline characteristics, imaging records (ultrasonography, mammography, and magnetic resonance imaging [MRI]), and pathology were included in the analysis.The median age at diagnosis was 47 years old. The majority of patients had unilateral non-Bc-SA (457/722). Among 102 patients with bilateral SA, 78.4% were diagnosed synchronously. In total, 26 patients suffered from synchronous bilateral breast cancer. Upon final pathological investigation, 226 cases were SA involving breast cancer (Bc-SA), most (56.2%) of which were ductal carcinoma in situ (DCIS). In addition, lobular carcinoma in situ (LCIS) and diseases that involved LCIS also comprised up to 11.1% of cases. The majority of SA cases (405; 49.7%) had no obvious symptoms except for imaging changes in mammography or ultrasound. Compared with non-Bc-SA cases, Bc-SA cases were more likely to exhibit features of mass (32.8% vs. 28.6%) and architectural distortion (20.4% vs. 13.0%) on mammography. Ultrasonography, mammography, and MRI revealed unsatisfactory sensitivity and specificity to differentiate Bc-SA from non-Bc-SA. MRI exhibited the highest sensitivity and lowest specificity, whereas the specificity of mammography was as low as 50.0%.A tendency for synchronous bilaterality in both Bc-SA and non-Bc-SA was noted. DCIS was the most commonly observed malignancy involved in Bc-SA. Although most patients with SA were asymptomatic, the ability of imaging studies to accurately differentiate non-Bc-SA from Bc-SA remained unsatisfactory.

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Improving contrast and spatial resolution in crystal analyzer‐based x‐ray dark‐field imaging: Theoretical considerations and experimental demonstration

Ando

Nakao

et al. 2020

Medical Physics

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Purpose This paper describes and experimentally validates a methodology for improving contrast and spatial resolution of the x‐ray dark‐field imaging (XDFI) by cutting the monochromator‐collimator asymmetrically and thinning the Laue angle analyzer. Methods We measure the spatial resolution of our XDFI setup using a test object consisting of wolfram tungsten meshes and compare it with the theoretical prediction. Using x‐ray dark‐field computed tomography of breast cancer specimens (lobular carcinoma in situ), we demonstrate that the resolution of XDFI is sufficient for histopathologic analysis. Results Our experimental results show that the overall spatial resolution of XDFI can be improved by approximately a factor of 2 when these modifications are implemented. The reconstructed images of breast cancer specimens provide sufficient details for radiologic histopathology. Conclusions By cutting the monochromator‐collimator and thinning the Laue angle analyzer, XDFI can achieve the resolution sufficient for radiologic histopathology.

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Topographical, morphological and immunohistochemical characteristics of carcinoma in situ of the breast involving sclerosing adenosis. Two distinct topographical patterns and histological types of carcinoma in situ

Abstract: Most CIS involving SA arises within SA and high-grade DCIS tends to grow beyond SA. Occasional CIS may arise outside SA and secondarily involve SA.

Cited by 21 publications

References 28 publications

Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions

Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions

Breast Sclerosing Adenosis and Accompanying Malignancies

Improving contrast and spatial resolution in crystal analyzer‐based x‐ray dark‐field imaging: Theoretical considerations and experimental demonstration

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