Total serum IgE levels in systemic lupus erythematosus and associations with childhood onset allergies

Parks, Christine G.; Re, Biagini; Cooper, GS; Gilkeson, GS; Dooley, MA

doi:10.1177/0961203310379870

Cited by 26 publications

(29 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies also indirectly consider this relationship by examining autoimmune disease in relation to allergies and asthma, which showed positive associations [31, 32]. However, some studies report an inverse association of childhood farm exposure to animals and grains with SLE, suggesting the possible operation of hygiene hypothesis [33, 34]. There are some possible explanations for these inconsistent findings.…”

Section: Discussionmentioning

confidence: 99%

“…Previous study considered that examining determinants of IgE levels in SLE patients had limited number of patients and controls [35]; thus, their findings are inconclusive. Total IgE levels in allergic individuals may reflect the potential for antigen-specific IgE production associated with hypersensitivity reactions [33,34]. These studies utilize total serum IgE to test IgE-mediated allergies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Guo

Zhou

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

The influence of co-existing atopy on the prognosis of juvenile systemic lupus erythematosus (JSLE) was assessed in this study. Patients diagnosed with JSLE between October 2005 and April 2016 were enrolled in a prospective study and followed up for 2 years. Management of patients was evaluated using the systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) score and laboratory variables. Eighty JSLE patients were enrolled at diagnosis and divided into those with (n = 35) and without (n = 45) atopy. When compared with the non-atopic group, atopic patients showed higher SLEDAI-2K score at disease onset (16.09 vs. 11.18), higher erythrocyte sedimentation rate (52.89 vs. 38.27 mm/h), higher percentage of total B-cells (25.85 vs. 19.51%), lower percentage (7.26 vs. 9.03%) and cytotoxicity (9.92 vs. 11.32%) of natural killer cells, and lower complement C3 (0.51 vs. 0.69 g/L) (all p<0.05). At 1, 3, 6, 12, 18, and 24 months, JSLE patients with atopy reached higher SLEDAI-2K score and lower ΔSLEDAI-2K improvement rate (at 1 month, 8.34 vs. 4.71 and 43.63 vs. 57.95%, respectively; at 3 months, 8.57 vs. 2.62 and 48.39 vs. 75.10%, respectively; at 6 months, 6.91 vs. 2.38 and 53.59 vs. 77.26%, respectively; at 12 months, 4.71 vs. 1.80 and 69.54 vs. 84.10%, respectively; at 18 months, 4.66 vs. 2.02 and 68.14 vs. 82.93%, respectively; at 24 months, 8.57 vs. 2.62 and 70.00 vs. 81.88%, respectively; all p<0.05). During the 24 months of follow-up, the total number of disease flares was higher in JSLE patients with co-existing atopy (3.77 vs. 1.51, p<0.05), and the atopic group needed much more time to reach the stable condition of the disease (6.88 vs. 4.65 months, p<0.05). JSLE patients combined with co-existing atopy had more severe disease at diagnosis and poorer outcomes than JSLE patients without atopy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Guo

Zhou

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…IgE may play a role in the active phase of SLE [3], but Parks et al assessed total serum IgE levels and atopy in SLE patients and found no evidence of an independent association between the IgE levels and SLE [18]. The immunological hallmark of IgE-mediated allergy is IgE sensitization, which in the vast majority of epidemiological studies has been found to be more common in males than in females [19].…”

Section: Discussionmentioning

confidence: 99%

Atopic Diseases and Systemic Lupus Erythematosus: An Epidemiological Study of the Risks and Correlations

Hsiao

Tsai

Muo

et al. 2014

IJERPH

View full text Add to dashboard Cite

Both atopic diseases and systemic lupus erythematosus (SLE) are immune disorders that may lead to physical complications or multi-system comorbidities. This population-based case-control study was designed to evaluate the risk of SLE associated with atopic diseases. Using a national insurance claims dataset in Taiwan, we identified 1673 patients newly diagnosed with SLE and 6692 randomly selected controls frequency matched for gender, age and index date. The odds ratios (OR) for SLE were calculated for associations with allergic rhinitis, allergic conjunctivitis, atopic dermatitis and asthma. The SLE patients were predominantly female (82.5%) with a mean age of 40.1 (SD = 18.2). The patients with SLE had a higher rate of atopic dermatitis (6.81% vs. 3.06%), and asthma (10.6% vs. 7.64%) was approximately 2 times more common in the patients with lupus than in those without. The patients with atopic disease (atopic dermatitis, allergic rhinitis, allergic conjunctivitis and asthma) were at a significant risk for SLE. The overall risk for SLE increased as the number of atopic diseases increased from 1.46 to 2.29, compared with—individuals without the diseases (p < 0.0001). In conclusion, this population-based case-control study demonstrates a significant relationship between atopic diseases and the risk of SLE, especially for females. Atopic dermatitis plays a stronger role than other types of atopic disease in association with SLE.

show abstract

“…Smoking and drinking were defined as use at least once a week regularly for 1 year. We defined atopy as total IgE ≥100 IU/ml [25,26]. Waist and hip circumference measurements, whole blood sample collection, a lung function test and DNA genotyping were performed.…”

Section: Methodsmentioning

confidence: 99%

The Association between Adult Asthma and Superoxide Dismutase and Catalase Gene Activity

Yang

Huang²,

Huang³

et al. 2011

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Adult asthma is caused by interaction effects of multiple genetic and environmental factors. Some studies have suggested that antioxidant enzyme activity and gene polymorphisms may play important roles in the context of asthma. Therefore, our study objectives were to investigate the association between asthma, antioxidant activities and the polymorphisms of manganese superoxide dismutase (Mn-SOD) or catalase (CAT). Materials and Methods: A case-control study, for which we recruited 250 asthmatic adults and 250 age- and sex-matched controls. All subjects completed a questionnaire. Waist and hip circumference measurements, a lung function test and DNA genotyping were performed. In total, 50 incident cases and 50 matched controls who were non-smokers or had quit smoking for at least 1 year were selected in order to investigate SOD and CAT activity levels. Results: In our study, we did not find a significant association between Mn-SOD Ala16Val, CAT C–262T and asthma. The level of SOD activity in new-onset asthma patients was significantly lower than in control subjects (p < 0.0005). The level of CAT activity in new-onset asthma patients was significantly higher than in control subjects (p < 0.0005). Conclusions: The levels of SOD and CAT activity were significantly related to adult asthma. SOD and CAT activity may be good tools to differentiate potential asthma sufferers. This would enable us to further investigate the mechanism of defective antioxidant enzymes in the context of asthma pathogenesis.

show abstract

Total serum IgE levels in systemic lupus erythematosus and associations with childhood onset allergies

Cited by 26 publications

References 44 publications

Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease

Atopic Diseases and Systemic Lupus Erythematosus: An Epidemiological Study of the Risks and Correlations

The Association between Adult Asthma and Superoxide Dismutase and Catalase Gene Activity

Contact Info

Product

Resources

About