Total thiol redox status as a potent biomarker of PAH-mediated effects on mussels

Grintzalis, Konstantinos; Georgiou, Christos D.; Dailianis, Stefanos

doi:10.1016/j.marenvres.2012.08.004

Cited by 34 publications

(19 citation statements)

References 65 publications

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“…Bocquené and Galgani 1990;Tsangaris et al 2010) because it has long been considered as a specific biomarker for organophosphate and carbamate insecticides (Galgani and Bocquené 1989;Escartín and Porte 1997), However, recent studies have shown that other types of pollutants, such as heavy metals, surfactants, PAHs and microplastics, may also unselectively inhibit AChE activity (Guilhermino et al 1998;Akcha et al 2000;Regoli and Principato 1995;Grintzalis et al 2012;Oliveira et al 2013). Therefore, we have investigated the effect of BDE-47 on AChE in order to test whether it is also affected by this chemical.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels

et al. 2014

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Mussels, Mytilus galloprovincialis, showed a high bioaccumulation ability when exposed to waterborne tetrabromodiphenyl ether (BDE-47), with a bioconcentration factor of 10,900 L Kg(-1) wet weight, and slow depuration rates in clean seawater. Kinetic and concentration-response experiments were performed measuring in the exposed mussel the activities of three molecular biomarkers: glutathione S-transferase (GST), glutathione peroxidase (GPx) and acetylcholinesterase (AChE). The long term (30 days) exposure of mussels to all concentrations (2-15 µg L(-1)) of BDE-47 significantly inhibited the AChE and GST activities, a result that supports the suitability of these biomarkers in marine pollution monitoring programs. However, GPx activity showed a less consistent pattern of response depending on the concentration and the duration of exposure.

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Section: Introductionmentioning

confidence: 99%

Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels

et al. 2014

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“…The key role of GSH alerts for the consequences that the low GSH/GSSG balance revealed under PPCPs exposures may pose to the bivalves when facing stronger salinity gradients or other challenging conditions. Other studies with bivalves also support the use of the GSH/GSSG ratio in the assessment of impacts caused by pollutants (Almeida et al, 2015;Coppola et al, 2017;De Marchi et al, 2018b;Grintzalis et al, 2012;Xia et al, 2016).…”

Section: Accepted Manuscriptmentioning

confidence: 82%

Does salinity modulates the response of Mytilus galloprovincialis exposed to triclosan and diclofenac?

Freitas

Coppola

Costa

et al. 2019

Environmental Pollution

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In the present study Mytilus galloprovincialis mussels were exposed for days to three salinities: 30 (control), 25 and 35. Simultaneously, organisms at each salinity were exposed to either the antimicrobial agent Triclosan (TCS) or the pharmaceutical drug Diclofenac (DIC) at 1 µg/L. Salinity alone and exposure to PPCPs exposures changed mussel's metabolic capacity and oxidative status, but no additive or synergetic effects resulting from the combined exposure to different stressors were observed. Overall the metabolic capacity of mussels was decreased when exposed to TCS and DIC under control salinity, which was less pronounced at salinities out of the control level. TCS had a notorious effect over glutathione peroxidase activity while DIC exposure enhanced catalase response. Such defence mechanisms were able to prevent cellular damage but still a clear reduction in GSH/GSSG ratio after PPCPs exposures indicates oxidative stress which could compromise bivalve's performance to further stressing events.

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“…Contaminant-induced ROS overproduction directs a strong antioxidant response to prevent oxidative stress (Regoli and Giuliani 2014). A rapid (during 1-7 days) activation of the ADS as a response to oil exposure and PAH contamination has been previously described in mussels (e.g., Grintzalis et al 2012;Livingstone 2001;Luna-Acosta et al 2011;Orbea and Cajaraville 2006), and also in gammarids (Hatlen et al 2009;Turja et al 2014b).…”

Section: Mytilus Trossulusmentioning

confidence: 88%

“…In bivalves, the potential of PHE, PYR, and FLU to induce biological responses has been extensively reported (e.g., Grintzalis et al 2012;Moore et al 2007;Okay et al 2006;Richardson et al 2008;Yakan et al 2013). In the present study, among the accumulated individual PAH compounds, the highest tissue concentrations were detected for methylphenanthrene, triphenyl+chrysene, PHE, PYR, and FLU.…”

Section: Mytilus Trossulusmentioning

confidence: 99%

Biomarker responses and accumulation of polycyclic aromatic hydrocarbons in Mytilus trossulus and Gammarus oceanicus during exposure to crude oil

Turja

Sanni

Stankevičiūtė

et al. 2020

Environ Sci Pollut Res

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In the brackish water Baltic Sea, oil pollution is an ever-present and significant environmental threat mainly due to the continuously increasing volume of oil transport in the area. In this study, effects of exposure to crude oil on two common Baltic Sea species, the mussel Mytilus trossulus and the amphipod Gammarus oceanicus, were investigated. The species were exposed for various time periods (M. trossulus 4, 7, and 14 days, G. oceanicus 4 and 11 days) to three oil concentrations (0.003, 0.04, and 0.30 mg L −1 based on water measurements, nominally aimed at 0.015, 0.120, and 0.750 mg L −1 ) obtained by mechanical dispersion (oil droplets). Biological effects of oil exposure were examined using a battery of biomarkers consisting of enzymes of the antioxidant defense system (ADS), lipid peroxidation, phase II detoxification (glutathione S-transferase), neurotoxicity (acetylcholinesterase inhibition), and geno-and cytotoxicity (micronuclei and other nuclear deformities). In mussels, the results on biomarker responses were examined in connection with data on the tissue accumulation of polycyclic aromatic hydrocarbons (PAH). In M. trossulus, during the first 4 days of exposure the accumulation of all PAHs in the two highest exposure concentrations was high and was thereafter reduced significantly. Significant increase in ADS responses was observed in M. trossulus at 4 and 7 days of exposure. At day 14, significantly elevated levels of geno-and cytotoxicity were detected in mussels. In G. oceanicus, the ADS responses followed a similar pattern to those recorded in M. trossulus at day 4; however, in G. oceanicus, the elevated ADS response was still maintained at day 11. Conclusively, the results obtained show marked biomarker responses in both study species under conceivable, environmentally realistic oil-in-seawater concentrations during an oil spill, and in mussels, they are related to the observed tissue accumulation of oil-derived compounds.

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Total thiol redox status as a potent biomarker of PAH-mediated effects on mussels

Cited by 34 publications

References 65 publications

Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels

Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels

Does salinity modulates the response of Mytilus galloprovincialis exposed to triclosan and diclofenac?

Biomarker responses and accumulation of polycyclic aromatic hydrocarbons in Mytilus trossulus and Gammarus oceanicus during exposure to crude oil

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