Total isoflavones from soybean and tempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain

Ahmad, Aliya; Ramasamy, Kalavathy; Jaafar, Siti Murnirah; Majeed, Abu Bakar Abdul; Mani, Vasudevan

doi:10.1016/j.fct.2013.12.025

Cited by 79 publications

(56 citation statements)

References 39 publications

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“…Although many studies described about the positive aspect of SI in improving cognitive functions; [234,235] however, there are still some contradictory studies. [236,237] Ahmad et al [238] compared the neuroprotective effects of SI and tempeh isoflavones (TI) and led to the conclusion that TI were more potent in ameliorating the problem of amnesia and neuroinflammation at high doses by curbing various signaling pathways and enzyme activity. Moreover, an in vitro study showed that genestein content in soy product (tofu) resulted in enhanced accumulation of amyloid beta peptide which culminated to cognitive impairment.…”

Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

Soy Bioactive Components in Functional Perspective: A Review

Garg

Lule

Malik

et al. 2016

International Journal of Food Properties

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Functional foods are the focus of attraction for well-being. The healthy living of Asians may be attributed to a diet enriched with soy isoflavones viz. genistein and daidzein which fills the gap of proteinaceous diet in vegetarians. Several factors, such as administration, dosage, metabolism, ingestion of other pharmacological substances, type of estrogen receptors, and presence or absence of endogenous estrogen, affect the activities and bioavailability of isoflavones. The mode of therapeutic action could be either through the stimulation of estrogen receptors or by the non-involvement of estrogen receptors. Soy, due to its isoflavones content, serves as a balanced and remedial substitute in combating various lifestyle disorders, like cancer prevention, by interruption of the breakdown of extracellular matrix that surrounds growing vessels and tumors, lowering of lipid and blood insulin levels by regulating lipid and glucose metabolism, alleviation of menopausal symptoms, and osteoprotective effects by modulating estrogen receptors, thus acting as a safer switch to hormone replacement therapy, anti-hypertensive effect which may also contribute to cardioprotective, anti-oxidative effect, regulation of cognitive functions, and many others. Therefore, it could be regarded as a valuable therapeutics. However, since soy isoflavones also act as endocrine disruptors, they also possess some negative effects. Concerns have been raised in relation to thyroid function abnormality. In view of the previously mentioned facts an attempt has been made to review the literature available on both beneficial as well as deleterious role of isoflavones, soy derived bioactive compounds.

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Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

Soy Bioactive Components in Functional Perspective: A Review

Garg

Lule

Malik

et al. 2016

International Journal of Food Properties

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“…Research has demonstrated that scopolamine-induced OS increases the levels of malondialdehyde (MDA) [50,63,[67][68][69]. In line with the earlier study by Hritcu et al [70], ex vivo determination of MDA levels in the brains of cognitive-impaired mice demonstrated high MDA profile in the negative control.…”

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confidence: 52%

In VivoCognitive-Enhancing,Ex VivoMalondialdehyde-Lowering Activities and Phytochemical Profiles of Aqueous and Methanolic Stem Bark Extracts ofPiliostigma thonningii(Schum.)

Moriasi

Ireri

Ngugi

2020

International Journal of Alzheimer's Disease

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Cognitive impairment (CI) is among the leading causes of disability in humans. It is estimated that over 35.6 million people are suffering from Alzheimer’s disease- (AD-) associated cognitive deficits globally with these statistics projected to rise over 115.4 million by the year 2050. There is no specific etiology for this cognitive impairment; however, various contributing factors including advancing age (>60 years old), oxidative stress, cerebral injuries, infections, neurologic disorders, and cancer have been implicated. Despite various attempts to manage CI, no curative medicines are yet available. The current drugs used to manage symptoms of AD-associated CI including Donepezil and Rivastigmine among others are only palliative rather than therapeutic. Furthermore, these agents have been associated with undesirable side effects. This calls for alternative and complementary approaches aimed at either preventing or reverting AD-related CI in a curative way without causing adverse events. It is estimated that over 80% of the world’s population utilize herbal medicines for basic healthcare as it is considered safe, affordable, and easily accessible as opposed to conventional healthcare. Various parts of P. thonningii are used in traditional medicine to manage various conditions including CI. However, empirical and scientific data to validate these uses is lacking. In this study, the Morris water maze (MWM) experiment was adopted to evaluate the cognitive-enhancing effects of the studied plant extracts. The malondialdehyde (MDA) profiles in the brains of experimental mice were determined using the thiobarbituric acid reactive substances (TBARS) test. Moreover, qualitative phytochemical profiling of the studied plant extracts was performed using standard procedures. The results showed remarkable cognitive-enhancing activities which were reflected in significantly shorter transfer latencies, navigation distances, longer time spent in platform quadrant, and lower MDA levels compared with those recorded for the negative control mice (p<0.05). Phytochemical screening of the studied plant extracts revealed the presence of antioxidant phytocompounds, which may have played key roles in the extracts’ potency. Based on the findings herein, P. thonningii extracts, especially the aqueous ones have a promising potential for the management of AD-associated CI. Further studies aimed at isolating and characterizing specific active compounds for CI from P. thonningii are recommended. Additionally, specific mode(s) of action of active principles should be elucidated. Moreover, toxicity studies should be done on the studied plant extracts to ascertain their safety.

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“…Dietary supplementation with fruit or vegetable extracts high in antioxidants (e.g. blueberries, strawberries, walnuts, and Concord grape juice) has shown to improve behaviour and decrease the [83,84] 12. Catechins Green tea Rat Improve the spatial cognition learning abilities, antioxidant activity [85] 13.…”

Section: Role Of Phytochemicals In Cognitionmentioning

confidence: 99%

Nutrition, Neuroinflammation and Cognition

Mandalika¹,

Vaidya²

2015

J. Nutr. Ther.

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Activation of microglia and astrocytes leads to the production of cytokines and other inflammatory mediators which may contribute to the apoptotic cell death of neurons observed in many neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Vulnerability of the central nervous system (CNS) to oxidative and inflammatory stress increases with age and has been postulated to be a leading contributing factor to the cognitive impairment and thereby development of neurodegenerative diseases. Suppression of microglial production of neurotoxic mediators may result in neuroprotection. This heightens the interest in the development of neuroinflammation-targeted therapeutics. Nutrition is involved in the pathogenesis of age-related cognitive decline and also neurodegenerative diseases. Certain nutrients facilitate human brain function with their immediate and long term effects. On the other hand, malnutrition influences the brain throughout life, with profound implications on cognitive decline and dementia. Several phytochemicals with potent antioxidant and anti-inflammatory activities, have been shown to repress microglial activation and exert neuroprotective effects. Thus this review highlights the role of foods, nutrients and phytochemicals in suppressing neuro-inflammation and also enhancing cognition.

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Total isoflavones from soybean and tempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain

Cited by 79 publications

References 39 publications

Soy Bioactive Components in Functional Perspective: A Review

Soy Bioactive Components in Functional Perspective: A Review

In VivoCognitive-Enhancing,Ex VivoMalondialdehyde-Lowering Activities and Phytochemical Profiles of Aqueous and Methanolic Stem Bark Extracts ofPiliostigma thonningii(Schum.)

Nutrition, Neuroinflammation and Cognition

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