Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161

Kohr, Michael; Papenkordt, Niklas; Jung, Manfred; Kazmaier, Uli

doi:10.1039/d3ob00641g

Org. Biomol. Chem.

2023

DOI: 10.1039/d3ob00641g

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Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161

Michael Kohr

Niklas Papenkordt

Manfred Jung

et al.

Abstract: Matteson homologations and a Pd-catalysed C–H functionalisation are key steps in the synthesis of highly selective HDAC1 inhibitor WF-3161.

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2024

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Cited by 2 publications

References 90 publications

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Total Synthesis of the Naturally Occurring Cyclic Tetrapeptide JM‐47and Analogues through Late‐Stage Functionalization of a Common Scaffold

Ghosh,

Chattopadhyay

2024

Eur J Org Chem

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A unified approach to access the naturally occurring cyclic tetrapeptide JM‐47 and some of its structural variants from a common macrocyclic scaffold has been developed. The key reactions involved a difficult macrocyclization to access the scaffold, and its late‐stage diversification by cross‐metathesis to access the natural product as well as analogues. The synthesis proceeded in good overall yield and high stereochemical integrity. It also confirms the structure and configuration assigned to JM‐47.

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Total Synthesis of the Naturally Occurring Cyclic Tetrapeptide JM‐47and Analogues through Late‐Stage Functionalization of a Common Scaffold

Ghosh,

Chattopadhyay

2024

Eur J Org Chem

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Synthesis and Evaluation of 9-epi-Koshidacin B as Selective Inhibitor of Histone Deacetylase 1

Ghosh,

Biswas,

Bagchi

et al. 2024

J. Nat. Prod.

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Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161

Abstract: Matteson homologations and a Pd-catalysed C–H functionalisation are key steps in the synthesis of highly selective HDAC1 inhibitor WF-3161.

Cited by 2 publications

References 90 publications

Total Synthesis of the Naturally Occurring Cyclic Tetrapeptide JM‐47and Analogues through Late‐Stage Functionalization of a Common Scaffold

Total Synthesis of the Naturally Occurring Cyclic Tetrapeptide JM‐47and Analogues through Late‐Stage Functionalization of a Common Scaffold

Synthesis and Evaluation of 9-epi-Koshidacin B as Selective Inhibitor of Histone Deacetylase 1

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