Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females

Liang, Jingjia; Xu, Cheng; Liu, Qian; Weng, Zhenkun; Zhang, Xin; Xu, Jin; Gu, Aihua

doi:10.1007/s11356-021-18342-0

Cited by 10 publications

(8 citation statements)

References 44 publications

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“…In vivo and in vitro studies have shown that AA and its main metabolite glycidamide (GA) are carcinogenic, neurotoxic, reprotoxic and toxic for the developmental system 3 . Emerging evidence also links AA exposure to several other diseases 5 – 8 . In humans, the association between AA and cancer risk, investigated in epidemiological studies, remains unclear 9 .…”

Section: Introductionmentioning

confidence: 99%

Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies

F. Fernández,

Poteser,

Govarts

et al. 2023

Sci Rep

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Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014–2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3–18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20–45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (µg/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:β = − 9.1 µg/g creatinine, 95% CI − 15.8, − 2.4; GAMA: β = − 3.4 µg/g creatinine, 95% CI − 4.7, − 2.2), living in rural areas (AAMA:β = − 4.7 µg/g creatinine, 95% CI − 8.6, − 0.8; GAMA:β = − 1.1 µg/g creatinine, 95% CI − 1.9, − 0.4) and increasing age (AAMA:β = − 1.9 µg/g creatinine, 95% CI − 2.4, − 1.4; GAMA:β = − 0.7 µg/g creatinine, 95% CI − 0.8, − 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries.

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Section: Introductionmentioning

confidence: 99%

Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies

F. Fernández,

Poteser,

Govarts

et al. 2023

Sci Rep

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“…There have been few population studies on the association between VOCs and serum lipids, and most studies have analyzed a single VOC [ 18 , 19 , 26 ]. One study reported the combined effect of several VOCs in the occupational environment on serum lipids among nail technicians or petrochemical industry employees, which has limited generalizability to the general population [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Based on previous studies, covariates may influence the association between VOC concentration and serum lipid levels [17][18][19]. Continuous variables, including age, serum cotinine, energy intake and physical activity, were treated as continuous variables.…”

Section: Covariatesmentioning

confidence: 99%

“…Wiglusz et al found that white male Wistar rats were exposed to VOCs for 3 months and that triglycerides decreased [ 17 ]. Liang et al reported that exposure to acrylamide in adolescent women can increase total cholesterol levels [ 18 ]. One population-based study showed that 1,3-butadiene urinary metabolite levels were positively correlated with triglycerides and low-density lipoprotein cholesterol [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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The association between exposure to volatile organic compounds and serum lipids in the US adult population

Chen,

Fu,

et al. 2023

Lipids Health Dis

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Background and Aim Epidemiological evidence on the relationship between exposure to volatile organic compounds (VOCs), both single and mixed, and serum lipid levels is limited, and their relationship remains unclear. Our study aimed to investigate the associations of exposure to VOCs with serum lipid levels in the US adult population. Methods and results The study examined the association of 16 VOC levels (2-methylhippuric acid, 3- and 4-methylhippuric acid, N-acetyl-S-(2-carbamoylethyl)-L-cysteine, N-acetyl-S-(N-methylcarbamoyl)-L-cysteine, 2-aminothiazoline-4-carboxylic acid, N-acetyl-S-(benzyl)-L-cysteine, N-acetyl-S-(n-propyl)-L-cysteine, N-acetyl-S-(2-carboxyethyl)-L-cysteine, N-acetyl-S-(2-cyanoethyl)-L-cysteine, N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine, N-acetyl-S-(2-hydroxypropyl)-L-cysteine. N-Acetyl-S-(3-hydroxypropyl)-L-cysteine, mandelic acid, N-acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine, phenylglyoxylic acid and N-acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine) with total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) using data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2015, and a total of 1410 adults were enrolled. The association was evaluated by Bayesian kernel machine regression (BKMR), multiple linear regression and weighted quantile sum (WQS) regression. In BKMR analysis, exposure to VOCs is positively correlated with levels of TC, TG, and LDL-C. However, statistical significance was observed only for the impact on TG. Our linear regression analysis and WQS regression generally support the BKMR results. Several VOCs were positively associated with serum lipid profiles (e.g., the ln-transformed level of mandelic acid (MA) displayed an increase in estimated changes of 7.01 (95% CIs: 2.78, 11.24) mg/dL for TC level), even after the effective number of tests for multiple testing (P < 0.05). Conclusions Exposure to VOCs was associated with serum lipids, and more studies are needed to confirm these findings.

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“…Data for the US population were obtained from NHANES, an ongoing cross-sectional survey conducted by the US Centers for Disease Control and Prevention (CDC) to evaluate the general health and chemical exposures of the population. Detailed methods of respondent selection, data collection, and laboratory analyses are described elsewhere . A stratified, multistage probability cluster design was performed in NHANES, and detailed information on demographics, socioeconomic data, personal lifestyle, individual medical and health conditions, and laboratory indicators was collected.…”

Section: Methodsmentioning

confidence: 99%

PPARα Senses Bisphenol S to Trigger EP300-Mediated Autophagy Blockage and Hepatic Steatosis

Liang,

Xu,

et al. 2023

Environ. Sci. Technol.

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Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females

Cited by 10 publications

References 44 publications

Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies

Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies

The association between exposure to volatile organic compounds and serum lipids in the US adult population

PPARα Senses Bisphenol S to Trigger EP300-Mediated Autophagy Blockage and Hepatic Steatosis

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