Total phenolic content, antioxidant activity and pre-clinical safety evaluation of an Anacardium occidentale stem bark Portuguese hypoglycemic traditional herbal preparation

Encarnação, Sofia; Mello-Sampayo, Cristina de; Graça, Nuno A. G.; Catarino, L.; Silva, Isabel Moreira da; Silva‐Lima, Beatriz; Silva, Olga

doi:10.1016/j.indcrop.2015.11.001

Cited by 28 publications

(38 citation statements)

References 36 publications

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“…Tédong et al [ 37 ] reported the hepatotoxicity of A. occidentale L leaves’ hexane extracts, causing vascular congestion, degeneration and necrosis in the dose of 14 g/kg. Nevertheless, the therapeutic doses associated with its biological properties: anti-inflammatory [ 9 ], antibacterial [ 38 , 39 ], anti-tumor [ 40 ], anti-ulcerative [ 41 ] and antioxidant [ 42 ] are considerably lower than those used in that study.…”

Section: Resultsmentioning

confidence: 99%

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Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

et al. 2020

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Section: Resultsmentioning

confidence: 99%

“…Clastogenesis or aneugenesis can occur during the process of erythrocyte maturation, resulting in micronucleus [ 31 ]. These changes can be identified in the analysis of immature (polychromatic) erythrocytes in peripheral blood or bone marrow samples [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

et al. 2020

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“…In addition, Hou et al [ 18 ] and Arumugam et al [ 19 ] also reported that extracts from several plant species in the family Fagaceae were effective in reducing blood glucose of diabetic rats. Recently, Encarnação et al [ 20 ] and Mollica et al [ 21 , 22 , 23 ] reported that Anacardium occidentale stem bark, Capparis spinosa flower buds and Juglans regia leaf are rich in phenolics with high antioxidant activity and at the same time exhibited strong hypoglycemic activity. On the other hand, it is commonly known that alloxan potentially damages the pancreatic β-cells because it led to antioxidant competence of the β-cells being much lower than cells in other tissues did [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic Effects in Alloxan-Induced Diabetic Rats of the Phenolic Extract from Mongolian Oak Cups Enriched in Ellagic Acid, Kaempferol and Their Derivatives

et al. 2018

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Our previous reports showed that crude extract prepared with 50% ethanol (ethanol crude extract, ECE) from Mongolian oak cups possessed excellent in vitro antioxidant capacities as well as inhibitory activities against α-glucosidase, α-amylase and protein glycation caused by its enrichment in phenolics, including mainly ellagic acid, kaempferol and their derivatives. Nevertheless, few in vivo studies on antidiabetic activities of these phenolics were conducted. The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days. In normal rats, no significant differences were exhibited after ECE administration in body weight, fasting blood glucose level, levels of cholesterol, triglyceride, LDL and AST in serum, organ indexes, and levels of GSH and MDA in organs. In diabetic rats, the fasting blood glucose level, indexes of heart and liver, and levels of cholesterol and triglyceride in serum and MDA in heart tissue were significantly decreased. Moreover, HDL levels in serum and SOD activities in the four organs of diabetic rats were significantly improved after ECE administration at 800 mg/kg. Thus, in addition to inhibiting α-glucosidase, α-amylase and protein glycation reported previously, oak cups might contain novel dietary phytonutrients in preventing abnormal changes in blood glucose and lipid profile and attenuating oxidant stress in vivo. The results also implied that it is ellagic acid, kaempferol and their derivatives enriched in ECE that might play vital roles in managing type 1 as well as type 2 diabetes.

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“…For each mouse, 1,000 polychromatic erythrocytes (PCE) were observed and the micronucleus cells were counted within them. In addition, the ratio of PCE and normochromatic erythrocyte (NCE) was counted within 200 of erythrocyte (Encarnação et al, ).…”

Section: Methodsmentioning

confidence: 99%

Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein

Yang

Wang²,

Sun

et al. 2017

J Food Biochem

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This study evaluated the antitumor activity in vitro and biological safety in vivo of Sika deer antler protein (SDAPR). MTT and plate cloning assays were used for anti‐proliferation assessment of prostate cancer cells (PC‐3M) while flow cytometry and western blot were used for apoptosis analysis. In addition, biological safety of SDAPR was evaluated by acute oral toxicity test, bone marrow micronucleus assay and sperm aberration experiment. The results showed that SDAPR could suppress proliferation capacity and induce apoptosis on PC‐3M cells. No adverse effects were observed in Kunming mice following acute oral gavage with SDAPR at a dose of 8 g/kg body weight. The negative results obtained in bone marrow micronucleus test and sperm malformation assay demonstrated that SDAPR had no obvious toxicity to cause mutagenicity. In conclusion, SDAPR exerts anti‐tumor effect with high biological safety, which suggested that it could be used as a potential chemotherapeutic agent for human health. Practical applications It demonstrates that Sika deer antler protein has anticancer effects and high biological safety on prostate cancer cells. In addition, this paper provides scientific basis for treating tumors with Sika deer antler.

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Total phenolic content, antioxidant activity and pre-clinical safety evaluation of an Anacardium occidentale stem bark Portuguese hypoglycemic traditional herbal preparation

Cited by 28 publications

References 36 publications

Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

Hypoglycemic Effects in Alloxan-Induced Diabetic Rats of the Phenolic Extract from Mongolian Oak Cups Enriched in Ellagic Acid, Kaempferol and Their Derivatives

Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein

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