Total serum IgE level in patients of dermatophytosis and its association with various clinical parameters

Patel, Nayankumar Harshadkumar; Padhiyar, Jignaben Krunal; Singh, Ragini; Patel, Tejas

doi:10.25259/ijdvl_1043_19

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Significantly high levels of total serum IgE observed in chronic cases in our study are in line with similar observation by us and other investigators 5 . Levels of IFN‐γ were significantly lower in group B in our study.…”

Section: Discussionsupporting

confidence: 93%

“…3 On the contrary, Th2mediated response via IL-4 and elevated IgE levels are associated with chronicity and recalcitrance of dermatophytosis. 4,5 Another important phenomenon in present epidemic is shift in aetiological agent to Trichophyton mentagrophyte complex. 6 Important factor related to host response in Indian context is exposure to topical steroid (TS) before definitive treatment by dermatologist.…”

Section: Introduction/backg Roundmentioning

confidence: 99%

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Comparative evaluation of host immune response and cytokine signature pertaining to Th1 and Th2 immune arms in serum and tissue among patients of acute localised vs. chronic disseminated dermatophytosis

Patel

Padhiyar

Singh

et al. 2022

Mycoses

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Background India is witnessing an epidemic of dermatophytosis. The role of host immune response against fungi in chronicity and dissemination is topic of ongoing research. We conducted cross‐sectional comparative study to determine the difference in Th1 (IFN‐γ) and Th2 (IL4) response in serum and tissue between acute and localised vs. chronic and disseminated cases. Methods Patients (18–60 years) were divided in two groups—group A (n = 114, BSA <5%, single anatomic site, duration <6 months, n = 118) and group B (n = 107 BSA >10%, > one anatomic site, duration >12 months, n = 118). Clinical parameters along with serum levels of IgE, IL‐4 and IFN‐γ and expression of IL4 and IFN‐γ in dermal infiltrate were compared between group. Results Trichophyton mentagrophytes complex was commonest causative fungi. Serum levels of IgE were significantly higher (median A‐539.2, B‐2901.0, p < .001) whereas levels IL‐4(median A‐21.3, B‐20.4, p < .001) and IFN‐γ(median A‐9.6, B‐5.1, p < .001) were significantly lower in chronic cases. Expression of IL‐4 was observed in most biopsy specimens in both groups without any difference in intensity of staining. Expression of IFN‐γ was not detected in all but one specimen across both the groups. Severe itching (OR:0.050, CI:0.018, 0.139, p < .001), sign of topical steroid abuse (OR:0.203,CI:0.077, 0.537; p = .001), ↓IFN‐γ (OR:4.683, CI:1.634, 13.418; p = .004) correlated significantly and independently with chronic dermatophytosis. Conclusion Our study shows chronic and disseminated cases of dermatophytosis differ immunologically in terms of higher IgE, and lower IL4 and IFN‐γ. Expression of IL4 is present in tissue of both acute, localised and chronic disseminated cases. Expression of IFN‐γ cannot be established in our study.

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Section: Discussionsupporting

confidence: 93%

Section: Introduction/backg Roundmentioning

confidence: 99%

Comparative evaluation of host immune response and cytokine signature pertaining to Th1 and Th2 immune arms in serum and tissue among patients of acute localised vs. chronic disseminated dermatophytosis

Patel

Padhiyar

Singh

et al. 2022

Mycoses

Self Cite

View full text Add to dashboard Cite

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Сучасні Уявлення Про Етіологію Та Патогенез Дерматомікозів

Москалюк,

Кравчук

2023

ІХ

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Представлено узагальнену інформацію про грибкові ураження (дерматомікози) шкіри, її додатків, слизових оболонок порожнини рота та статевих органів. За спектром збудників і глибиною ураження дерматомікози поділяються на кератомікози; дерматоміцети; кандидоз і глибокі мікози. Грибкові захворювання шкіри переважно зумовлені трьома групами збудників: дерматоміцетами, дріжджоподібними грибами та пліснявою. Висвітлено патогенез захворювань, які спричиняють усі зазначені збудники, їх антигени, фактори вірулентності та патогенності, продуковані антибіотикоподібні речовини, а також здатність модулювати імунну відповідь організму хазяїна.

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Total serum IgE level in patients of dermatophytosis and its association with various clinical parameters

Cited by 2 publications

References 9 publications

Comparative evaluation of host immune response and cytokine signature pertaining to Th1 and Th2 immune arms in serum and tissue among patients of acute localised vs. chronic disseminated dermatophytosis

Comparative evaluation of host immune response and cytokine signature pertaining to Th1 and Th2 immune arms in serum and tissue among patients of acute localised vs. chronic disseminated dermatophytosis

Сучасні Уявлення Про Етіологію Та Патогенез Дерматомікозів

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