Total antioxidant level is correlated with intra-ocular pressure in patients with primary angle closure glaucoma

Abstract

BackgroundTo evaluate total antioxidant status (TAS) in the plasma of primary angle closure glaucoma (PACG) patients and to compare it to that of the control group. Additionally, we aim to investigate the association of various PACG clinical indices with TAS level.MethodsPlasma samples were obtained from 139 PACG patients and 149 glaucoma-free controls of matching age, sex, and ethnicity. TAS in all samples was determined by spectrophotometric and enzyme-linked immunosorbent assay methods. We studied the possible association of the TAS level with various clinical indices relevant to PACG.ResultsThe mean (±SD) total antioxidant (TAS) value was almost similar in patients 1 (±0.22) compared to controls 0.97 (±0.43); p = 0.345. Among cases, mean TAS concentration showed a statistically significant lower pattern among subjects with glaucoma onset at the age of ≤ 50 years (p = 0.037) and female subjects (p = 0.014) as well as having a family history of glaucoma (p = 0.010). Interestingly, a statistically significant inverse correlation was detected between TAS concentration and intra ocular pressure (IOP), (R = -0.14, p = 0.037).ConclusionsThe inverse correlation of TAS level with IOP, highlights TAS potential role as a predictive-marker for PACG-severity.

Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis

“…Removal of duplicates and use of the selection criteria reduced the number of articles reporting the evaluation of oxidative or antioxidative markers in aqueous humor or blood to 22 articles [27–48]. All articles were written in English.…”

“…Levels of oxidant or antioxidant markers were evaluated in serum in 12 studies [27,28,29,31,32,34,35,39,40,43,45,48], in aqueous humor in six studies [30,36,37,38,44,47], or both in three studies [33,41,42]. One study measured the markers in blood hemolysate [46].…”

“…The markers were measured in different types of glaucoma: only in primary open angle glaucoma (POAG) [29,30,36,37,39,41,43,44,45,46,48], only in primary angle closure glaucoma (PACG) [27,31], only in pseudoexfoliation glaucoma (PEG) [28,32,33], in both POAG and PACG [38], in both POAG and PEG [35,42,47], in both POAG, PACG and PEG [40], or it was not specified [34]. Inclusion criteria for glaucoma patients were similar for most studies [27–33,35–39,41,43,46,47].…”

“…Inclusion criteria for glaucoma patients were similar for most studies [27–33,35–39,41,43,46,47]. Patients had to have a vertical cup/disc ratio of 0.5 or higher and a typical glaucomatous defect at the visual field (standard automatized visual field analyser).…”

“…Some specificities were required for each type of glaucoma, such as an open angle for the gonioscopy for POAG [29,30,36,37,38,39,41,43,46,48], a close angle for PACG [27,31,38], or clinical evidence of exfoliative material on the pupil margin or anterior lens surface for PEG [28,32,33,35,47]. Some studies required an elevation of the intraocular pressure for glaucoma patients [27,28,32,33,35,37,38,43,48]. Criteria for glaucoma were not defined in five studies [34,40,42,44,45].…”