Total Antioxidant, Antimicrobial, Antiproliferative Potentials and Element Contents of Wild Mushroom Candolleomyces candolleanus (Agaricomycetes) from Turkey

Karaltı, İskender; Eraslan, Emre Cem; Sarıdoğan, Beste Gizem Özbey; Akata, İlgaz; Sevindik, Mustafa

doi:10.1615/intjmedmushrooms.2022045389

Cited by 11 publications

(5 citation statements)

References 35 publications

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“…In one of these studies, Agrocybe praecox mushroom had a TAS value of 2.97 mmol/L, a TOS value of 7.63 µmol/L, and an OSI value of 0.26 [42]. The TAS value of Candolleomyces candolleanus has been reported as 5.547 mmol/L, the TOS value as 8.572 µmol/L, and the OSI value as 0.155 [43]. The TAS value of Entoloma sinuatum was recorded as 2.64 mmol/L, the TOS value as 6.58 µmol/L, and the OSI value as 0.25 [44].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Sevindik,

Gürgen,

Khassanov

et al. 2024

Foods

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Mushrooms are one of the indispensable elements of human diets. Edible mushrooms stand out with their aroma and nutritional properties. In this study, some biological activities of the wild edible mushroom Hericium erinaceus were determined. In this context, firstly, the most suitable extraction conditions of the fungus in terms of biological activity were determined. First, 64 different experiments were performed with the Soxhlet device under 40–70 °C extraction temperature, 3–9 h extraction time, and 0.5–2 mg/mL extraction conditions. As a result, a total antioxidant status (TAS) analysis was performed, and the extraction conditions were optimized so that the objective function was the maximum TAS value. The data obtained from the experimental study were modeled with artificial neural networks (ANNs), one of the artificial intelligence methods, and optimized with a genetic algorithm (GA). All subsequent tests were performed using the extract obtained under optimum extraction conditions. The antioxidant capacity of the mushroom was assessed using Rel assay kits and the DPPH and FRAP techniques. The agar dilution method was used to measure the antimicrobial activity. The anti-Alzheimer activity was assessed based on the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The antiproliferative activity was assessed against the A549 cancer cell line. The total phenolic content was measured using the Folin–Ciocalteu reagent. The measurement of total flavonoids was conducted using the aluminum chloride test. LC-MS/MS equipment was used to screen for the presence of standard chemicals. The optimum extraction conditions were found to be a 60.667 °C temperature, 7.833 h, and 1.98 mg/mL. It was determined that the mushroom has high antioxidant potential. It was determined that the substance was successful at combating common bacterial and fungal strains when used at dosages ranging from 25 to 200 µg/mL. The high antiproliferative effect of the substance was attributed to its heightened concentration. The anti-AChE value was found to be 13.85 μg/mL, while the anti-BChE value was confirmed to be 28.00 μg/mL. The phenolic analysis of the mushroom revealed the presence of 13 chemicals. This investigation found that H. erinaceus exhibits robust biological activity when extracted under appropriate circumstances.

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Section: Antioxidant Activitymentioning

confidence: 99%

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Sevindik,

Gürgen,

Khassanov

et al. 2024

Foods

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“…The TAS value of the Agrocybe praecox mushroom was reported as 2.97, TOS value 7.63 and OSI value 0.26 [32]. The TAS value of Candolleomyces candolleanus was reported as 5.547, TOS value as 8.572 and OSI value as 0.155 [33]. The TAS value of Entoloma sinuatum was reported as 2.64, TOS value 6.58 and OSI value 0.25 [34].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Sevindik,

Gürgen,

Khassanov

et al. 2024

Preprint

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“…As a result of the metabolic processes of living organisms, reactive oxygen species, which are oxidant chemicals, are produced. These oxidizing chemicals can be helpful as catalysts at low concentrations, but can be harmful at higher concentrations [26]. The antioxidant defense system suppresses or eliminates the effects of these harmful oxidant compounds.…”

Section: Total Phenolic Contents and Antioxidant Activitymentioning

confidence: 99%

Antioxidant, Antimicrobial Activities, Total Phenolic and Element Contents of Wild Edible Mushroom Bovista nigrescens

Bal¹,

Eraslan²,

Sevindik³

2023

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Mushrooms are natural materials that spread in cosmopolitan manner. In this study, antimicrobial and antioxidant properties of wild mushroom Bovista nigrescens Pers were determined. In addition, the total phenolic contents and element levels of the mushroom were determined. The mushroom was extracted with ethanol and methanol in a soxhlet apparatus. The antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were measured using Rel Assay Diagnostics (Mega Tıp/Türkiye) kits. The agar dilution technique was used to test for antimicrobial activity. To quantify total phenolic content, the Folin-Ciocalteu reagent was utilised. A device that uses atomic absorption to measure element concentrations was used. The results showed that the TAS value was the greatest in the ethanol extract. Methanol extract was found to have the highest values of both TOS and OSI. Ethanol extracts were shown to be effective against bacterial strains at concentrations of 50-200 μg/mL and against fungal strains at 100 μg/mL. The methanol extract was shown to be effective against bacteria at concentrations between 100 and 400 μg/mL, and against fungi at concentrations between 100 and 200 μg/mL. The ethanol extract and the methanol extract had total phenolic contents of 46.83±4.77 mg/g and 39.22±4.86 mg/g, respectively. Overall, element concentrations were determined to be consistent with what is reported in the literature. However, it was found that Pb content was rather high. Therefore, B. nigrescens was shown to possess antioxidant and antibacterial properties.

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Total Antioxidant, Antimicrobial, Antiproliferative Potentials and Element Contents of Wild Mushroom Candolleomyces candolleanus (Agaricomycetes) from Turkey

Cited by 11 publications

References 35 publications

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Antioxidant, Antimicrobial Activities, Total Phenolic and Element Contents of Wild Edible Mushroom Bovista nigrescens

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