Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis

Bao, Jiayu; Tian, Lei; Meng, Yifan; Wu, Binge; Wang, Jingyi; Jing, He; Shao, Qiyan; Jin, Ying; Zhang, Luo

doi:10.1002/clt2.12139

Cited by 16 publications

(8 citation statements)

References 48 publications

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“…Regarding allergy test results, although Inada et al [21] and Mimura et al [33] state that t-tIgE levels are similar to s-tIgE levels, in this study, the proportion of s-tIgE positivity was lower than the proportion of t-tIgE positivity. (Table 3) It has also been reported that there was no correlation between t-tIgE and s-tIgE, and this may be due to the difference in severity of allergic conjunctivitis patients at general clinics and hospitals [34]. However, as reported [33,35] there is a relationship between positive t-tIgE and s-sIgE, this study also found a relationship between the two (Table 4).…”

Section: Discussionsupporting

confidence: 52%

JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

Yamana,

Uchio

2024

Preprint

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Background: We investigated the relationship between subjective symptoms and objective findings in patients with allergic conjunctival diseases (ACD) and test results for tear total IgE (t-tIgE), conjunctival eosinophils (c-Eo), serum total IgE (s-tIgE), and serum-antigen specific IgE (s-sIgE) serum eosinophils (s-Eo).Methods: Subjective symptoms and objective findings of patients with ACD were evaluated using Japanese Allergic Conjunctival Disease Quality of Life Questionnaire (JACQLQ), which described disability score and emotional score written by patient and clinical findings score written by ophthalmologist. We investigated the relationship between questionnaire scores and laboratory data for t-tIgE, c-Eo, s-tIgE, s-sIgE, and s-Eo.Results: Scores of impediments to life and of moods were highest in vernal keratoconjunctivitis among ACD. Cases with positive pollen-sIgE showed significantly more nasal symptom score than those with negative pollen-sIgE (P < 0.05). Cases with positive t-tIgE or c-Eo showed significantly more objective symptoms’ JACQLQ score than those with negative t-tIgE or c-Eo (P < 0.05), respectively. Cases positive for house dust/mite-sIgE, showed significantly more objective symptoms’ JACQLQ score than those without for house dust/mite-sIgE (P < 0.05).Conclusions: These results indicate that ACD could be analyzed more accurately by the combination of JACQLQ and laboratory data.

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Section: Discussionsupporting

confidence: 52%

JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

Yamana,

Uchio

2024

Preprint

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“…First, the serum IgE level was not measured because of its invasive procedure. Although it was reported that the total IgE concentration in the serum did not correlate with the severity of ocular symptoms (5) , this index should be involved in future research,…”

Section: Discussionmentioning

confidence: 95%

“…The traditional test methods of ACDs include the identification of eosinophils in the conjunctiva, instillation provocation test, and total IgE antibody measurements in the serum. 4 The total IgE antibody measurement in lacrimal fluid was reported to be helpful in the diagnosis and clinical evaluation of ACDs, 5 and several commercial kits are available in Europe and Japan. [6][7][8] However, simple and accurate diagnostic tests for ACDs remain absent from China.…”

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confidence: 99%

Novel Application of Immunochromatographic Assay for Measurement of Total Tear Immunoglobulin E

Liu

Wang

et al. 2023

Cornea

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Purpose:The aim of this study was to evaluate the efficacy of a new immunochromatographic assay (Aifeice) in the diagnosis of allergic conjunctivitis diseases (ACDs) and to explore the relationship between Aifeice testing results and the severity of ACDs.Methods:A multicenter prospective cross-sectional study (390 patients diagnosed with ACDs and 619 healthy controls) was conducted. Patients with ACDs were scored based on clinical symptoms. All participants received the Aifeice test. The positive testing results were further divided into 3 immunoglobulin E (IgE) grades. Statistical analysis was performed to evaluate the indexes associated with the testing results.Results:The sensitivity, specificity, positive predictive value, negative predictive value, and total coincidence rate of the Aifeice test were 96.15%, 98.87%, 98.17%, 97.61%, and 97.82%, respectively. The total clinical score was significantly correlated with the IgE grade. The factors that affected the IgE score were conjunctival hyperemia, conjunctival swelling, conjunctival papillae, and Horner–Trantas dots.Conclusions:The high sensitivity and specificity of Aifeice in the diagnosis of ACD was confirmed. This new immunochromatographic assay could be used to assess the severity of ACD.

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“…12,20 Also, CsA prevents the mitochondrial permeability transition (MPT) pore from opening by binding to cyclophilin D, which in turn increases the number of goblet cells and mucin secretion. 14,21 Other than that, CsA can reduce the allergic response by preventing mast cells (MCs) and basophils degranulation, and simultaneously suppressing eosinophil recruitment. 7 A recent study in mice suggested that calcineurin subunit A (CnAα) is involved in the early phases of mast cell-driven allergy reactions, and its de ciency resulted in the decrease of degranulation and in ammatory cytokines secretion in allergic responses.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Studies have revealed that total IgE in tears is a reliable predictor of the severity and prognosis of SAC patients. 14 Moreover, lymphotoxin-alpha (LT-α) is a member of the tumor necrosis factor (TNF)-related cytokines family, primarily generated by lymphocytes, which has been considered a diagnostic indicator for DE recently. 15 Apart from these, the primary relevant cytokines of ocular allergy and DE can be used as indicators of disease severity, such as IL-4, IL-5, IL-6, and TNF-α.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Efficacy and Mechanism of 0.05% Cyclosporine Eye Drops (II) Monotherapy in Allergic Conjunctivitis-associated Dry Eye

Jiao,

Qi,

Gao

et al. 2023

Preprint

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Purpose To explore the efficacy and relevant mechanism of 0.05% cyclosporine A (CsA) eye drops (II) monotherapy in patients with allergic conjunctivitis-associated dry eye (ACDE). Methods Prospective, randomized, controlled study. Fifty-three patients with mild-to-moderate ACDE were randomly assigned to two groups. The CsA group received 0.05% CsA eye drops (II) monotherapy four times daily. The control group received 0.1% olopatadine twice daily combined with 0.1% preservative-free artificial tears four times daily. Clinical symptoms and signs, tear total IgE, and lymphotoxin-α (LT-α) concentrations were assessed at pre- and post-treatment days 7, 30, and 60. And we further measured six tear inflammatory cytokines levels using a microsphere-based immunoassay. Results The CsA group showed significant improvement in symptoms (Ocular Surface Disease Index and itching scores) and signs (conjunctival hyperemia, conjunctival edema, conjunctival papillae, tear break-up time (TBUT), corneal fluorescent staining, and goblet cell density) at each follow-up period compared to pre-treatment (all P<0.050). And its improvement in itching scores (P7th<0.001, P30th=0.039, and P60th=0.031) and TBUT (P7th=0.009, P30th=0.003, and P60th=0.005) was more significant than the control group at all follow-up periods. The tear total IgE, interleukin (IL)-5, IL-6, periostin, eotaxin-3, and MMP-9 levels significantly decreased in the CsA group at day 60 after treatment (all P<0.050). And the changed values in tear total IgE were positively correlated with the change in itching scores. Conclusions 0.05% CsA eye drops (II) monotherapy can rapidly improve the symptoms and signs, especially in ocular itching and TBUT, in patients with ACDE. And its efficacy is superior to 0.1% olopatadine combined with artificial tears. Moreover, CsA downregulates the expression levels of tear inflammatory cytokines, including tear total IgE, IL-5, IL-6, periostin, eotaxin-3, and MMP-9. Among that, the reduction in tear total IgE levels may reflect the improvement of ocular itching.

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Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis

Cited by 16 publications

References 48 publications

JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

Novel Application of Immunochromatographic Assay for Measurement of Total Tear Immunoglobulin E

Exploration of Efficacy and Mechanism of 0.05% Cyclosporine Eye Drops (II) Monotherapy in Allergic Conjunctivitis-associated Dry Eye

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