Total Synthesis with Gram-Scale Radical Process: An Inspiration for Pharmaceutical Industry

Abstract

Radical reactions have emerged as indispensable tools in the synthesis of complex molecules. In this perspective, we will discuss selected total syntheses that make use of radical processes in a scale of at least one gram as the essential transformation, to showcase their potential applicability in the industry related to pharmaceuticals and fine chemicals. The discussion is divided into three main sections: metal-catalyzed hydrogen atom transfer (HAT) cyclization, nonmetal-mediated radical cyclization, and metalcatalyzed reductive cross-coupling reactions. Finally, a summary and outlook of this area are highlighted.