Total IgE, Specific IgE and Prick-Tests Against Foods in Common Migraine—A Prospective Study

Pradalier, A; Weinman, S.; Launay, J. M.; Baron, J. F.; J, Dry

doi:10.1046/j.1468-2982.1983.0304231.x

Cited by 33 publications

(26 citation statements)

References 15 publications

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“…However, in other countries (France, Italy) white wine (in France also champagne) is viewed as the major culprit [5, 6]. In addition, another study reported a surprisingly higher correlation of spirits and sparkling wine to migraine attack, compared to other alcoholic drinks.…”

Section: Is Alcohol Per Se or Another Component Of Alcoholic Drinks Tmentioning

confidence: 99%

“…However, despite the original paper of Hanington [3] and the vigorous literature that follows, serious doubts exist as to whether the condition really exists as a clinical entity. The commonest initiator of an attack is alcoholic beverages and by far the largest and most notorious is red wine, at least in the United Kingdom [4], while in other countries, white wine (France, Italy) and champagne (France) are viewed as the major culprits [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

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Alcohol and migraine: trigger factor, consumption, mechanisms. A review

Panconesi¹

2008

J Headache Pain

123

126

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This study investigates the importance of alcohol as a migraine trigger factor, the prevalence of alcohol consumers and the mechanism of headache provocation. A MEDLINE search from 1988 to October 2007 was performed for “headache and alcohol”, “headache and wine”, “migraine and alcohol” and “migraine and wine”. In retrospective studies, about one-third of the migraine patients reported alcohol as a migraine trigger, at least occasionally, but only 10% of the migraine patients reported alcohol as a migraine trigger frequently. Regional differences were reported, perhaps depending in part on alcohol habits. No differences were found between migraine and tension headache and different genders. However, prospective studies limit considerably the importance of alcohol as a trigger. Recent studies show that migraine patients consume less alcohol than controls. Red wine was reported to be the principal trigger of migraine, but other studies show that white wine or other drinks are more involved. Then, the discussion based on the different composition of the various alcoholic beverages, in order to discover the content of alcoholic drinks responsible for migraine attack, reflects this uncertainty. Biogenic amines, sulphites, flavonoid phenols, 5-hydroxytryptamine mechanisms and vasodilating effects are discussed. The fact that few headache patients cannot tolerate some alcoholic drinks does not justify the consideration that alcohol is a major trigger and the suggestion of abstinence. In fact, low doses of alcohol can have a beneficial effect on patients such as migraineurs, who were reported to have an increased risk of cardiovascular disease.

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Section: Is Alcohol Per Se or Another Component Of Alcoholic Drinks Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alcohol and migraine: trigger factor, consumption, mechanisms. A review

Panconesi¹

2008

J Headache Pain

123

126

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“…This property may be connected (at least in part) to the previously described histamine-releasing factors (HRFs) detected in the plasma of migraine patients. This is indirectly reasserted by the absence of any IgE-dependent histamine release [32] in the investigated patients and by the normal plasma levels of the main HRFs, i.e. IL-3, IL-5, GM-CSF, and MCP1-4 (unpublished results).…”

Section: Discussionmentioning

confidence: 64%

Desialylated transferrin in plasma of patients with migraine without aura

Launay

Tabuteau

Pradalier³

2000

J Headache Pain

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oxidants, CTAP III and NAP2 have already been described [17,18].Transferrin (TF) not only transports iron in all extracellular fluids but also exerts many additional properties, including cell growth stimulation, bacteriostatic action and inhibition of histamine release from mast cells and basophils [19][20][21][22][23]. TF is a 75 kDa glycoprotein containing 679 amino acids and two glycan chains. For each, the last residue is a sialic (N-acetyl neuraminic) acid which can be hydrolyzed by neuraminidase. Circulating TF mainly originates from hepatocytes, its intracellular precursor being asialoapotransferrin. Transferrin receptors, which are present throughout the body, are abundant (10 6 /cell) on the basophil plasma membrane [24]. They are also involved in the development of the nervous system [25].Because of the known relationships between TF and histamine release, we decided to investigate the histamine-releasing ability of this glycoprotein in the plasma of MO patients. Jean-Marie Launay François Tabuteau André PradalierAbstract Patients with migraine without aura (MO), either during or between attacks, present elevated histamine levels in platelet-poor plasma but normal whole blood histamine levels, compared with controls. This finding is usually interpreted as an increased histamine release from basophils due to unidentified histamine-releasing factors. Compared with 10 control plasma samples, each sample from 12 MO patients (5 during and 7 between in attacks) contained normal amounts of iron and immunologically reactive transferrin but decreased transferrin iron-binding capacity. As transferrin inhibits histamine release in vitro, such a functional abnormality, probably due to modifications of the transferrin glycan moiety (desialylated transferrin), may well account for the increased histamine release observed in MO patients. We suggest that glycanmodified transferrin may be related to migraine histamine-releasing factors.

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“…Während Migräneattacken im Speziellen wurden erhöhte Histaminkonzentrationen im Plasma bei 27 Patienten beobachtet [47]. Mehrere Studien berichten über teilweise erhöhte Konzentrationen des unspezifischen, gesamten IgE bei Migränepatienten [3,20,70]. Weitere Studien bei Erwachsenen (mit n=6 [74] bis n= 119 [62] fanden keine erhöhten IgE-Spiegel [62,67,74,86].…”

Section: Allergie Und Migräneunclassified

Immunsystem und primäre Kopfschmerzsyndrome

Empl

Straube²

2001

Der Anaesthesist

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The association between pain and inflammation and certain clinical signs led physicians to suspect a connection between immunological mechanisms and headache syndromes even years ago.This review intends to give an overview of the literature which deals with immunological mechanisms in headache syndromes -with divergent results.Thus, a food allergy as a cause of migraine only seems to be relevant in a few isolated cases.Immunoglobulins or infections do not seem to play a role.Whether the complement system, auto-antibodies, immune cells or cytokines are involved in migraine pathophysiology, still remains to be determined.With regards to cluster headache, a participation of the immune system seems more probable.Although a systemic vasculitis or auto-antibodies probably do not contribute to cluster headache pathophysiology, reports of an immune activation, especially of T-cells, predominate the literature. Nevertheless, the evidence for an immunogenically triggered cluster attack is still lacking.In summary, only a mutual modulation of the immune and the pain system can be assumed with certainty.

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Total IgE, Specific IgE and Prick-Tests Against Foods in Common Migraine—A Prospective Study

Cited by 33 publications

References 15 publications

Alcohol and migraine: trigger factor, consumption, mechanisms. A review

Alcohol and migraine: trigger factor, consumption, mechanisms. A review

Desialylated transferrin in plasma of patients with migraine without aura

Immunsystem und primäre Kopfschmerzsyndrome

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