Topological charge-density method of identifying phase singularities in cardiac fibrillation

He, Yin-Jie; Li, Qi-Hao; Zhou, Kuangshi; Jiang, Ruhong; Jiang, Chenyang; Pan, Jun-Ting; Zheng, Dafang; Zheng, Bo; Zhang, Hong

doi:10.1103/physreve.104.014213

Cited by 10 publications

(2 citation statements)

References 32 publications

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“…However, most PM methods require a regular grid and can be prone to errors [15] . Although more systematic research is needed, meandering [16] , [17] , fibrosis [18] , and noise [19] , [20] , [21] , [22] , [23] have been shown to negatively affect the detection of rotors of PM.…”

Section: Introductionmentioning

confidence: 99%

Directed Graph Mapping exceeds Phase Mapping for the detection of simulated 2D meandering rotors in fibrotic tissue with added noise

Lootens,

Janssens,

Van Den Abeele

et al. 2024

Computers in Biology and Medicine

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Section: Introductionmentioning

confidence: 99%

Directed Graph Mapping exceeds Phase Mapping for the detection of simulated 2D meandering rotors in fibrotic tissue with added noise

Lootens,

Janssens,

Van Den Abeele

et al. 2024

Computers in Biology and Medicine

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“…Moreover, the focal activity or reentrant seeds of spiral waves are organized by sites known as singularities (PS). Considerable efforts have been undertaken to determine the position of PSs [30,31], given that the drift of spiral waves often originates from their motion [32].…”

Section: Introductionmentioning

confidence: 99%

Chirality and curvature determine the meandering of spirals in multilayer excitable media

Nezhad Hajian,

Parastesh,

Rajagopal

et al. 2023

Proc. R. Soc. A.

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We study the emergence of meandering spiral waves in a multilayer structure where two spirals, originating independently, evolve in space–time. The FitzHugh-Nagumo model, enhanced with electromagnetic induction effects, defines the nodal dynamics. The layers are chemically coupled, and the drift of spirals is influenced by interlayer flux coupling. An external magnetic flux force is also necessary to destabilize and unpin spiral rotors. The effects of unique characteristics of spiral patterns, like chirality and tip curvature, are assessed. We find that spirals often drift within a bounded meandering area; however, determining the drift directions and overall meandering regions is complex. The forced spiral generally drifts a greater distance, except for identical co-rotating spirals, which drift synchronously. Spirals with opposite chirality exhibit asynchronous drift and wavefront asymmetry, even with identical tip curvature. Regardless of chirality, non-identical spirals are geometrically aligned and amplified before drifting. Stimulating the more loosely curved spiral ensures both spirals drift.

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Control of spiral waves in myocardial tissue by optogenetics and temperature

Hu,

Ding,

et al. 2024

Nonlinear Dyn

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Optogenetics as an emerging technology can eliminate spiral waves in myocardial tissue. The heat generated during illumination of myocardial tissue is an overlooked influence. Even small fluctuations in temperature may affect the action potentials of cardiomyocyte. In this paper, a minimal ventricular model and a simplified model of optogenetics are employed to study the effects of heat generation by illumination on elimination of spiral waves. The Luo-Rudy model and Channelrhodospin-2 light-sensitive ion channel model are used to validate our conclusions. Weinduce drift of spiral waves through inhomogeneities generated by discrete gradients of illumination. The inhomogeneity of temperature caused by gradient illumination can inhibit the elimination of spiral waves. Spiral waves in the myocardial medium can be induced to drift more efficiently by controlling temperature changes in the myocardial medium during illumination. We emphasized the importance of temperature factors in optogenetic experiments, hoping that our results could provide guidance for its clinical applications.

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Topological charge-density method of identifying phase singularities in cardiac fibrillation

Cited by 10 publications

References 32 publications

Directed Graph Mapping exceeds Phase Mapping for the detection of simulated 2D meandering rotors in fibrotic tissue with added noise

Directed Graph Mapping exceeds Phase Mapping for the detection of simulated 2D meandering rotors in fibrotic tissue with added noise

Chirality and curvature determine the meandering of spirals in multilayer excitable media

Control of spiral waves in myocardial tissue by optogenetics and temperature

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