Total Fluoride Intake and Urinary Excretion in German Children Aged 3–6 Years

Haftenberger, Marjolein; Viergutz, Gabriele; Neumeister, Volker; Hetzer, G

doi:10.1159/000047489

Cited by 47 publications

(44 citation statements)

References 14 publications

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“…The present findings were also higher that those of Haftenberger et al, (27). The differences were possibly due to the employment of fluoride content stated on manufacturers' label in the calculations of fluoride ingested in the German study.…”

Section: Discussioncontrasting

confidence: 71%

Past Fluoride Exposure From Ingested Toothpaste Extrapolated From Younger Siblings And Fluorosis Status

Tan

Razak

Foo³

2004

ADUM

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The aim of the study was to assess the association between past fluoride exposures from ingested toothpaste and current fluorosis manifestations in 10-11 year old index subjects. Fluorosis was assessed with the Dean's Index in 1343 10-11 year old index subjects. Two hundred index subjects who had younger 4-5 year old siblings were sub sampled and fluoride exposures from ingested toothpaste in their younger siblings (proxy subjects) were determined. The values for the fluoride ingested per brushing of the proxy subjects were utilised together with past frequency of toothbrushing of index subjects to extrapolate on the past exposure of index subjects.The mean extrapolated past fluoride exposure from ingestion of toothpaste was highly variable; 671.7 ug ± 739.3 ug (sem= 56.9). It was higher in the subjects with fluorosis (697.3 ug) than in those without fluorosis (646.89 ug) but differences were not of statistical significance. This approach of extrapolation has not been reported elsewhere and need to be validated. The implications of the present methodology to estimate past fluoride exposure is discussed.

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Section: Discussioncontrasting

confidence: 71%

Past Fluoride Exposure From Ingested Toothpaste Extrapolated From Younger Siblings And Fluorosis Status

Tan

Razak

Foo³

2004

ADUM

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“…While the first reports of simultaneous measurement of TDFI and daily urinary fluoride excretion (DUFE) were published many years ago, several studies have been undertaken recently (partly due to the need to learn of the relative importance of the many sources of ingested fluoride and the increasing risk of dental fluorosis) in children [Ekstrand et al, 1984[Ekstrand et al, , 1994Villa et al, 2000;Zohouri and Rugg-Gunn, 2000;Haftenberger et al, 2001;Franco et al, 2005;Zohouri et al, 2006;Maguire et al, 2007] and adults [Maheshwari et al, 1981;Spencer et al, 1970Spencer et al, , 1975Villa et al, 2004Villa et al, , 2008. It was thought desirable to bring this information together so as to examine more closely the relationship between TDFI, DUFE and daily fluoride retention (DFR) in order to assist understanding of these physiological variables.…”

mentioning

confidence: 99%

Relationships between Fluoride Intake, Urinary Fluoride Excretion and Fluoride Retention in Children and Adults: An Analysis of Available Data

et al. 2010

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The aim of this study was to examine the relationship between total daily fluoride intake (TDFI), daily urinary fluoride excretion (DUFE) and fractional fluoride retention (FFR) using available data, in order to clarify the ability of DUFE to predict TDFI and, therefore, the risk of fluorosis development. Examination of published reports of simultaneous measurement of TDFI and DUFE, together with data from two unpublished Chilean studies, yielded data for 212 children aged less than 7 years and for 283 adults aged 18–75 years, providing a total of 212 and 269 data points, respectively. The relationship between DUFE and TDFI was studied for children and adults, separately. Daily fluoride retention (DFR) was estimated as a function of TDFI in children and adults assuming an average 90% fluoride absorption, and the numerical relationships between the estimated FFR and the TDFI were explored. Limiting FFR values of 0.55 and 0.36 were found for children and adults, respectively, above a threshold of TDFI of 0.5 and 2 mg, respectively. Neutral fluoride balances were predicted when the TDFI was equal to approximately 0.07 mg F/day for children and 0.8 mg F/day for adults. For children and adults, it is possible to obtain reasonably good estimations of community-based TDFI and DFR, using DUFE data. The advantages and limitations of these relationships, together with the need for future studies, are discussed.

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“…Accepting that approximately 10% of the fluoride intake is not absorbed, the daily fluoride retention can be preliminarily estimated as 20% of the ingested fluoride. Copyright © 2008 S. Karger AG, Basel Over recent decades, several studies have been published on the proportion of ingested fluoride that is excreted in the urine [fractional urinary fluoride excretion (FUFE)] in young children [Ekstrand et al, 1984[Ekstrand et al, , 1994aVilla et al, 1999Villa et al, , 2000 Lennon, 2000, 2001;Zohouri and Rugg-Gunn, 2000;Haftenberger et al, 2001;Franco et al, 2005]. On the other hand, studies on FUFE in adults, under usual fluoride intake conditions, are very scarce.…”

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confidence: 99%

Fractional Urinary Fluoride Excretion of Young Female Adults during the Diurnal and Nocturnal Periods

et al. 2008

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Objectives: This study aimed to confirm a previously obtained value for the fractional urinary fluoride excretion (FUFE) over a 24-hour period in adults and to assess whether there are significant differences between FUFE measured during the diurnal (7 a.m. and 6 p.m.) and the subsequent nocturnal (6 p.m. until 7 a.m. of the following day) periods. Methods: Urine was collected over 24 h from 60 healthy female volunteers residing in Santiago, Chile. The individuals’ fluoride intakes over the diurnal and nocturnal periods were calculated from their corresponding F ingestion, measured by dietary analysis. Separate urine collections during both periods were obtained from each volunteer. The fluoride concentrations were measured with a fluoride-ion-selective electrode either directly (urine, water and beverages) or after sample treatment with the microdiffusion technique (food). Results: The average 24-hour FUFE value was 0.69, with a 95% CI of 0.65–0.72, while the average FUFE for the diurnal period was 0.46 (95% CI: 0.42–0.50), and the corresponding result for the nocturnal period showed a significantly higher (paired t test, p < 0.0001) amount of 1.09 (95% CI: 0.97–1.22). Conclusions: A recently published result for the daily FUFE value (0.71) in adults was confirmed. The diurnal average FUFE value is significantly lower than the average nocturnal one. Accepting that approximately 10% of the fluoride intake is not absorbed, the daily fluoride retention can be preliminarily estimated as 20% of the ingested fluoride.

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Total Fluoride Intake and Urinary Excretion in German Children Aged 3–6 Years

Cited by 47 publications

References 14 publications

Past Fluoride Exposure From Ingested Toothpaste Extrapolated From Younger Siblings And Fluorosis Status

Past Fluoride Exposure From Ingested Toothpaste Extrapolated From Younger Siblings And Fluorosis Status

Relationships between Fluoride Intake, Urinary Fluoride Excretion and Fluoride Retention in Children and Adults: An Analysis of Available Data

Fractional Urinary Fluoride Excretion of Young Female Adults during the Diurnal and Nocturnal Periods

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