Total Cholesterol (Tc), Low-Density Lipoprotein Cholesterol (Ldl-C) And High-Density Lipoprotein Cholesterol (Hdl-C) Levels In Patients With Hypertension (Ht), Diabetes (Dm), Both (Ht And Dm) And Chronic Kidney Disease (Ckd)

Acuña, Lizbeth; Sánchez, Paula Morales; Soler, LA; Alvis, LF

doi:10.1016/j.jval.2015.09.950

Cited by 6 publications

(4 citation statements)

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“…Among these, 351 articles were excluded after title screening and the abstract of the 784 remaining papers was assessed. Finally, 461 publications were excluded following the eligibility criteria and thus, 323 articles that had interpretable data and fulfilled the eligibility criteria were used for data extraction…”

Section: Resultsmentioning

confidence: 99%

“…The High Cost Account (CAC), which was created by the government in 2007 and is administered by insurers, collects healthcare data on high‐cost diseases (eg cancer, diabetes, hemophilia, rheumatic diseases, etc) 21,22,132,212,234,243,248,250,251,277 . This database has a quality control process (audit through a validation mesh and verification against the medical record) and contains demographic data, diagnosis by ICD‐10 and prescriptions.…”

Section: Resultsmentioning

confidence: 99%

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Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review

Franco¹,

Vizcaya²

2020

Pharmacology Res & Perspec

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review

Franco¹,

Vizcaya²

2020

Pharmacology Res & Perspec

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“…Most importantly, KLKs are associated with hypertension ( 29 , 30 ), while cholesterol is also associated with hypertension ( 27 , 28 ) which is an important clinical symptoms of HAPC. Thus, in this study, we explored the interaction between KLKs and cholesterol using AutoDock remodeling.…”

Section: Discussionmentioning

confidence: 99%

“…Cholosterol has been widely reported to be associated with hypertension ( 27 , 28 ), while kallikrein hypertension is also well known ( 29 , 30 ). Thus, in this study, we explored the interaction between KLKs and cholesterol using the software PyMOL v1.8 ( https://www.pymol.org ) and AutoDock 4.2.6 ( http://autodock.scripps.edu ).…”

Section: Methodsmentioning

confidence: 99%

Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia

Gesang

Zhang

et al. 2016

International Journal of Molecular Medicine

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High altitude-associated polycythemia (HAPC) is a very common disease. However, it the disease is still unmanageable and the related molecular mechanisms remain largely unclear. In the present study, we aimed to explore the molecular mechanisms responsible for the development of HAPC using transcriptome analysis. Transcriptome analysis was conducted in 3 pairs of gastric mucosa tissues from patients with HAPC and healthy residents at a similar altitude. Endoscopy and histopathological analyses were used to examine the injury to gastric tissues. Molecular remodeling was performed for the interaction between different KLK members and cholesterol. HAPC was found to lead to morphological changes and pathological damage to the gastric mucosa of patients. A total of 10,304 differentially expressed genes (DEGs) were identified. Among these genes, 4,941 DEGs were upregulated, while 5,363 DEGs were downregulated in the patients with HAPC (fold change ≥2, P<0.01 and FDR <0.01). In particular, the kallikrein gene cluster (KLK1/3/7/8/12) was upregulated >17-fold. All the members had high-score binding cholesterol, particularly for the polymers of KLK7. The kallikrein gene cluster (KLK1/3/7/8/12) is on chromosome 19q13.3–13.4. The elevated levels of KLK1, KLK3, KLK7, KLK8 and KLK12 may be closely associated with the hypertension, inflammation, obesity and other gastric injuries associated with polycythemia. The interaction of KLKs and cholesterol maybe play an important role in the development of hypertension. The findings of the present study revealed that HAPC induces gastric injury by upregulating the kallikrein gene cluster (KLK1/3/7/8/12), which can bind cholesterol and result in kallikrein hypertension. These findings provide some basic information for understanding the molecular mechanisms responsible for HAPC and HAPC-related diseases.

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Fibroblast Growth Factor 21 Ameliorates Endothelin I-Induced Hypertension Partly Through PPAR γ Pathway

Zhang

et al. 2022

Int J Pept Res Ther

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Total Cholesterol (Tc), Low-Density Lipoprotein Cholesterol (Ldl-C) And High-Density Lipoprotein Cholesterol (Hdl-C) Levels In Patients With Hypertension (Ht), Diabetes (Dm), Both (Ht And Dm) And Chronic Kidney Disease (Ckd)

Cited by 6 publications

References 0 publications

Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review

Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review

Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia

Fibroblast Growth Factor 21 Ameliorates Endothelin I-Induced Hypertension Partly Through PPAR γ Pathway

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