Total Body Irradiation before Bone Marrow Transplantation

Abstract

Our technique with the large source-midline distance, vertical beam direction and the supine/prone position is stable, convenient and safe to produce homogeneous dose distribution and ensures accurate and reproducible lung shielding.

Patterns of patient specific dosimetry in total body irradiation

“…Total body irradiation (TBI) has been an integral part of bone marrow transplant regimens for hematologic and immune deficiency conditions since first published in 1957 by Thomas et al 1 TBI provides cytotoxic, immunoablative, and myeloablative therapeutic benefit when used in conjunction with chemotherapy as a conditioning regimen for bone marrow transplantation or peripheral blood stem cell transplantation. [2][3][4] Total body irradiation has been delivered using both single 5,6 and multifraction approaches, but in the modern era, most centers favor multifraction approaches. Cobalt-60 and linear accelerator based approaches can deliver an adequately low dose rate (10-16 cGy/min) to limit both acute and late morbidity related to TBI.…”

Estudo de parâmetros dosimétricos e dosimetria in vivo em radioterapia

“…As doses totais do tratamento são, geralmente, de 12 Gy, com taxas de doses de até algumas poucos décimos de grays por minuto (PALKOSKOVÁ el al., 2002;VRTAR, 2002;HEINZELANN et al, 2006). Pela extensão da região de tratamento, são empregados campos extensos, em média de 150 x 150 cm 2 , posicionando-se o paciente em grandes distancias da fonte de radiação, sendo essas distâncias de, em média, 350 cm (AAPM, 1986;PLANSKOY et al, 1996;BAN et al, 1997;SZÉKELY et al, 1999;ARISTEI et al, 2001;VRTAR et al, 2002).…”